Acetyl-L-carnitine

Herzberg U, Sagen J (2001) Peripheral nerve exposure to HIV viral envelope protein gpl20 induces neuropathic pain and spinal gliosis. J Neuroimmunol 116(l) 29-39 Herzmann C, Johnson MA et al (2005) Long-term effect of acetyl-L-carnitine for antiretroviral toxic neuropathy. HIV Clin Trials 6(6) 344-350... [Pg.80]

Youle M, Oslo M (2007) A double-blind, parallel-group, placebo-controUed, multicentre study of acetyl L-carnitine in the symptomatic treatment of antiretroviral toxic neuropathy in patients with HIV-1 infection. HIV Med 8(4) 241-250... [Pg.86]

Pettigrew JW, Levine J and McClure RJ (2000). Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties Relevance for its mode of action in Alzheimer s disease and geriatric depression. Molecular Psychiatry, 5, 626-632. [Pg.279]

Spagnoh A, Lucca U, Menasce G Long-term acetyl-L-carnitine treatment in Alzheimer s disease. Neurology 41 1726-1732, 1991... [Pg.748]

Two EPMEs based on macrocyclic glycopeptide antibiotics—vancomycin and teicoplanin—were designed for the assay of acetyl-L-carnitine [44]. The linear concentration ranges for the proposed electrodes were 10 5-10-2 mol/L for the vancomycin-based electrode and 10 4-10-2 mol/L for the teicoplanin-based electrode, with slopes of 58.1 and 55.0mV/p(acetyl-L-camitine), respectively. The enantioselectivity was determined over D-carnitine. [Pg.65]

Acetic acid 257 Acetyl-l-carnitine 65 Acetylcholinesterase 312, 314, 687 inhibition 344 inhibitors 689... [Pg.959]

Gross, C.J., L.M. Henderson, and D.A. Savaiano. 1986. Uptake of L-camitine, D-carnitine and acetyl-L-carnitine by isolated guinea-pig enterocytes. Biochim Biophys Acta 886 425. [Pg.33]

The involvement of oxidative stress in AD has opened a new door for potential therapeutic targets. In this regard, several antioxidants are currently in clinical trials such as Idebenone, a-Lipoic acid, acetyl-L-carnitine (ALC), vitamin E, vitamin C, flavonoids, P-carotene, gingko biloba, and metal-chelating agents. Idebenone is a metabolic antioxidant and is normally synthesized as part of the mitochondrial oxidative phosphorylation system. Improvements in clinical status after treatment with idebenone have been shown in a dose-dependent manner compared to placebo and tacrine (Thai et al., 2003). [Pg.618]

Depression and cognitive decline are the two most common mental ailments that are treated with nutraceuticals. The most commonly available products for mental health include SAMe, DHEA, soy isofiavones, acetyl-L-carnitine, and n-3-fatty acids, particularly DHA. [Pg.2439]

Acetyl-L-carnitine can easily cross the blood-brain barrier, and it appears to be well tolerated and... [Pg.2440]

Acetyl-L-carnitine has been shown to cause a slowdown in the decline of cognitive measures in a number of studies conducted on subjects with mild Alzheimer s disease or mild cognitive impairment. However, one of the most recent double-blind trials conducted on its use in Alzheimer s showed very little difference between acetyl-L-carnitine and placebo. A recent metaanalysis of all the double-blind controlled clinical trials of acetyl-L-carnitine concentrated on patients who had mild cognitive impairment or mild Alzheimer s, and found that of 21 studies conducted, 17 showed that it had a positive effect on patients this however included some unpublished trials. [Pg.2440]

Acetyl-L-carnitine appears to have been well tolerated at doses of 1.5-3 g/day in all studies. Side-effect profiles appear to have been similar to those of placebo, with body odor, increased appetite, rash, and restlessness reported.t ... [Pg.2440]

Montgomery, S.A. Thai, L.J. Amrein, R. Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer s disease. Int. Clin. Psychopharmacol. 2003, 18 (2), 61-71. [Pg.2449]

