Acetyl methionine

Figure 4.7 Classical kinetic resolution synthesis of L-methionine from IV-acetyl-methionine applying an ultrafiltration-membrane reactor and crystallization step as well as racemization step...

Acetyl methionine Ammonia sodium Flydrogen chloride... 

The mechanism of N-acetylation of a-crystallin is quite interesting. The N-terminal residue has been identified as N-acetyl methionine. This methionine residue is derived from Met-tRNA et which is responsible for the initiation of the polypeptide chain and not Met-tRNAmet which incorporates the methionine residue in the growing polypeptide chain. It is clear that the N-acetylation is a true posttranslational process since acetyl Met-tRNA cannot replace formyl Met-tRNA et. Moreover, N-acetylation occurs when the polypeptide chain has reached a length consisting of approximately 25 amino acid residues. Other proteins, such as ovalbumin, are also acetylated during the early stages of polymerization on the polysome, and the protein acetyltransferase activity must therefore be associated with the protein-synthesizing apparatus. 

The effect of N-acetyl substitution in methionine on the nature of transients formed after one-electron oxidation was studied as a function of pH and NAM concentration. The observed absorption bands with X = 290 nm, 360 nm, and 490 nm were respectively assigned to a-(alkylthio)alkyl, hydroxysulfuranyl and dimeric radical cations with intermolecular three-electron bond between sulfur atoms. N-acetylmethionine amide (NAMA) (Chart 7) represents a simple chemical model for the methionine residue incorporated in a peptide. Pulse radiolysis studies coupled to time-resolved UV-Vis spectroscopy and conductivity detection of N-acetyl methionine amide delivered the first experimental evidence that a sulfur radical cation can associate with the oxygen of an amide function vide infra). ... 

Mishra B, Priyadarsini KI, Mohan H. (2005) Pulse radiolysis studies on reaction of OH radical with N-acetyl methionine in aqueous solution. Res Chem Intermed 31 625-632. 

The amino acid sequence of a and /3 subunits of tropomyosin from rabbit skeletal muscle has been determined (Stone and Smillie, 1978 Sodek et al, 1978 Mak et al, 1980). Both subunits consist of a single peptide of 284 amino acid residues. The N-terminal residue is acetylated methionine, and the C-terminal residues is He. Assuming that all resi-... 

The gene encoding ai-PI has been cloned and the recombinant protein expressed in both yeast and in E. coli [58,59]. Recombinant ai-PI differs from native ai-PI in that it lacks the carbohydrate side chains and contains N-acetyl-methionine at its N-terminus [60]. Its molecular weight is approximately 42,000 daltons. Since the inhibitory properties of the recombinant ai-PI against elastase are similar to the wild-type molecule, production of recombinant protein in yeast provides an abundant source of the inhibitor. 

The hydrolysis reaction of N-acetyl amino acids is equilibrium-limited, however, the equilibrium is well on the side of the hydrolysis so that at low substrate concentrations conversion is almost quantitative. For the case of N-acetyl methionine, Wandrey and Flaschel determined the equilibrium constant K defined as in Eq. (1)... 

Keywords Alpha-amylase complex. Amino acid acylase. Acetyl methionine. Metal ions and Ninhydrin. 

In an attempt to find a suitable source of amino acid acylase, Sanzyme, essentially an alpha-amylase complex extracted from a strain of Aspergillus oryzae was explored for the presence of this enzyme. Aspergillus oryzae is known to contain amylase, however, there is no report available for the presence of this enzyme in Sanzyme strain. It was found out that the crude Sanzyme samples contain 7.8 units of amino acylase activity [2], where one unit is defined as 1 micro mole of acetyl methionine hydrolysed/hr/mg of enzyme. It was also found out that the purified form of amino acylase from Sanzyme contain 28.4 units of activity [3] which is high when compared to any other amino acylase reported in literature. 

