Acute promyelocytic leukemia, differentiation

Ueda K, Nagai S, Miyashita SI, Kaise T, Ichikawa M, Kumano K, Hangaishi A, Nannya Y, Kurokawa M. Arsenic-induced pericardial and pleural effusion without acute promyelocytic leukemia differentiation syndrome. Leuk Res 2010 34(1) e25-6. [Pg.361]

Granulocyte differentiation acute promyelocytic leukemia PBMCs (in vivo) Cultured bone marrow mononuclear cells (in vitro) All-trans retinoic acid (ATRA) Promoter analysis of ATRA response genes suggest molecular mechanism underlying ATRA-induced granulocytic differentiation [30]... [Pg.420]

Mechanism of Action A retinoid that decreases cohesiveness of follicular epithelial cells. Increases turnover of follicular epithelial cells. Bacterial skin counts are not altered. Transdermal Exerts its effects on growth and differentiation of epithelial cells. Antineoplastic Induces maturation, decreases proliferation of acute promyelocytic leukemia (APL) cells. Therapeutic Effect Causes expulsion of blackheads alleviates fine wrinkles, hyperpigmentation causes repopulation of bone marrow and blood by normal hematopoietic cells. [Pg.1258]

Bastie JN, Balitrand N, Guillemot I, et al. Cooperative action of 1 alpha,25-dihydroxyvitamin D3 and retinoic acid in NB4 acute promyelocytic leukemia cell differentiation is transcriptionally controlled. Exp Cell Res. 2005 310 319-330. [Pg.587]

As an alternative to using synthetic analogs for disease treatment, the natural ligand for the retinoic acid receptor, all-irans-retinoic acid (ATRA), is used effectively in the treatment of acute promyelocytic leukemia (APL) (73). Chromosomal translocations in APL patients are responsible for the cellular transformation in this disease. The transformation results in a fusion of the retinoic acid receptor alpha (RARa) with another protein (73). Treatment of APL patients with pharmacologic doses of ATRA induces complete remission by restoring normal granulocytic differentiation (74, 75). [Pg.1856]

By comparison, acute promyelocytic leukemia is characterized by translocations involving the RARA gene (Table 39 3). These translocations result in a block of myeloid differentiation at the promyelocytic stage. It has been shown that the maturational arrest is due in part to the recruitment of the nuclear co-repressor/histone deacetylase complex. The ability of all trans retinoic acid (ATRA) to bind to PML/RARa, resulting in the release of the nuclear co-repressor complex, partly explains the ability of ATRA to relieve the maturational block in promyelocytes that is central to the development of acute promyelocytic leukemia. [Pg.1467]

P. Fenaux and L. Degos Differentiation therapy for acute promyelocytic leukemia. New England Journal of Medicine 337, 1076 (1997). [Pg.928]

Arsenic is an organic element and a well-known poison that is an effective treatment for acute promyelocytic leukemia (see Table 124—15). As an antineoplastic, arsenic trioxide acts as a differentiating agent, inducing the growth progression of cancerous cells into mature, more normal cells. It also induces programmed cell death or apoptosis. [Pg.2309]

Iriyama N, Yuan B, Hatta Y, Horikoshi A, Yoshino Y, Toyoda H, Aizawa S, Takeuchi J. Granulocyte colony-stimulating factor potentiates differentiation induction by all-trans retinoic acid and arsenic trioxide and enhances arsenic uptake in the acute promyelocytic leukemia cell line HT93A. Oncol Rep. 2012 28 1875-82. [Pg.710]

Vitamin A (retinol) (Fig. 7.12) and its metabolic oxidation products assume a critical physiological role in growth, development and differentiation of epithelial tissue, the maintenance of vision, and as well in spermatogenesis and the normal development of the placenta and the foetus. (allE)-Retinoic acid and (13Z)-retinoic acid are important medicaments for the treatment of acne and psoriasis the former has also demonstrated complete remission in most cases of acute promyelocytic leukemia (APL). [Pg.595]

NAKAI, induces the differentiation of human acute promyelocytic leukemia HL-60 cells. Biol Pharm Bull 25 1446... [Pg.3545]

Castaigne, S., Chomienne, C, Daniel, M, T, Ballerim, P, Berger, R Fenaux, P, and Degos, L. (1990) All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia I Clinical results. Blood 76, 1704-1709... [Pg.243]

Grignani, F, Ferrucci, P F, Testa, U., Talamo, G, Fagioli, M., Alcalay, M, Mencarelli, A, Peschle, C, Nicoletti, I, and Pelicci, P G. (1993) The acute promyelocytic leukemia-specific PML-RARa fusion protein inhibits differentiation and promotes survival of myeloid precursor cells Cell 74,423-431... [Pg.352]

Elliott, S., Taylor, K., White, S., Rodwell, R., Marlton, P, Meagher, D, Wiley, J, Taylor, D., Wright, S, and Timms, P (1992) Proof of differentiative mode of action of all-trans retinoic acid in acute promyelocytic leukemia using X-linked clonal analysis B/oouf 79,1916-1919... [Pg.352]

Gianni M, Zanotta S, Terao M, Rambaldi A, Garattini E (1996) Interferons induce normal and aberrant retinoic-acid receptors type a in acute promyelocytic leukemia cells potentiation of the induction of retinoid-dependent differentiation markers. Int J Cancer 68 75-83... [Pg.230]

Castaigne S, Chomienne C, Daniel MT, Berger R, Fenaux P, Degos L (1990) AVi-trans retinoic acid as a differentiating therapy for acute promyelocytic leukemias. I. Clinical results. Blood 76 1704-1709... [Pg.239]

Warrel RP, Frankel SR, Miller WH, Scheinberg DA, Itri IM, Hittelman WN, Vyas R, Andreeff M, Tafiiri A, Jakubowski A et al (1991) Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-tram retinoic acid). New EnglJ Med 324 1385-1395... [Pg.239]

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