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Tight junction modulating

Salama NN, Eddington ND, and Fasano A [2006] Tight junction modulation and its relationship to drug dehvery. Adv Drug Deliv Rev 58 15-28... [Pg.362]

Tight Junction Modulator Approximate Time Required to Deplete TER... [Pg.26]

Abstract This chapter attempts to give an overview on the properties of the intestinal epithelium with regard to both, barriers to transcellular (transporter and efflux systems) and paracellular (tight junctional complex) drug absorption and transport systems and tight junction modulation. A short introduction into the relation between the innate immune system and modulation of paracellular permeability is equally given. [Pg.49]

Deli, M.A. Potential use of tight junction modulators to reversibly open membranous bturi-ers and improve drug delivery. Biochim. Biophys. Acta 1788, 892 (2009)... [Pg.338]

Membrane and tight junction modulation Macrolides influence membrane properties, most likely via insertion and thereby function in both ion permeability and the interaction with membrane proteins. 27... [Pg.235]

Solvents used to increase solubility for compounds during screening of permeability across the cell monolayers, together with commonly used excipients for formulations, can also affect the barrier as they contain ingredients which enhance drug absorption [100, 151]. There are different mechanisms by which these compounds can modulate the barrier [4, 149, 150] for example, they may increase the tight junctional pathway inhibiting carrier-mediated transport, or cholesterol... [Pg.117]

In the past, changes in RTj were viewed in terms of assembly/disassembly of the tight junctional complex (reviewed in 93). Recent studies in human vaginal-cervical epithelia have shown acute and reversible modulation of Rtj that are the result of conformational changes in assembled tight junctions [13], The examples presented below relate to effects of modulation of extracellular calcium level (Ca0) and treatments with ATR... [Pg.346]

Zeng R, Li X, and Gorodeski GI [2004] Estrogen abrogates transcervical tight junctional resistance by acceleration of Occludin modulation. J Clin Endocrinol Metab 89 5145-5155... [Pg.359]

Zhu L, Li X, Zeng R, and Gorodeski GI [2006] Changes in tight junctional resistance of the cervical epithelium are associated with modulation of content and phosphorylation of occludin 65 kDa and 50 kDa forms. Endocrinology... [Pg.360]

Jovov B, Lewis SA, Crowe WE, Berg JR, and Wills NK [1994] Role of intracellular Ca2+ in modulation of tight junction resistance in A6 cells. Am J Physiol 266 F775-F784... [Pg.363]

Williams H, Neuhaus J, Kniesel U, KrauB B, Schmid E-M, Ocalan M, Farell C, Risau W (1980) Modulation of tight junction structure in blood-brain barrier endothelial cells. J Cell Sci 107 1347-1357... [Pg.415]

Fasano, A., and S. Uzzau. 1997. Modulation of intestinal tight junctions by zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model. J Clin Invest 99 1158. [Pg.51]

Ward, P.D., T.K. Tippin, and D.R. Thakker. 2000. Enhancing paracellular permeability by modulating epithelial tight junctions. Pharm Sci Technol Today 3 346. [Pg.52]

Fasano, A., et al. 1995. Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro. J Clin Invest 96 710. [Pg.52]

Wang, W., et al. 2000. Human zonulin, a potential modulator of intestinal tight junctions. J Cell Sci 113 4435. [Pg.52]

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See also in sourсe #XX -- [ Pg.223 ]



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