Mercapto-acetamide

O.O-DIETHYL ESTER. S-ESTER WITH N-ISOPROPYL-2-MERCAPTO-ACETAMIDE PHOSP HORODITHIOIC ACID... 

Nitration of pyrido[l,2-f>]cinnolin-6-ium hydroxide inner salt 17 (R = H) and its 2-acetamide derivative afforded its 2-nitro and 2-acetamido-3-nitro derivatives, respectively. The reaction of 17 (R = H) with iodine monochloride afforded the 2-iodo derivative. The 2-cyano derivative was obtained from the 2-bromo derivative of 17 (R = H) with Cu(I)CN. Treatment of 17 (R = H) with P4S10 afforded the 11-mercapto derivative 41 (74JHC125). 

Methazolamide Methazolamide, N-(4-methyl-2-sulfamoyl-l,3,4-thiadiazol-5-yliden) acetamide (21.2.3), is made by an intermediate product of acetazolamide synthesis— 2-acetylamino-5-mercapto-l,3,4-thadiazol (9.7.3). This is benzylated with benzylchloride at the mercapto group, forming 2-acetylamino-5-benzylthio-l,3,4-thiadiazole (21.2.1). Further methylation of the product with methyl iodide leads to the formation of N-(4-methyl-2-benzylthio-l,3,4-thiadiazol-5-yliden)acetamide (21.2.2). Oxidation and simultaneous chlorination of the resulting product with chlorine in an aqueous solution of acetic acid, and reacting the resulting chlorosulfonic derivative with ammonia gives (21.2.3) [5-7]. 

Mercapto-phenyl-acetamid entsteht analog durch Umsetzung mit Ammoniak515. 

Functionalized mercaptans and disulfides like 191, 2-mercapto-/V-[(4-phenyl-amino)phenyl]acetamide, 2,2,-dithiobis[vV-(4-phenylamino)phenyl]acetamide or 2-mercapto-4,6-bis(4-anilinophenyl)amino-I,3,5-triazine have been used to bind PD moieties into PO, EPDM or diene based rubbers via recombination of the respective thiyl and macroalkyl radicals generated mechanochemically [8, 295], The process was followed using 35S-labelled compounds. High level of binding of PD-moieties was found at 180°C with EPDM. The mode of the attachment of PD via sulfur atoms was confirmed using model compounds [295]. 

Examples in which the 2-position of the annelated pyrimidine is substituted include the following. 2-Aminopyrazine-3-thiocarboxamide and trifluoro-acetamide, boiled in ethanolic sodium ethoxide for 8 hr, produced a good yield of 4-mercapto-2-trifluoromethylpteridine (the HS— nature of the sulfur substituent was verified by 1H NMR)213 fusion of 4-aminoimidazole-... 

The hydroxyl group of the l,2-dioxan-3-ols could be substituted by a methoxyl, acetoxyl, and chloro group [73,167[. The Grignard reaction of the 3-methoxy-l,2-dioxane-4-carboxylates afforded the corresponding alcohols [80]. Further, the 4-bromoacetyl-3-methoxy-l,2-dioxanes could also be converted by the reaction of acetamide, hydrazines, thiomeas, thioamides, 4-amino-5-mercapto-1,2,4-triazole, and 2-aminothiophenol into heterocycle-substituted 1,2-dioxane derivatives [167]. 

Mercapto-A-(4-methoxyphenyl) acetamide, M-00033 2-Mercapto-3-(4-methoxyphenyl)-2-propenoic acid, M-00034 2-Mercapto-4-methylphenol, M-00035 2-Mercapto-A-(4-methylphenyl)acetamide, M-00036... 

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