Acetamide isopropyl

Diisopropyl ether, see Isopropyl ether Dimethoxymethane, see Methylal Dimethyl acetamide Dimethylamine... 

For example, acetyladamantane and isopropyl methyl ketone gave 1-adamantyl-acetamide in 85% yield and N-acetyl-isopropylamine in 46% yield, respectively [79]. A similar a-cleavage was observed in the electrochemical oxidation of the a-branched cyclic ketone (43) using Et3N-5HF as an electrolyte (Scheme 16) [81]. 

This paper traces in some detail the path which led to the discovery of a new class of herbicides, the 2-(5-oxo-2-imidazolin-2-yl)arylcarboxylates. The journey started when it was found that a phthalimide, a-isopropyl-a-methyl-l,3-dioxo-2-isoindoline-acetamide, had sufficient herbicidal activity to warrant further synthesis effort. This work led to a series of analogs essentially devoid of herbicidal activity yet possessing interesting plant growth regulating effects. Further chemical modifications resulted in the synthesis of two new groups of compounds, imidazoisoindolediones and dihydro-imidazoisoindolediones, and the return of herbicidal activity. The imidazoisoindolediones were in turn transformed into o-(5-oxo-imidazo-lin-2-yl)benzoates, the first members of a very interesting new class of herbicides. 

Nitric acid. Sulfuric acid, N-Methylhydroxy acetamide Phosphorus oxytrichloride. Benzene, Neopentyl glycol. Pyridine, Petroleum ether. Ammonium fluoride Thiophosphorus trichloride. Benzene, Neopentyl glycol. Pyridine, Petroleum ether. Ammonium fluoride Nitric acid. Sulfuric acid. Glycerol, Magnesium sulfate Anhydrous hydrazine. Cyanogen bromide. Isopropyl alcohol. Sodium nitrite. Sodium bicarbonate. Copper nitrate trihydrate. Nitric acid. Diethyl ether... 

N, jV-Di(isopropyl)acetamide 41.6 Cyclohexylamine 9995 Dibutjl sulfoxide 5.0 4-Methylpyridine 130.0... 

Solvent manufacturer Honeywell Burdick Jackson [39] defines solvents as miscible if the two components can be mixed together in all proportions without forming two separate phases. A solvent miscibility chart (Figure 2.12) is a useful aid for determining which solvent pairs are immiscible and would therefore be potential candidates for use in LLE. More solvent combinations are miscible than immiscible, and more solvents are immiscible with water than with any other solvent. Solvents miscible with water in all proportions include acetone, acetonitrile, dimethyl acetamide, N,N-dimethylformamide, dimethyl sulfoxide, 1,4-dioxane, ethyl alcohol, glyme, isopropyl alcohol, methanol, 2-methoxyethanol, /V-methyI pyitoI idone. n-propyl alcohol, pyridine, tetrahydrofuran, and trifluoroacetic acid [40]. 

The first application of the AA process was the short and efficient synthesis of the paclitaxel (Taxol) side chain 32 (Scheme 4) [58]. The hydroxysulfonamide 31 crystallized directly from the reaction mixture (69% yield, 82% ee) and was transformed to 32 in two steps. The procedure was further improved when the acetamide-AA was discovered [22]. The hydroxyactamide 33 was easily obtained in good yield (71%) and excellent ee (99% ee) and removal of the N-protecting group was nearly quantitative. A direct benzamide-AA gave 34, the isopropyl ester of 32, in a single step, though with lower yield (46%) than the acetamide-AA [24]. 

Chloro-N-(3,3,3-trifluoro-2-hydroxy-l -isopropyl-propyl)-acetamide... 

Benzyloxycarbonylamino-2-oxy-6 phenyl-1,2-dihydro-l-pyridyl)-N-(2-t-butyldimethylsiloxy-3,3,3-trifluoro-l-isopropyl-propyl)acetamide... 

Poly(amino acid)s (PAAs) have also been used in drug delivery PEO-(l-aspartic acid) block copolymer nano-associates , formed by dialysis from a dimethyl acetamide solution against water, could be loaded with vasopressin. PLA-(L-lysine) block copolymer microcapsules loaded with fluorescently labelled (FITC) dextran showed release profiles dependent on amino acid content. In a nice study, poly(glutamate(OMe)-sarcosine) block copolymer particles were surface-grafted with poly(A-isopropyl acrylamide) (PNIPAAm) to produce a thermally responsive delivery system FITC-dextran release was faster below the lower critical solution temperature (LCST) than above it. PAAs are prepared by ring-opening polymerisation of A-carboxyanhydride amino acid derivatives, as shown in Scheme 1. 

The most important consideration in the selection of the filter is the compatibility of the hlter materials of constmction with the solvent. The solvents used in pharmaceutical processes can be very aggressive. They include acetone, methanol, ethanol, isopropyl alcohol (IPA), acetonitrile, dimethyl acetamide, dimethyl formamide (DMF), ethyl acetate, tetrahydrofuran (THF), methyl isobutyl ketone (MIBK), and methyl ethyl ketone (MEK). Filters with PTFE membranes and polypropylene supports are used in most applications. 

O.O-DIETHYL ESTER. S-ESTER WITH N-ISOPROPYL-2-MERCAPTO-ACETAMIDE PHOSP HORODITHIOIC ACID... 

Acetylation of horseradish peroxidase increased its half-life at 65°C fivefold and made it more tolerant to dimethyl-formamide, tetrahydrofuran, and methanol.91 Chymotrypsin is more active in organic media when immobilized than when it is just suspended.92 The selectivity of enzymes in organic media can vary with the solvent.93 The transesterification of racemic 1-phenylethanol with vinyl butyrate using subtilisin gave the best enantioselectivity in dioxane (61%) and the least in N-metby 1 acetamide (3%). Pretreatment of a lipase from Candida rugosa in isopropyl alcohol increased the activity slightly and the enantioselectivity by more than tenfold in the resolution of ester 9.5.94 The R isomer had 93.1% enantiomeric excess (ee) the S isomer 94.4%. 

Research in the area of (3-blockers presently seems to increase selectivity and potency toward (3j activity. Aryloxypropanolamines, where the traditional isopropyl and tert-butyl groups on the nitrogen atom give way to arylureas and acetamides (later), offer some promise. 

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