Active methyl

The salts (29) condense with quartenary salts of heterocycHc bases containing an activated methyl group to yield the polycarbocyanines (30), where = 4 or 5 (73). Higher vinylogous dyes (30), hexa- and heptacarbocyanines (n = 6 or 7), have been synthesized by analogous methods (106). 

Nitriles. Nitriles can be prepared by a number of methods, including ( /) the reaction of alkyl haHdes with alkaH metal cyanides, (2) addition of hydrogen cyanide to a carbon—carbon, carbon—oxygen, or carbon—nitrogen multiple bond, (2) reaction of hydrogen cyanide with a carboxyHc acid over a dehydration catalyst, and (4) ammoxidation of hydrocarbons containing an activated methyl group. For reviews on the preparation of nitriles see references 14 and 15. 

Reactivity of Five-membered Rings with Two or More Heteroatoms (ii) Activated methyl and methylene carbanions... 

Procedure has been proposed for the P(V) and As(V) determination based on the selective extraction of ionic associate of Crystal Violet with reduced molybdophosphate with mixture of inert (toluene) and active (methyl isobutyl ketone) solvents. Extraction of reagent is negligible. After concentration determination lower than 10 mol/1 of P(V) and As(V) is possible. 

MANNICH - ESCHENMOSER Methylenation reagent Ammomethylation of activated methyl or methylene groups by in situ formed MeaN -CHR (Mannich) Me2N- -=CH2 X reagent for o methylenation (Eschenmoser)... 

E. Condensation Involving Activated Methyl Groups of Methyl-... 

The required nitrite esters 1 can easily be obtained by reaction of an appropriate alcohol with nitrosyl chloride (NOCl). The 3-nitroso alcohols 2 formed by the Barton reaction are useful intermediates for further synthetic transformations, and might for example be converted into carbonyl compounds or amines. The most important application for the Barton reaction is its use for the transformation of a non-activated C-H group into a functional group. This has for example been applied for the functionalisation of the non-activated methyl groups C-18 and C-19 in the synthesis of certain steroids. ... 

Coupling Components Containing Activated Methyl, Methylene, and Methine Groups 332... 

Coupling Components Containing Activated Methyl Groups etc. 

Other methylketones and differently activated methyl compounds can also be used to synthesize formazanes in the same manner, as was shown, for example, in early work by Wahl and Lebris (1954) on the coupling with 2-methylbenzothiazole (Scheme 12-39). 

Reaction of benzylideneaniline with optically active methyl p-tolyl sulphoxide 449 in the presence of lithium diethylamide produces the corresponding jS-anilinosulphoxide 450 with 100% asymmetric induction. Its reductive desulphurization with Raney nickel leads to the enantiomerically pure amine 451524 (equation 270). When the same optically active... 

Demailly and coworkers195 found that the asymmetric induction increased markedly when optically active methyl pyridyl sulfoxide was treated with an aldehyde. They also synthesized (S)-chroman-2-carboxylaldehyde 152, which is the cyclic ring part of a-tocopherol, by aldol-type condensation of the optically active lithium salt of a,/3-unsaturated sulfoxide. Although the diastereomeric ratio of allylic alcohol 151 formed from lithium salt 149 and 150 was not determined, the reaction of 149 with salicylaldehyde gave the diastereomeric alcohol in a ratio of 28 72196. 

The reduction of tributyltin methoxide with optically active methyl-phenyl-1-naphthylsilane involves retention of configuration at the silicon atom and follows second-order kinetics (2 72). The reaction between tributyltin methoxide and ring-substituted dimethylphenylsilanes shows a Hammett p-value of -t-0.903, and that between dimethyl-phenylsilane and ring-substituted tributyltin phenoxides shows a p-value of -1.319 this is compatible with the reactions proceeding through a 4-centered (SNi-Si) transition state (272, 173). 

The Environmental Protection Agency (EPA) identifies the most serious hazardous waste sites in the nation. These sites make up the National Priorities List (NPL) and are the sites targeted for long-term federal cleanup activities. Methyl parathion has been found in at least 16 of the 1,585 current or former NPL sites. However, the total number of NPL sites evaluated for this substance is not known. As more sites are evaluated, the sites at which methyl parathion is found may increase. This information is important because exposure to this substance may harm you and because these sites may be sources of exposure. 

As noted earlier, diverse forms of organomercury are released into the environment as a consequence of human activity. Methyl mercury presents a particular case. As a product of the chemical industry, it may be released directly into the environment, or it may be synthesized in the environment from inorganic mercury which, in turn, is released into the environment as a consequence of both natural processes (e.g., weathering of minerals) and human activity (mining, factory effluents, etc.). 

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