Methyl 2-deoxy-2- biological activity

Folic acid, 4-amino-4-deoxy-3, 5 -dichloro-10-methyl- biological activity, 3, 326... 

Folic acid, 4-amino-4-deoxy-10-methyl-, 1, 164 3, 325 as anticancer drug, 1, 263 biological activity, 3, 325 Folic acid, 4-amino-10-methyl-toxicity, 1, 141 Folic acid, 7,8-dihydro-biosynthesis, 3, 320 synthesis, 1, 161, 3, 307 Folic acid, 4-dimethylamino-hydrolysis, 3, 294 Folic acid, 5-formiminotetrahydro-biological activity, 3, 325 Folic acid, 5-formyl-5,6,7,8-tetrahydro-biological activity, 3, 325 chirality, 3, 281 occurrence, 3, 325 Folic acid, 10-forfnyltetrahydro-biological activity, 3, 325 Folic acid, 5,10-methenyl-5,6,7,8-tetrahydro-biological activity, 3, 325 chirality, 3, 281 Folic acid, 5-methyl-chirality, 3, 281 Folic acid, 9-methyl-toxicity, 1, 141... 

It should be noted that the various 15-deoxy-16-hydroxy-prostaglandins prepared in the course of our studies consisted of two racemates ( 1 1 by NMR) epimeric at Cje which were not separable by TLC or HPLC. However, introduction of an allylic double bond (A or 16-vinyl) frequently made separation feasible. A 17-methyl group (4 racemates) also allowed separation into two components. Of necessity, the compounds were tested as the racemic mixture, although it is likely that biological activity largely resides with only one of the four diastereomers (40.56). 

The fluoro analogs, however, had somewhat reduced biological activities. On the other hand, 4"-epi-hydroxy, oxo, cyano, even deoxy, and particularly methyl analogs have good activities in die twospotted spider mite and southern armyworm assays. One also often observes with a minor modification a shift in spectrum, as seen with the southern army worm activities of the two epimeric 4"-methyl derivatives (EC q = 0.5 and 8.0 ppm, respectively). 

Methods for synthesizing anisomycin and pentenomycin, ° and the chemistry and biological transformations of bleomycin and phleomycin have been reviewed.D-Ribo-furanosyl and -pyranosyl derivatives of iV-methyl-iV-nitroso-urea have been prepared as analogues of streptozotocin [2-deoxy-2-(JV-methyl-A -nitrosoureido)-D-glucose] they were reported to be more active against LI 210 leukaemia in mice and less toxic than the parent antibiotic. Likewise N- 2-chloroethyl)-iV-nitrosoureido derivatives of cyclopentane tetrols (35) and cyclohexane tetrols (36) have been synthesized for comparison with streptozotocin. ... 

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