Dexamethasone 21-acetate

The preparation of dexamethasone acetate is described in U.S. Patent 3,007,923 as follows. 1.5 cc of dimethylformamide and 1.5 cc of anhydrous hydrofluoric acid are admixed and... 

Fontego - Bumetanide Fonzylane - Buflomedil Forane Isoflurane Fordex - Tolbutamide Fordiuran Bumetanide Foreart Inosine Forenol -Niflumic acid Forhistal Dimethindene maleata Foristal - Dimethindene maleate Formaftil - Formocortal acetate Formulex Dicyclomine HCI Fortabol -Methenolona acetate Fortabolin - Nandrolone decanoate Fortapen - Ampicillin Fortasec - Loperamide HCI Fortecortin Dexamethasone acetate Fortesul Sulfameter... 

Dexamethasone (147) was photolysed in chloroform-methanol to the lumipro-duct (152) [98], Irradiation of dexamethasone acetate (148) in methanol gave a mixture of (153), (157) and (163). The lumiproduct (152) was shown to be an intermediate for (158) and (164) [101]. Betamethasone (149) was photolysed under similar conditions to give the lumiproduct (154) [102]. Betamethasone-17-valerate has been shown to photodegrade in sunlight, although the products were not identified [103]. 

Reversed-phase liquid chromatographic determination of dexamethasone acetate and cortisone acetate in bulk drugs dosage forms. (164)... 

Determination of glucocorticoids by HPLC m. Application to ointments a cream containing cortisone acetate, dexamethasone acetate, fluorometholone and betamethasone valerate. (167)... 

A good initial approach is to study the behavior of known synthetic precursors, drug analogs or degradates. In our previous example, dexamethasone acetate, one can readily purchase compounds such as cortisone, cortisone acetate, dexamethasone alcohol, dexamethasone-17-keto analog, prednisolone alcohol, and so on. Their chromatographic responses, relative to the compound of interest, will indicate which structural modifications are detec-... 

The preparation of dexamethasone acetate is described in US Patent 3,007,923 as follows. 1.5 cc of dimethylformamide and 1.5 cc of anhydrous hydrofluoric acid are admixed and treated with 480 mg of 9p,lip-epoxy-17a-hydroxy-21-acetoxy-16a-methyl-A1-4-pregnadiene-3,20-dione (prepared according to E.P. Oliveto et al, J. Am. Chem. Soc., 80, 44331, 1958). The steroid dissolves in about 15 minutes. The reaction mixture is shaken for two hours at a temperature between 0 and +5°C, and then poured into 75 cc of... 

L. L. Ng, Reverse phase liquid chromatographic determination of dexamethasone acetate in cortisone acetate in bulk drug substances and dosage forms Method development, J. Assoc. Off. Anal. Chem., 70 829(1987). 

Fig. 6 LC/MS/MS chromatograms of 5 pg/mL (LOQ) of corticosteroids spiked in plasma (a) budesonide (b) dexamethasone (c) triamcinoloneacetonide, and dexamethasone acetate (Reproduced with permission from American Chemical Society)...

For parenteral administration in intensive therapy or in emergendes, the sodium phosphate ester may be given intravenously by injection or infusion, or intramuscularly by injection. Dexamethasone sodium phosphate is also used in the treatment of cerebral edema caused by malignancy. The sodium phosphate ester is given by intra-articular, intra-lesional or soft tissue injection. Dexamethasone acetate may be given by intramuscular injection in conditions where corticosteroid treatment is indicated, but a prompt response of short duration is not required. 

Clofazimine 225d Dexamethasone Acetate 234-239d Sulfamerazine ... 

Dexamethasone acetate (Dalalone DP, Forest, Decadron-LA, Merck) and Dexamethasone sodium phosphate (Merck) are available as a suspension or a solution. These dexamethasone formulations contain creatine or creatinine as additives. 

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