Triggered degradation

Cleavage at A or G If the DNA is first treated with acid, dimethyl sulfate methylates adenine at the 3-position as well as guanine at the 7-position (not shown). Subsequent reaction with OH and piperidine triggers degradation and displacement of the methylated A or G purine base and strand scission, essentially as indicated here for reaction of dimethyl sulfate with guanine. 

Which degradation initiators are present in the application that may trigger degradation at the desired time ... 

It is generally accepted that Ca + mobilization is crucial for the activation of phospholipases. However, Sevanian and coworkers (Sevanian et al., 1981 Sevanian and Kim, 1985) demonstrated that phospholipase A2 can also be activated in the absence of elevated Ca + by the presence of peroxi-dized fatty acids in phospholipids. The degree of phospholipase activation was correlated with the extent of TBARS. Thus, both peroxidized fatty acids and Ca + can independently trigger degradation of membrane lipids, but may also act syner-... 

Figure 8.3 (a) Schematic illustration of the NIR-triggered degradation of a photo-... 

The plastic temperature rise resulting from internal friction in the distributor channels and nozzle does not normally exceed 5 °C for LDPE, HOPE, PP, PS or polyurethane (PU), but it can easily exceed 15 °C for PVC, PMMA or POM of high viscosity, which is enough to trigger degradation of the plastic. 

Wong, A. D., Dewit, M. A. and Gillies, E. R. (2012). Amplified release through the stimulus triggered degradation of self-immolative oligomers, dendrimers, and linear polymers. Advanced Drug Delivery Reviews, 64,1031-1045. 

Dual-responsive polymer-based drug delivery vehicles offer even more versatility. Both temperature and enzyme-responsive micelles were formed from block polymers. While the thermoresponsive properties of the material allow it to be injected and subsequently form a reservoir in the body from where micelles enter the blood stream, the enzyme-responsive component allows triggered degradation of the micelles and release of the drug at the location of the diseased tissue (Garripelli et fl/.,2011). A doubly enzyme-responsive system can be obtained, for example, by designing polymer capsules with a shell that contains two layers. The two layers are degraded by different enzymes thus, proteins entrapped in the outer layer itself can be released upon exposure to the first enzyme, whereas the second enzyme destroys the capsule completely and liberates the proteins entrapped in the cavity of the vehicle (Itoh et al, 2008). 

Evaluating residual safety tkne Evaluating available fiaictlona Trigger degradation manager... 

Kostiainen, M.A., RosUo, H. Low-molecular-weight dendrons for DNA binding and release by reduction-triggered degradation of multivalent interactions. Chem. Eur. J. 15, 5656-5660... 

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