Abstract trials

In calculations of abstract trials, we may often reach variation limits for some factors, while for others there is a point in varying them. In such a case the former factors should be fixed on optimal levels, while the latter should be kept on moving to optimum. Movement to optimum is terminated if a researcher-experimenter thinks he has reached either the optimum or limitations in factor variation. 

An analysis of outcomes of movement along the gradient, or of abstract trials, indicates an efficient application of the method of steepest ascent since the obtained yield is 72.5%. It is pointless to continue movement to optimum because smaller yields are obtained. The obtained optimum is probably local since even that value of yield is far away from theoretical. The difference between the achieved and theoreti-... 

Efficiency of movement to optimum along the gradient is analyzed by means of the response value. In the case that obtained response values of abstract trials when moving to optimum are better then those response values of basic design of experiments, the method is efficient. To move efficiently to optimum, we may have these two results ... 

Grainger DL, Edgell ET, Andersen SW (1998b). Resource use and quality of life of olanzapine compared with risperidone results from an international randomized clinical trial. Abstract presented at 11th European College... 

Haringman JJ, Gerlag DM, Smeets TJ, et al. A randomized placebo controlled trial with an anti-MCP-1 (CCL2) monoclonal antibody in patients with rheumatoid arthritis [Abstract 519], Arthritis Rheum 2004 50(Suppl) S238. 

Cochrane Library. The Cochrane Library [44] includes The Cochrane Database of Systematic Reviews, a collection of regularly updated, systematic reviews of the effects of health care. It is maintained by contributors to the Cochrane Collaboration. Cochrane reviews are reviews mainly of randomized controlled trials. To minimize bias, evidence is included or excluded on the basis of explicit quality criteria. Data are often combined statistically, with meta-analysis, to increase the power of the findings of numerous studies, each too small to produce reliable results individually. Database of Abstracts of Reviews of Effectiveness is also included. It consists of critical assessments and structured abstracts of good systematic reviews published elsewhere. The Cochrane Controlled Trials Register with bibliographic information on controlled trials and other sources of information on the science of reviewing research and evidence-based health care are part of the Cochrane Library. It is commercially available on CD-ROM or the Internet. 

P. Frohna, S. Milwee, J. Pinkett, T. Lee, K. Moore-Perry, J. Chou, and R. H. Ellison in Results from a Randomized, Single-Blind, Placebo-Controlled Trial of FG-4592, a Novel Hypoxia Inducible Factor Prolyl Hydroxylase Inhibitor, in CKD Anemia, Vol. 2007, American Society of Nephrology Renal Week, San Francisco, November 2-5, 2007, Abstract SU-PO806, as abstracted in N. Agarwal and J. T. Prchal, Semin. Hematol., 2008, 45, 267. 

Taylor DN, MacKenzie R, Durbin A, Carpenter C, Atzinger CB, Haake R, Bourgeois AL Double-blind, placebo-controlled trial to evaluate the use of rifaximin (200 mg TID) to prevent diarrhea in volunteers challenged with Shigella Jlexneri 2a (2457T). Am J Trop Med Hyg 2004 71(suppl 4) 1-303 (abstract No. 2079). 

Cauley JA, Martino S, Barrett-Connor E et al. (2004) Effect of raloxifene on invasive breast cancer incidence in postmenopausal women stratified by Gail risk assessment results of the Continuing Outcomes Relevant to Evista (CORE) trial. Abstract 1018. American Society of Clinical Oncology... 

Purdie D, Cauley J, Disch D et al. (2004) Effect of raloxifene on incidence of invasive breast cancer in postmenopausal women having a history of prior hormone therapy use results of the CORE trial Abstract. European Society of Medical Oncology (ESMO), Vienna... 

Jordan VC, Glusman JE, Eckert S, Lippman M, Powles T, Costa A, et al. (1998) Incident primary breast cancer are reduced by raloxifen integrated data from multicenter, double-blind, randomized trial in 12,000 postmenopausal women. Proc Am Soc Clin Oncol 17 122a (abstract)... 

Abstract Metofluthrin (commercial name SumiOne, Eminence ) is a novel pyrethroid insecticide developed by Sumitomo Chemical Co., Ltd. Metofluthrin has extremely high insecticidal activity to various pest insects, especially to mosquitoes. In addition, Metofluthrin has relatively high volatility and low mammalian toxicity. Metofluthrin is therefore suitable for use not only in conventional mosquito control formulations such as coils and liquid vaporizers, but also in a variety of novel devices that do not require heating, such as fan vaporizers and paper and resin emanators. Here we describe the insecticidal activity of Metofluthrin mainly against mosquitoes in various formulations in both laboratory and field trials. 

The development of Cat K inhibitors, with an emphasis on the fundamental biology, pharmacology and human clinical trials has been recently reviewed [1-3]. The medicinal chemistry of Cat K inhibitors has also been the subject of recent reviews [7,8]. This article reviews recent publications and meeting abstracts on the design of Cat K inhibitors, as well as developments in Cat K-related biology including animal models for the prediction of inhibitor efficacy, the potential for the separation of bone resorption and formation by Cat K inhibitors, inhibitor selectivity considerations and other potential indications for Cat K inhibitors. 

Wierzbicki, T. and Wojcik, 0. Preliminary trials on the decomposition of acrolein, allyl alcohol, and glycerol by activated sludge, Zesz. Nauk. Polltech Slaska Inz. Sanit, 8 173-185 [Chemical Abstracts 68 1589z, 1968]. 

The concept of torsional asymmetry is not jnst an interesting abstract idea. Some years ago, fertility in some Chinese rnral commnnities was found to be below normal levels, and this was traced back to the presence of gossypol in dietary cottonseed oil. Gossypol acts as a male contraceptive, altering sperm matnration, spermatozoid motility, and inactivation of sperm enzymes necessary for fertilization. Extensive trials in China have shown the antifertility effect is reversible after stopping the treatment, and it has potential, therefore, as a contraceptive for men. 

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