Accomplishing goals with

Removal of the tri-wo-propylsilyl (TIPS) and tm-butyldimethylsilyl (TBS) protecting groups could be accomplished concomitantly with TBAF in tetrahydrofuran at 0 °C, but here competing elimination of the secondary bromide was observed. Better overall yields and cleaner conversion was observed when TBS ether was cleaved with 5 % aqueous HF in acetonitrile at 0 °C followed by removal of the acetylenic TIPS with TBAF under milder conditions of -78 °C.10 The diastereomers are not separated before the desilylation process therefore even a 3 1 mixture of E- and Z-enyne is obtained. Prelaureatin 4 and its F-isomer 17 are likewise goals in natural product synthesis. Crimmins and co-workers developed an own synthetic route to 4. The reaction sequence is similar up to aldehyde 55. Afterwards a Z-vinyl-iodide is selectively formed and the alkyne is introduced via a Sonogashira reaction. 

A new mathematical technique for processing 2D data, known as the filter diagonaliza-tion method (FDM), was recently developed by A. J. Shaka. The technique accomplishes goals similar to those aimed at in LP. In this method, even fewer time-incremented spectra, namely, two to four increments for an HMQC or HSQC experiment, are collected than with LP. FDM appears to be best suited for those heteronuclear chemical-shift-correlated experiments for which there are a limited number of v signals for any particular frequency V2 [e.g., for HMQC or HSQC spectra when the maximum number of v ( C) signals per U2( H) frequency is unity]. 

Tools are among the most archaeologically valuable artifacts. Their intrinsic value seldom approaches the expense of excavating and conserving them. However, as bearers of information, tools contain and convey information about the nature of the problems they were made to solve. Just as important, tools provide evidences of the definition of those problems and the choice of solutions. The choices we make of methods to accomplish goals and solve problems reflect our society s methods of problem identification and solving, and its attitudes toward materials and the proper ways to deal with them. Tools are excellent reflectors of patterning. 

The overall theme of this book is to put lower-level risks into the appropriate perspective and focus increased energy and resources on the most important or complex transportation issues. Figure 3.3 presents a risk assessment protocol that can be applied to accomplish this goal, with the first step being the identification and prioritization process. 

Another important service trend is the replacement of products with services. For example, telecommunications providers offer voice mail rather than selling answering machines. Another example is electronic order processing rather than paper processing. These service trends result in demater-iaUzation, the minimization of materials consumed to accomplish goals (Herman et al. 1989). 

The choice of an AAC system should rely primarily on the best interests of the person who will be using the system. Since outcomes and personal achievement will be related directly to the ability to communicate, the choice of a system will have lifelong implications. The process of choosing the most appropriate system is not trivial and can be accomplished best with a multidisciplinary team focusing on outcomes. Team members should realize that the interests of the individual served professionally are not necessarily aligned with those of the providers and/or payers of AAC services. The temptation to select a system that is easy to apply or inexpensive to purchase frequently exists, especially with untrained teams. Teams that identify outcomes and have the goal of achieving interactive communication make informed decisions. 

We recognize that one of the major challenges will be to accomplish these goals with an economically viable system. Today s economic approach to nuclear power is throu economies of scale. Our concept approaches the economic issue from a different perspective we rely on the economics of mass production, coupled with cost savings achieved from dramatically reduced onsite installation, operation and decommissioning costs, reduced site infiastructure requirements, and simplified type licensing to overcome the loss of economies of scale. 

The inoculation of chickens with non-pathogenic cultures of bacteria has been reported to reduce Salmonella populations in chickens (Nurmi and Rantala, 1973 Wierup et al, 1988 Rehe, 1991). Probiotic administration is quite similar in approach to competitive exclusion in that a specific bacterial culture, often lactic acid bacteria, is administered to live birds. The two procedures may also accomplish the same goals with respect to pathogen reduction. However, a tenet of probiotic administration has been that it improves animal growth (Jernigan et al., 1985). 

Abstract Selective functionalization of one specific C(sp )-H bond in a complex molecule without the assistance of a directing group represents the state of the art in organic synthesis and will be a dynamic topic in future. In the past decade, many excellent methods have been developed to accomplish this goal with transition-metal catalysts and even under metal-free conditions. In this chapter, we summarize the recent achievements in this realm during the past 5 years, including oxidative functionalization of a-C(sp )-H bonds adjacent to heteroatoms, allylic, benzylic, and unactivated aliphatic C(sp )-H bonds. The total redox-neutral C(sp )-H bond functionalization is also briefly introduced. 

---