Access and Acceptability

Fire fighting equipment should be mounted at heights that are easily accessible by the average person. This includes portable fire extinguishers, hose connections to fire hydrants, access to emergency shutoff valves, emergency stop/ESD push buttons, etc. 

Process control, valves and control panels should be easily accessible and viewable. ASTM standard F-l 166 provides graphical charts for the physical means to view and operable controls and instruments. 

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The parameters nominally at our disposal are the diameter of the reactor, the mass velocity, and the particle diameter. The problem of changing the scale will be discussed from the point of view of an engineer who wants to match the performance of two reactors of different diameters, and who must then choose a corresponding mass velocity and an accessible—and acceptable—combination of particle diameter and activity of catalyst. 

Finding 5-6. Although incineration is a robust, safe, and proven technology for the destruction of chemical agent, it is not the best technology for non-stockpile materials because access and acceptability are issues. 

The business measures its economic value via market share, value per customer, visits per time, and net earnings (Jambulingham et al., 2005). From the customer perspective, economic value delivers quality, reliability, servicing skills, time efficiency, accessibility, and acceptable pricing. Business measures include monitoring. 

An adequate characterization of the dose/exposure portion of reported dose—responses for lead requires discussion of the merits and limits of those exposure biomarkers which have traditionally been used and others which are relatively new and gaining favor. These two broad groups of exposure assessment instruments are further stratified in terms of temporal and toxicokinetic relationships for lead s associated toxic responses and in terms of accessibility and acceptability for routine use in the research and medical communities. 

It is difficult to give specific advice on this subject, as there is a very large range of industrial undertakings. The awareness for, and acceptability of, access is dependent on the types of goods to be moved and the frequency and method of movement. In some undertakings there is a major movement between different transport modes, which is concentrated either at ports or at major road/rail interchanges. 

Colleges and universities that accept online submissions appreciate the power of technology. Even schools that accept paper applications may scan them to create computer versions, and then shred the paper. The advantages of computerized applications are many. They may be sorted in countless ways, compared to one another, and compared with the school s admissions standards. Everyone in the admissions department can access and share all of the applications without photocopying or waiting for a file until it s their turn. This makes their job not only easier, but more time efficient as well. 

If risk management activities are used to permit the marketing of drugs that otherwise would be kept off because of serious safety concerns, and the activities are effective, the public will be better off. On the other hand, if risk minimisation tools are routinely applied to drugs that could be marketed without them, they could serve to deny access of physicians and patients to valuable and acceptably safe medicines. How the FDA will strike this balance remains to be seen. 

For HCS to be fully accepted by academia, several conditions will need to be fulfilled. Current HCS instruments are closed black boxes and their expensive maintenance contracts do not allow any hardware or software modifications for adaptation to the diverse needs of academic research. Academic research is typically more diversified than pharmaceutical industry research and the instruments need to be more customizable than they are now. In addition, the image and data formats need to be accessible and open. In academia data is shared between collaborators and will be analyzed with various, partly custom-made software. Therefore the data needs to be accessible and open. Lastly, the yearly costs of maintenance contracts and licenses are particularly difficult to finance in academic research that relies heavily on grants. Grants typically do not cover licensing costs or if they do, when the grant runs out, new sources of funding must be found. In reality, those costs must generally be covered by institutional funds. 

An area of current development is the nomenclature of organometallic compounds. Organometallic compounds of Main Group elements can, to a first approximation, be considered to be derivatives of hydrides, and the methods of substitutive nomenclature can be applied. Even then, the accessibility of different oxidation states, as with phosphorus(iii) and phosphorus(v), introduces complications. Transition metal organometallic compounds are even more difficult to treat, and the development of a unified, self-consistent and accepted and applied nomenclature is not easy. Witness the different ways (k, t and italicised symbols) for denoting donor atoms in ligands. 

A preliminary determination of the plant layout enables consideration of pipe runs and pressure drops, access for maintenance and repair and in the event of accidents and spills, and location of the control room and administrative offices. The preliminary plant layout can also help to identify undesirable and unforeseen problems with the preferred site, and may necessitate a revision of the site selection (Section 5.1). The proposed plant layout must be considered early in the design work, and in sufficient detail, to ensure economical construction and efficient operation of the completed plant. The plant layout adopted also affects the safe operation of the plant, and acceptance of the plant (and possibly any subsequent modifications or extensions) by the community. 

Validation test environment including hardware, software System security including passwords, network rights, functional security, physical security, modem access and virus protection Validation test environment including related documents, along with standard operating procedures, user manuals, and system development/ maintenance and documentation Validation assumptions, exclusions, and limitations Responsibilities matrix Validation data sets Acceptance criteria Expected results Execution of the validation plan Resolution of errors Documentation Training records... 

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