Acetaminophen-induced hepatotoxicity

Hinson, J.A. Reid, A.B. McCullough, S.S. James, L.P. (2004). Acetaminophen-induced hepatotoxicity role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition. Drug Metabolism Reviews, Vol.36, No. 3-4, (January 2004), pp. 805-822, ISSN 0360-2532. 

Jaeschke, H. (1990). Glutathione disulfide formation and oxidant stress during acetaminophen-induced hepatotoxicity in mice in vivo-, the protective effect of allopurinol. J. Pharmacol Exp. Ther. 255, 935-941. 

Dambach, D.M. et al., Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotoxicity in the mouse, Hepatology, 35, 1093, 2002. 

Lin MC, Wang EJ, Patten C, et al. Protective effect of diallyl sulfone against acetaminophen-induced hepatotoxicity in mice. J Biochem Toxicol 1996 11 11-20. 

James LP, Mayeux PR, Hinson JA. Acetaminophen-induced hepatotoxicity. Drug Metab Dispos. 2003 31 1499-1506. 

Makin AJ, Williams R (1997) Acetaminophen-induced hepatotoxicity predisposing factors and treatments. Adv Intern Med 42 453-483. 

Reid AB, Kurten RC, McCullough SS, Brock RW, Hinson JA. Mechanisms of acetaminophen-induced hepatotoxicity Role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes. J Pharmacol Exp Ther 2005 312 509-16. 

Zhang J, Huang W, Chua SS, Wei P, Moore DD. Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. Science 2002 298 422-4. 

Hinson JA, Pohl LR, Monks TJ, Gillette JR. Acetaminophen-induced hepatotoxicity. Life Sci 1981 29(2) 107-16. 

Cohen SD and Khairallah EA. Selective protein arylation and acetaminophen-induced hepatotoxicity. Drug Metabolism Review... 

Acetaminophen provides another example of an analogous in vitro multi-hit process. Previously, most of the acetaminophen-induced hepatotoxicity research focused on the reactive metabolite of acetaminophen, which led to covalent protein modification (reviewed in Reference 76). Recently, it was realized that mitochondrial damage and oxidative stress may be the second-hit leading to acetaminophen-induced liver injury.7778 This is substantiated by animal studies where partial knockdown of SOD2 in rats, as well as mice heterozygous to SOD2 were more susceptible to acetaminophen-induced liver injury than wild type animals.79-80... 

Yoshikawa Y, Morita M, Hosomi H, et al. Knockdown of superoxide dismut-ase 2 enhances acetaminophen-induced hepatotoxicity in rat. Toxicology. 2009 264(l-2) 89-95. 

Liu J, Li C, Waalkes MP, Clark J, Myers P, et al. 2002. The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced hepatotoxicity in mice. Hepatology. Submitted... 

Walker RM, McElligott TF, Power EM, et al. Increased acetaminophen-induced hepatotoxicity after chronic ethanol consumption in mice. Toxicology 1983 28(3) 193 206. 

Roberts, J. C., Nagasawa, H. T., Zera, R. T., Fricke, R. F., Goon, D. J. W. Prodrugs of L-cysteine as protective agents against acetaminophen-induced hepatotoxicity. 2-(Polyhydroxyalkyl)- and 2-(polyacetoxyalkyl)thiazolidine-4(/ )-carboxylic acids. J. Med. Chem. 1987,30,1891-1896. 

Although young children have an inherently lower risk of acetaminophen-induced hepatotoxicity, these patients should be managed in the same manner as adults. When acetaminophen plasma concentrations predict that toxicity is probable, young children should receive acetylcysteine in the dosing regimen described previously. ... 

Makin AJ, Wendon J, Williams R. A 7-year experience of severe acetaminophen-induced hepatotoxicity (1987-1993). Gastroenterology 1995 109 1907-1916. 

GIBSON, F.D., PUMFORD, N.R., SAMOKYSZYN, V. M. and HINSON, J.A. (1996) Mechanism of acetaminophen-induced hepatotoxicity Covalent binding versus oxidative stress. Chem. Res. 

Liu ZX, Kaplowitz N (2006) Role of innate immunity in acetaminophen-induced hepatotoxicity. Expert Opin Drug Metab Toxicol 2 493-503... 

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