Acute generalized exanthematous pustulosis

Acute generalized exanthematous pustulosis due to a glucocorticoid has been reported (SEDA-21, 416 316). 

Demitsu T, Kosuge A, Yamada T, Usui K, Katayama H, Yaoita H. Acute generalized exanthematous pustulosis induced by dexamethasone injection. Dermatology 1996 193(l) 56-8. 

Oskay T. Acute generalized exanthematous pustulosis induced by simvastatin. Clin Exp Dermatol 2003 28 558-9. 

Acute generalized exanthematous pustulosis occurred in a 28-year-old man with ulcerative colitis taking sulfasalazine (92). A patch test was negative, but the lymphocyte stimulation assay for sulfasalazine showed a stimulation index of 541% (controls were not mentioned). 

Ogoshi M, Yamada Y, Tani M. Acute generalized exanthematic pustulosis induced by cefaclor and acetazo-lamide. Dermatology 1992 184(2) 142-4. 

Escallier F, Dalac S, Foucher JL, Lorcerie B, Lucet A, Lambert D. Pustulose exanthematique aigue generalisee imputabilite a I imipeneme (Tienam). [Acute generalized exanthematic pustulosis. Imputability of imipenem (Tienam).] Ann Dermatol Venereol 1989 116(5) 407-9. 

Chromium picohnate has caused acute generalized exanthematous pustulosis (17). 

Machet L, Martin L, Machet MC, Lorette G, VaiUant L. Acute generalized exanthematous pustulosis induced by dextropropoxyphene and confirmed by patch testing. Acta Derm Venereol 2000 80(3) 224-5. 

SED-13, 513) (SEDA-18, 215) (SEDA-22, 216). Three cases of skin reactions (hypersensitivity syndrome reaction, pruritic exanthematous eruption, and acute generalized exanthematous pustulosis) possibly induced by diltiazem have been described and the literature on skin reactions associated with calcium antagonists has been reviewed. The number of diltiazem-induced cutaneous events was significantly greater than those induced by either nifedipine or verapamil. However, there was no difference in the proportion of serious cutaneous adverse events due to any of these three drugs (11). 

Acute generalized exanthematous pustulosis in an 82-year-old woman was confirmed as being due to diltiazem by a positive patch test (15). 

A man developed acute generalized exanthematous pustulosis while taking furosemide (18). A positive lymphocyte transformation test suggested an immunological mechanism. 

Noce R, Paredes BE, Pichler WJ, Krahenbuhl S. Acute generalized exanthematic pustulosis (AGEP) in a patient treated with furosemide. Am J Med Sci 2000 320(5) 331-3. 

Acute, generalized, exanthematous pustulosis has been associated with clindamycin (41). 

Schwab RA, Vogel PS, Warschaw KE. Clindamycin-induced acute generalized exanthematous pustulosis. Cutis 2000 65(6) 391-3. 

Acute generalized exanthematous pustulosis has been attributed to topical hndane (11). 

Acute generalized exanthematous pustulosis associated with terbinafine has been described in two patients (47,49). Both presented within 7-10 days after starting to take terbinafine with generalized pustular dermatosis and leukocytosis fever was a presenting symptom in one patient. Treatment with systemic corticosteroids was successful in both cases. 

In another case of acute generalized exanthematous pustulosis attributed to terbinafine (250 mg/day), epicutaneous and intracutaneous skin tests were negative, and there was no evidence of viral infection (51). 

Condon CA, Downs AM, Archer CB. Terbinafine-induced acute generalized exanthematous pustulosis. Br J Dermatol 1998 138(4) 709-10. 

Kempinaire A, De Raeve L, Merckx M, De Coninck A, Bauwens M, Roseeuw D. Terbinafine-induced acute generalized exanthematous pustulosis confirmed by a positive patch-test result. J Am Acad Dermatol 1997 37(4) 653-5. 

Trueb RM, Burg G. Acute generalized exanthematous pustulosis due to doxycycline. Dermatology 1993 186(l) 75-8. 

Acute generalized exanthematous pustulosis (AGEP) Allergic reactions... 

Acute generalized exanthematous pustulosis (AGEP) (2003) Poszepczynska-Guigne E +, Ann Dermatol Venereol I 30(4), 439 Erythema (< 1%)... 

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