Phosphatidyl inositol-3,4-kinase

A similar study was conducted by Shoelson. Phosphatidyl inositol 3-kinase is activated by contact with autophosphorylated tyrosine kinase receptors followed by agonist binding to the cell-surface receptor. The truncated regulatory subunit of the enzyme (p85), which contains an SH2 domain, retained its full... 

Yao R, Cooper GM (1995) Requirement for phosphatidyl-inositol 3-kinase in the prevention of apoptosis by nerve growth factor. Science 267 2003-2006... 

Fig. 6.3. Formation of diacylglycerol, Ins(l,4,5)P3 and PtdIns(3,4,5)P3. PL-C phospholipase of type C PI3-kinase phosphatidyl inositol-3 -kinase.

Ge C, Anand-Srivastava MB. 1998. Involvement of phosphatidyl inositol-3-kinase and mitogen-activted protein kinase in All-mediated enhanced expression of Gi proteins in vascular smooth muscle cells. Biochem Biophys Res Commun 251 570-575. 

The GTP form of Ras protein specifically binds to the catalytic 110 kDa subunit of phosphatidyl inositol-3-kinase (PI3-kinase, see Section6.6). There is clear experimental evidence that PI3-kinase is downstream from the Ras protein and that its activity may be controlled by Ras protein. Activation of PI3-kinase leads to... 

Klocker N, Kermer P, Weishaupt JH, Labes M, Ankerhold R, Bahr M. Brain-derived neurotrophic factor-mediated neuroprotection of adult rat retinal ganglion cells in vivo does not exclusively depend on phosphatidyl-inositol-3 -kinase/protein kinase B signaling. J Neurosci 2000 20 6962-6967. 

Nomura M, Kaji A, He Z, Ma WY, Miyamoto K, Yang CS, Dong Z. Inhibitory mechanisms of tea polyphenols on the UVB-activated phosphatidyl-inositol 3-kinase dependent pathway. J Biol Chem 2001 276 46624-46631. 

Neudesin, a secreted protein with neurotrophic activity in primary cultured mouse neurons, but not with mitogenic activity in mouse astrocytes. The activity is mediated via the activation of mitogen-activated protein (MAP) and the phosphatidyl-inositol-3 kinase pathways. Besides mouse neudosin (171 aa), human neudosin with 172 aa ( 91% sequence identity) was also identified [I. Kimura et al., J. Neurosci. Res. 2005, 79, 287]. 

Akt includes phosphatidyl inositol 3 kinase (PI3K), protein kinase C alpha (33), (PKCa) (35), and E-cadherin, and B catenin to activate membrane proteins downstream (33, 36). 

PI3K Phosphatidyl inositol 3 kinase, an enzyme that phosphorylates phosphatidyl inositol. 

End, R, et al. (1993). A Biosensor Approach to Probe the Structure and Function of the P85a Subunit of the Phosphatidyl-inositol 3-kinase Complex, 7 Biol. Chem. 268 10066-10075. 

Turner SJ, Domin J, Waterfleld MD, Ward SG, Westwick J. The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/pll0 phosphatidyl-inositol 3-kinase and the class II P13K-C2alpha. J Biol Chem 1998 273 25987-25995. 

Shi Y, Yan H, Frost P, Gera J, Lichtenstein A. Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate 1/phosphatidyl-inositol 3-kinase cascade. Mol Cancer Ther 2005 4 1533-1540... 

Jain SK, Langdon WY, Varticovski L. Tyrosine phosphorylation of pl20cbl in BCR/abI transformed hematopoietic cells mediates enhanced association with phosphatidyl inositol 3-kinase. Oncogene. 1997 14 1127-2228. 

Carnero A, Lacal JC. 1998. Wortmarmin, an inhibitor of phosphatidyl-inositol 3-kinase, induces oocyte maturation through a MPF-MAPK-dependent pathway. FEES Lett 422(2) 155-159. 

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