CTN1 (SLC22A4) Human TEA, MPP+, L-carnitine, acetyl-L-carnitine Drugs pyrilamine, quinidine, verapamil D-carnitine, nicotine Drugs cephaloridine, cimetidine, procainamide, quinine... [Pg.56]

Trade names Acetyl-L-carnitine Aplegin B(t)Factor Carnitine Carnitor L-Carnipure Levocarnitine Propionyl-L-carnitine Vitacarn Vitamin BM... [Pg.325]

L-camitine Acetyl-L-carnitine, Aplegin, B(t)Factor, Carnitine, Carnitor, L-Carnipure, Levocarnitine, Propionyl-L-... [Pg.659]

Jiang X, Tian Q, Wang Y, Zhou XW, Xie JZ, Wang JZ et al (2011) Acetyl-L-carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C. J Neurochem 118 864-878... [Pg.540]

Blokland, A., Bothmer, J., Honig, W., Jolles, J. (1993). Behavioural and biochemical effects of acute central metabolic inhibition Effects of acetyl-l-carnitine. European Journal of Pharmacology, 235, 275-281. [Pg.92]

Hagen, T., Ingersoll, R. T., Wehr, C. M., Lykkesfeldt, J., Vinarsky, V., Bartholomew, J. C., Song M. H. and Ames B. N. Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity. Proceedings of the National Academy of Sciences USA 95 9562-9566 1998. [Pg.359]

L-Form hydrochloride. C H 8C N04, acetyl-L-carnitine chloride, [evacecarnine hydrochloride, ST-200, Alcar, Brani-gent Nicetile. Stable crystals, mp 187 (dec). Also reported as small rod-shaped crystals from butanol, mp 181 (Srrack). [ — 26.9" (c — 9), [a]ff —28 (o = 2 in water). Very sol in water, sol in alcohol. Practically insol in ether. therap cat Nootropic,... [Pg.14]

Calvani, M. and Carta, A. (1991) Clues to the mechanism of action of acetyl-L-carnitine in the central nervous system. Dementia 2 1-6. [Pg.483]

De Simone, R., Ramacci, M.T. and Aloe, L. (1991) Effect of acetyl-L-carnitine on forebrain cholinergic neurons of developing rats. Int. J. Dev. Neurosci. 9 39—46. [Pg.485]

Dowson, J.H., Wilton-Cox, H., Cairns, M.R. and Ramacci, M.T. (1992) The morphology of lipopigment in rat Purkinje neurons after chronic acetyl-L-carnitine administration a reduction in aging-related changes. Biol. Psychiatry 32 179-187. [Pg.486]

Petruzzella, V., Baggetto, L.G., Penin, F., Cafagna, F., Ruggiero, F.M., Cantatore, P and Gadaleta, M.N. (1992) In vivo effect of acetyl-L-carnitine on succinate oxidation, adenine nucleotide pool and lipid composition of synaptic and non-synaptic mitochondria from cerebral hemispheres of senescent rats. A rc/i. Gerontol. Geriatr. 14 131-144... [Pg.500]

Ramacci, M.T., De Rossi, M., Lucreziotti, M.R., Mione, M.C. and Amenta, F. (1988) Effects of long-term treatment with acetyl-L-carnitine on structural changes of ageing rat brain. Drugs Exp. Clin. Res. 14 112-115. [Pg.501]

Rosenthal, R.E., Williams, R., Bogaert, Y.E., Getson, P.R. and Fiskum, G. (1992) Prevention of post-ischemic canine neurological injury through potentiation of brain energy metabolism by acetyl-L-carnitine. Stroke 23 1312-1318. [Pg.502]

Taglialatela, G., Angelucci, L., Ramacci, M.T., Werrbach-Perez, K., Jackson, G.R. and Perez-Polo, J.R. (1992) Stimulation of nerve growth factor receptors in PC 12 by acetyl-L-carnitine. Biochem. Pharmacol. 44 577-585. [Pg.506]

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