Acetaminophen-induced liver injury

Maechler, P., Kennedy, E. D., Wang, H., and Wollheim, C. B., 1998, Desensitization of mitochondrial Ca2+ and insulin secretion responses in the beta cell, J. Biol. Chem. 273, pp. 20770-20778 Masubuchi, Y., Nakayama, S., and Horie, T., 2002, Role of mitochondrial permeability transition in diclofenac-induced hepatocyte injury in rats, Hepatology 35, pp. 544-551 Masubuchi, Y., Suda, C., and Horie, T., 2005, Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice, J. Hepatol. 42, pp. 110-116 Mathai, J.P., Germain, M., Marcellus, R. C., and Shore, G. C., 2002, Induction and endoplasmic reticulum location of BIK/NBK in response to apoptotic signaling by E1A and p53, Oncogene 21, pp. 2534-2544... [Pg.502]

The reaction that produces NAPQI generates superoxide anions as a by-product. Interactions of NAPQI with other cellular molecules also generate reactive oxygen species, leading to oxidative stress on the hepatocyte (Zimmerman, 1999 Dahm and Jones, 1996). The role of calcium and Kupffer cell activation have been impUcated as contributing factors for acetaminophen-induced liver injury by producing reactive nitrogen species (Treinen-Moslen, 2001). [Pg.555]

Acetaminophen provides another example of an analogous in vitro multi-hit process. Previously, most of the acetaminophen-induced hepatotoxicity research focused on the reactive metabolite of acetaminophen, which led to covalent protein modification (reviewed in Reference 76). Recently, it was realized that mitochondrial damage and oxidative stress may be the second-hit leading to acetaminophen-induced liver injury.7778 This is substantiated by animal studies where partial knockdown of SOD2 in rats, as well as mice heterozygous to SOD2 were more susceptible to acetaminophen-induced liver injury than wild type animals.79-80... [Pg.63]

Hanawa N, Shinohara M, Saberi B, Gaarde WA, Han D, Kaplowitz N. Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury. Biol Chem. 2008 283(20) 13565-13577. [Pg.74]

Silva VM, Chen C, Hennig GE, et al Changes in susceptibility to acetaminophen-induced liver injury by... [Pg.206]

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Masson MJ, Carpenter LD, Graf ML, Pohl LR (2008) Pathogenic role of natural killer T and natural killer cells in acetaminophen-induced liver injury in mice is dependent on the presence of dimethyl sulfoxide. Hepatology 48 889-897... [Pg.24]

Bourdi M, Eiras DP, Holt MP, Webster MR, Reilly TP, Welch KD, Pohl LR (2007) Role of IL-6 in an IL-10 and IL-4 double knockout mouse model uniquely susceptible to acetaminophen-induced liver injury. Chem Res Toxicol 20 208-216 Britschgi M, Steiner UC, Schmid S, Depta JP, Senti G, Bircher A, Burkhart C, YawalkarN, PichlCT WJ (2001) T-cell involvement in drug-induced acute generalized exanthematous pustulosis. J Clin Invest 107 1433-1441... [Pg.222]

Ishida Y, Kondo T, Tsuneyama K, Lu P, Takayasu T, Mukaida N (2004) The pathogenic roles of tumor necrosis factor receptor p55 in acetaminophen-induced liver injury in mice. J Leukoc Biol 75 59-67... [Pg.225]

Hu B, Colletti LM (2008) Stem cell factor and c-kit are involved in hepatic recovery after acetaminophen-induced liver injury in mice. Am J Physiol Gastrointest Liver Physiol 295... [Pg.305]

Masubuchi Y, Suda C, Horie T (2005) Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice. J Hepatol 42(1) 110-116 Matsumaru K, Ji C, Kaplowitz N (2003) Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes. Hepatology 37(6) 1425-1434 Maurer U, Charvet C, Wagman AS, Dejardin E, Green DR (2006) Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell 21(6) 749-760... [Pg.307]

Bajt ML, Knight TR, Farhood A, Jaeschke H (2003) Scavenging peroxynitrite with glutathione promotes regeneration and enhances survival during acetaminophen-induced liver injury in mice. J Pharmacol Exp Ther 307 67-73... [Pg.351]

Baines CP, Kaiser RA, Purcell NH, Blair NS, Osinska H, Hambleton MA, Brunskill EW, Sayen MR, Gottlieb RA, Dom GW, Robbins J, Molkentin JD (2005) Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature 434 658-662 Bajt ML, Knight TR, Farhood A, Jaeschke H (2003) Scavenging peroxynitrite with glutathione promotes regeneration and enhances survival during acetaminophen-induced liver injury in mice. J Pharmacol Exp Ther 307 67-73... [Pg.395]

Latchoumycandane C, Goh CW, Ong MM, Boelsterli UA (2007) Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury. Hepatology 45 412-421... [Pg.401]

Rumack BH, Peterson RC, Koch GG, Amara lA (1981) Acetaminophen overdose. 662 cases with evaluation of oral acetylcysteine treatment. Arch Intern Med 141 380-385 Sakaida I, Kayano K, Wasaki S, Nagatomi A, Matsumura Y, Okila K (1995) Protection against acetaminophen-induced liver injury in vivo by an iron chelator, deferoxamine. Scand J Gastroenterol 30 61-67... [Pg.404]

Salas VM, Corcoran GB (1997) Calcium-dependent DNA damage and adenosine 3 5 -cyclic monophosphate- independent glycogen phosphorylase activation in an in vitro model of acetaminophen-induced liver injury. Hepatology 25 1432-1438 Salminen WF Jr, Voellmy R, Roberts SM (1998) Effect of N-acetylcysteine on heat shock protein induction by acetaminophen in mouse liver. J Pharmacol Exp Ther 286 519-524 Schiodt FV, Ott P, Christensen E, Bondesen S (2002) The value of plasma acetaminophen half-life in antidote-treated acetaminophen overdosage. Clin Pharmacol Ther 71 221-225 Schnellmann JG, Pumford NR, Kusewitt DF, Bucci TJ, Hinson JA (1999) Deferoxamine delays the development of the hepatotoxicity of acetaminophen in mice. Toxicol Lett 106 79-88 Shen HM, Pervaiz S (2006) TNF receptor superfamily-induced cell death redox-dependent execution. FASEB J 20 1589-1598... [Pg.404]

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