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Adenine reactions

G. Dryhurst and P.J. Elving, Electrochemical oxidation of adenine reaction products and mechanisms, J. Electrochem. Soc., 5 (1968) 1014-1022. [Pg.433]

Section 15 11 Oxidation of alcohols to aldehydes and ketones is a common biological reaction Most require a coenzyme such as the oxidized form of nicotin amide adenine dmucleotide (NAD" )... [Pg.655]

Figure 11.39 summarizes the reactions taking place in this amperometric sensor. FAD is the oxidized form of flavin adenine nucleotide (the active site of the enzyme glucose oxidase), and FAD1T2 is the active site s reduced form. Note that O2 serves as a mediator, carrying electrons to the electrode. Other mediators, such as Fe(CN)6 , can be used in place of O2. [Pg.520]

Coenzymes such as adenosine diphosphate (ADP), adenosine SGtriphosphate (ATP), nicotinamide adenine dinucleotide (NAD), and nicotinamide adenine dinucleotide, reduced (NADH), are involved in some reactions (4). [Pg.392]

Himethylformamide [68-12-2] can be produced from the reaction of hydrogen cyanide and methanol. Adenine [73-24-5] can be prepared from hydrogen cyanide in Hquid ammonia. Thioformamide [115-08-2] can be produced from hydrogen cyanide and hydrogen sulfide. [Pg.376]

Adenine, 9- -D-2-deoxyribofuranosyl-, 5, 536 Adenine, 8-(2-deoxy-/3-D-ribosyl)-synthesis, 5, 585 Adenine, 2,8-dialkyl-synthesis, 5, 569 Adenine, 2,8-dichloro-reactions... [Pg.512]

Nicotinamide, (S)-N-(a-methylbenzyl)-hydrogen bonding, 2, 111 Nicotinamide, N-phenyl-hydrogen bonding, 2, 111 Nicotinamide adenine dinucleotide in biochemical pathways, 1, 248 coenzyme system with NADH, 2, 121 reactions, 2, 382 reduction, 2, 281, 283... [Pg.710]

Oxidation of P-nicotinamide adenine dinucleotide (NADH) to NAD+ has attracted much interest from the viewpoint of its role in biosensors reactions. It has been reported that several quinone derivatives and polymerized redox dyes, such as phenoxazine and phenothiazine derivatives, possess catalytic activities for the oxidation of NADH and have been used for dehydrogenase biosensors development [1, 2]. Flavins (contain in chemical structure isoalloxazine ring) are the prosthetic groups responsible for NAD+/NADH conversion in the active sites of some dehydrogenase enzymes. Upon the electropolymerization of flavin derivatives, the effective catalysts of NAD+/NADH regeneration, which mimic the NADH-dehydrogenase activity, would be synthesized [3]. [Pg.363]

Cleavage at A or G If the DNA is first treated with acid, dimethyl sulfate methylates adenine at the 3-position as well as guanine at the 7-position (not shown). Subsequent reaction with OH and piperidine triggers degradation and displacement of the methylated A or G purine base and strand scission, essentially as indicated here for reaction of dimethyl sulfate with guanine. [Pg.360]

The overall direction of the reaction will be determined by the relative concentrations of ATP, ADP, Cr, and CrP and the equilibrium constant for the reaction. The enzyme can be considered to have two sites for substrate (or product) binding an adenine nucleotide site, where ATP or ADP binds, and a creatine site, where Cr or CrP is bound. In such a mechanism, ATP and ADP compete for binding at their unique site, while Cr and CrP compete at the specific Cr-, CrP-binding site. Note that no modified enzyme form (E ), such as an E-PO4 intermediate, appears here. The reaction is characterized by rapid and reversible binary ES complex formation, followed by addition of the remaining substrate, and the rate-determining reaction taking place within the ternary complex. [Pg.451]

Nicotinamide adenine dinucleotide (NAD )-dependent dehydrogenases are enzymes that typically behave according to the kinetic pattern just described. A general reaction of these dehydrogenases is... [Pg.452]

Several classes of vitamins are related to, or are precursors of, coenzymes that contain adenine nucleotides as part of their structure. These coenzymes include the flavin dinucleotides, the pyridine dinucleotides, and coenzyme A. The adenine nucleotide portion of these coenzymes does not participate actively in the reactions of these coenzymes rather, it enables the proper enzymes to recognize the coenzyme. Specifically, the adenine nucleotide greatly increases both the affinity and the speeifieity of the coenzyme for its site on the enzyme, owing to its numerous sites for hydrogen bonding, and also the hydrophobic and ionic bonding possibilities it brings to the coenzyme structure. [Pg.588]

Nicotinamide is an essential part of two important coenzymes nicotinamide adenine dinucleotide (NAD ) and nicotinamide adenine dinucleotide phosphate (NADP ) (Figure 18.19). The reduced forms of these coenzymes are NADH and NADPH. The nieotinamide eoenzymes (also known as pyridine nucleotides) are electron carriers. They play vital roles in a variety of enzyme-catalyzed oxidation-reduction reactions. (NAD is an electron acceptor in oxidative (catabolic) pathways and NADPH is an electron donor in reductive (biosynthetic) pathways.) These reactions involve direct transfer of hydride anion either to NAD(P) or from NAD(P)H. The enzymes that facilitate such... [Pg.588]

In this case, the tertiary and electron-deficient MPM group is retained. " A very slow cleavage of an MPM protected adenosine was attributed to its reduced electron density as a result of n stacking with the adenine. Typically, these reactions are complete in < 1 h, but in this case complete cleavage required 41 h. [Pg.88]

The utility of the Zincke reaction has been extended to the preparation of various NAD and NADH analogs. Holy and co-workers synthesized a series of NAD analogs containing nucleotide bases as a means to study through-space interaction between the pyridinium and base portions. Nicotinamide-derived Zincke salt 8 was used to link with various adenine derivatives via tethers that contained hydroxyl (105 —> 106, Scheme 8.4.35), phosphonate (107—>108, Scheme 8.4.36), and carboxylate "... [Pg.370]


See other pages where Adenine reactions is mentioned: [Pg.418]    [Pg.1293]    [Pg.418]    [Pg.1293]    [Pg.176]    [Pg.274]    [Pg.274]    [Pg.646]    [Pg.1175]    [Pg.539]    [Pg.210]    [Pg.211]    [Pg.28]    [Pg.40]    [Pg.44]    [Pg.45]    [Pg.26]    [Pg.26]    [Pg.44]    [Pg.121]    [Pg.122]    [Pg.393]    [Pg.106]    [Pg.646]    [Pg.1175]    [Pg.591]    [Pg.125]    [Pg.20]    [Pg.270]    [Pg.63]   
See also in sourсe #XX -- [ Pg.58 ]

See also in sourсe #XX -- [ Pg.47 ]

See also in sourсe #XX -- [ Pg.24 , Pg.25 , Pg.32 , Pg.33 , Pg.40 , Pg.42 ]

See also in sourсe #XX -- [ Pg.47 ]




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3-Deaza-adenine, reaction with

Adenine electrochemical reaction

Adenine phosphoribosyltransferase, reaction catalyzed

Adenine reaction with

Adenine, 9- displacement reactions

Flavin adenine dinucleotide , reactions

Flavin adenine dinucleotide electrochemical reaction

Flavin adenine dinucleotide reactions involving

Flavin adenine dinucleotide redox reactions

Nicotinamide adenine dinucleotide cellular reaction

Nicotinamide adenine dinucleotide reaction mechanism

Nicotinamide adenine dinucleotide reactions

Nicotine adenine dinucleotide, reaction with

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