Acetate Cream

The cream is a soft, white, nonstaining, water-miscible, anti-infective cream for topical administration to bum wounds. Cream spreads easily and can be washed off readily with water. It has a slight acetic odor. Each gram of cream contains mafenide acetate equivalent to 85 mg of the base. The cream vehicle consists of cetyl alcohol, 

The lotion contains 0.005 g of malathion per milliliter in a vehicle of isopropyl alcohol (78%), terpineol, dipentene, and pine needle oil. The chemical name of malathion is 

Liquefy eugenol, menthol, and peppermint oil together by mixing all three items. 

Warm gently to 35° 40°C if necessary. Strain into the container while mixing. Gently melt metaphen ointment base and strain into the container while mixing. 

2-amino-2-methyl-l-propanol, methylparaben, butylpara-ben, perfume, and water to form a nongreasy lotion, which is the highly purified gamma isomer of 1, 2, 3, 4, 5, 6, hexachlorocyclohexane. 

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Hydrocortisone acetate Cream, lotion, ointment All strengths Low VII... 

Mafenide is a topical sulfonamide that has been used for the treatment of burns but is now obsolete. Its adverse effects include hyperchloremic metabolic acidosis and (possibly) methemoglobinemia (1). Pulmonary insufficiency has been ascribed to mafenide acetate cream (SEDA-8,160). 

Methylprednisolone acetate Cream, ophthalmic oint-(Medrol Acetate) ment, enema, ointment,... 

For purification, transfer the acid to a 150 ml. flask containing 60 ml. of water, boil the mixture under reflux, and then add acetic acid in 5 ml. portions down the condenser until almost all the solid has dissolved avoid an excess of acetic acid by ensuring that the solvent action of each addition is complete before the next portion is added. A small suspension of insoluble impurity may remain. Add 2 g. of animal charcoal, boil the solution again for 10-15 minutes, and then filter it through a preheated Buchner funnel. Cool and stir the filtrate, which will deposit pale cream-coloured crystals of the acid. Collect as before and if necessary repeat the recrystallisation. Yield of pure acid, 9 g. m.p. 227-229°. 

As of 1991 in the United States, OTC antiacne preparations may contain only a few active dmgs, for example, sulfur [7704-34-9] resorcinol acetate [102-29-4], resorcinol [108-46-3], salicylic acid [69-72-7], and some combinations (52). OTC anti-acne constituents maybe included in a variety of conventional cosmetic preparations, which then become OTC dmgs. These include lotions, creams, solutions, facial makeups, facial cleansers (including abrasive cleansers), and astringents. Products must contain the specified dmgs at the designated concentrations. Compositions of antiacne products have beenpubhshed (53). 

Cyclopropyltriphenylphosphonium Bromide (5). The lactone salt is pyrolyzed by placing it in a round-bottom flask fitted with an adaptor attached to a vacuum source (aspirator is sufficient). The flask is heated (oil bath) to 180-190° for 48 hours. The residue is a virtual quantitative yield of the tan product, which may be crystallized from ethyl acetate giving cream crystals, mp 189-190°. An alternate setup is convenient if a drying pistol (Abderhalden) is available. The compound is placed in the pistol, which is then evacuated. Decalin (bp approx. 187°) is refluxed over the pistol to provide the heating source. The work-up is the same. 

Van de Vaart et al. [45] used a thin-layer chromatographic method for the analysis of miconazole and other compounds in pharmaceutical creams. The drugs in creams were analyzed by thin-layer chromatography on silica gel plates with ether in pentane-saturated chamber or with butanol-water-acetic acid (20 5 2). Both active ingredients and vehicle components were detected and Rf values of 67 active ingredients are tabulated. Additional eluents may be needed to separate certain combinations of ingredients. 

Acidulants. The other component of any system of chemical leavening based on sodium hydrogen carbonate is an acid. The original acidulants were sour milk (lactic acid), vinegar (acetic acid), lemon juice (citric acid) and cream of tartar (potassium acid tartrate). All of these will react immediately on mixing so that the carbon dioxide is released straight away. The product had to be baked before the carbon dioxide escaped from the batter or product. The only delay possible was that allowed by the batter viscosity. 

The indole-3-acetic acid, which is cream-colored, is of high purity. If further purification is desired, it may be done con-... 

A chromatographic mobile phase consisting of acetonitrile/0.1 M sodium acetate buffer pH 4.0 (70 30) is prepared. Separate stock solutions in 250 ml of chromatographic mobile phase containing miconazole nitrate (200 20 mg) and econazole nitrate (200 20 mg) (internal standard) are prepared. 25 ml of econazole nitrate stock solution is transferred to five 100 ml volumetric flasks and varying amounts of miconazole stock solution 15, 20, 25, 30 and 35 ml are added to the five flasks. The flasks containing the calibration series are diluted to volume with mobile phase. A sample of cream containing 20 mg miconazole nitrate is shaken with 25 ml... 

Analysis Is carried out on a cream stated to contain 2% w/w of both miconazole and hydrocortisone. An ODS column is used with a mobile phase consisting of acetonitrile/ acetate buffer pH 4.0 (70 30) and the eluent is monitored at 220 nm. A narrow range calibration curve, within 20% of the expected concentration of each analyte in the sample extract was prepared for each analyte by plotting the ratio of the areas of the analyte peaks against fixed amounts of the internal standards for both analytes. The internal standards used were econazole and hydrocortisone 21-acetate for miconazole and hydrocortisone, respectively. 

Determination of glucocorticoids by HPLC m. Application to ointments a cream containing cortisone acetate, dexamethasone acetate, fluorometholone and betamethasone valerate. (167)... 

System (6) was recommended for the analysis of hydrocortisone, cortisone, and their acetates in pharmaceutical preparations, as well as their separation from a number of impurities and decomposition products [154]. The sample (creams, ointments, lotions, or suppositories) was extracted with hot ethanol prior to introduction into the HPLC system. 

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