Zonula occludens proteins

Nakamuta S, Endo H, Higashi Y, Kousaka A, Yamada H, Yano M, Kido H (2008) Human immunodeficiency virus type 1 gpl20-mediated disruption of tight junction proteins by induction of proteasome-mediated degradation of zonula occludens-1 and -2 in human brain microvascular endothelial cells. J Neurovirol 14 186-195... 

Alveolar epithelial cells (AECs) are connected with each other by various epithelial cell-cell contacts (i.e., tight junctions, adherens junctions and others). These contacts comprise several groups of proteins, such as occludin, zonula occludens (ZO-1, -2, -3), claudins, tricellulin, E-cadherin and intercellular adhesion molecule-1 (ICAM-1) [13-15], Their regulation and interplay, which has influence on epithelial barrier properties, however, is largely unknown to date. 

Fasano, A., et al. 1995. Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro. J Clin Invest 96 710. 

Bolton, S.J., D.C. Anthony, and V.H. Perry. 1998. Loss of tight junction proteins occluding and zonula-occludens-1 from cerebral vascular endothelium during neutrophil-induced blood-brain barrier breakdown in vivo. Neuroscience 86 1245. 

Figure 2.2. The intercellular junction is mediated by proteins at different levels (1) tight junction (zonula occludens), (2) adherens junction zonula adherens), and (3) desmosomes.

Kevil CG, Okayama N, Trocha SD, et al. Expression of zonula occludens and adherens junctional proteins in human venous and arterial endothelial cells role of occludin in endothelial solute barriers. Microcirculation 1998 5 197-210. 

Antonetti DA, Barber AJ, Hollinger LA, Wolpert EB, Gardner TW. Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors. J Biol Chem 1999 274 23,463-23,467. 

Phosphatase tensin on chromosome ten mutated in multiple advanced cancers Phosphatidyl inositol kinase cellular homolog AKT 8 mouse thymic retroviral oncogene PDZ postsynaptic density protein drosophila disc large tumor suppressor ZO zonula occludens... 

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