From Fig-1 the activity of purified amino acid acylase from Sanzyme is calculated as 28.4 units where 1 unit is defined as 1 micro mole of acetyl methionine hydrolysed/hr/mg of enzyme. This activity of native enzyme is taken as 100% and it is compared with the activity of enzyme in presence of metal ions. From Fig-1 and Table-1 it can be observed that the activity of amino acylase in presence of Co" ions is increased by 48% when compared to native enzyme. In presence of Ni" and Ca ions the activity of enzyme is reduced by 20%... 

In addition to the sulfur-containing amino acids methionine and cysteine, inorganic sulfate, sulfur dioxide and organic sulfur compounds such glutathione, taurine and N-acetyl-methionine (to a lesser extent) are also important for the sulfur intake by sparing the required amounts of methionine and cysteine in the diet. The natural content of sulfur dioxide of food is far lower than the total sulfur content (Table 5.4). Sulfur dioxide is used for food conservation, and this in turn has led to the proposal of upper limit values for this sulfur compound (see Section 5.7 and Table 5.11). 

The breakdown of protein and amino acids in the intestinal tract and their enzymatic hydrolysis in cells releases sulfur from sulfur-containing proteins. The biological importance of sulfur partly involves the amino acids methionine, cysteine and taurine, and other metabolites such as glutathione and N-acetyl-methionine. Hence, sulfur plays biochemical and physiological... 

Acetyl-isopropyl benzol. Seep-Isopropylacetophenone Acetylmetacresol. See m-Cresyl acetate Acetyl methionine (INCI) N-Acetylmethionine. See N-Acetyl-L-methionine N-Acetyl-L-methionine... 

Synonyms N-Acetyl-L-2-amino-4-(methylthio) butyric acid Acetyl methionine (INCI) N-Acetylmethionine Methionamine L-Methionine, N-acetyl-... 

N-Acetyl-DL-methionine, compd. with (2,5-dioxo-4-imidazolidine) urea (1 1). See Allantoin acetyl methionine Acetylmethionyl methylsilanol elastinate CAS 227200-23-9... 

Formula C7H13NO3S C4H6N4O3 Uses Antistat, skin protectant, soothing agent in cosmetics, skin care, sun care Trade Name Synonyms Tri-K Allantoin Acetyl Methionine t[Tri-K Ind. http //www.tri-k.com]... 

Allantoin N-acetyl-DL-methionine. See Allantoin acetyl methionine Allantoin ascorbate... 

Definition Cobalt salt of acetyl methionine Empirical C7H13NO3S ViCo Uses Catalyst for oxidoreduction detoxification transpeptidization keratin/enzyme/hormones formation promoter skin moisturizer antiperspirant agent in cosmetics... 

Tri-K Allantoin Acetyl Methionine. See Allantoin acetyl methionine Tri-K Allantoin. See Allantoin Tri-K HKP. See Hydrolyzed hair keratin Tri-K HMP. See Hydrolyzed glycosaminoglycans... 

Sodium lauroyl sarcosinate antistat, shaving soaps Lauramide DEA antistat, skin care Allantoin acetyl methionine ... 

Allantoin acetyl methionine Hydrolyzed milk protein Hydrolyzed yeast protein antistat, sunburn treatments Pyridoxine dicaprylate Pyridoxine dipalmitate antistat, sunscreens Dioctyidodecyl dodecanedioate antistat, surface coatings (3-Lauramidopropyl) trimethyl ammonium methyl sulfate... 

Allantoin acetyl methionine Cetearyl behenate Cocoa (Theobroma cacao) butter protectant, skin suppositories Shea butter (Butyrospermum parkii) protectant, skin veterinary preps. 

Allantoin acetyl methionine Tri-K Allantoin Acetyl Methionine 4207-41-4... 

Figure 15.3. Lineweaver-Burk plots for the inhibition of aminopeptidase-catalyzed proteolysis of methionine enkephalin by acetylated methionine enkephalin inhibited reaction (solid line) and the noninhibited reaction (dotted line). (Reproduced from ref. 6 by permission of Elsevier Science, copyright 2000.)...

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