Zolmitriptan

CjHioOj 105-58-8) see Ambuside Bisoprolol Fenspiride Flurbiprofen Furazolidone Ketoprofen Mephenytoin Nifuratel Pheno barbital Pranoprofen Protizinic acid Temafloxacin Toloxatone Tybamate Zolmitriptan... 

S)-4-(4-hydrazinobenzyl)-2-oxazolidinone hydrochloride (C H,4C1N302 139264-57-6) see Zolmitriptan a-hydrazino-3,4-dimethoxy-a-methylbenzenepropane-nitrile... 

C,H, N204 949-99-5) see Melphalan Zolmitriptan 4-nitro-L-phenylalanine ethyl ester monohydrochloride (C, H 5C1N204 58816-66-3) see Melphalan... 

Direct attenuation of the excitability of neurons in the trigeminal nuclei, as 5-HTib/ 5-HTid receptors on pain transmission neurons in the trigeminal nucleus caudalis and in the upper cervical cord, are activated. Stimulation of these receptors is caused by second-generation triptans that cross the blood-brain barrier such as zolmitriptan, naratriptan, rizatriptan and eletriptan. 

Nasal spray Zolmitriptan 5, 10, or 20 mg at onset can repeat after 2 hours if needed Optimal dose is 20 mg maximum daily dose is 40 mg single-dose device delivering 5 or 20 mg administer one spray in one nostril... 

Sumatriptan, zolmitriptan, naratriptan, rizatriptan, almotriptan, fro-vatriptan, and eletriptan are appropriate first-line therapies for patients with moderate to severe migraine or as rescue therapy when nonspecific medications are ineffective. 

Antimigraines Sumatriptan, naratriptan, zolmitriptan, rizatriptan Vishwanathan et al. (2000)... 

Vishwanathan K, Bartlett MG, Stewart JT. 2000. Determination of antimigraine compounds rizatriptan, zolmitriptan, naratriptan and sumatriptan in human serum by liquid chromatography/electrospray tandem mass spectrometry. Rapid Commun Mass Spectrom 14 168. 

Pethidine and morphine, used as opioid analgesics, may cause dependence following repeated administration. Zolmitriptan, a 5HT, agonist used in the treatment of acute migraine attacks, is not associated with dependence. 

Administered orally, ergotamine and sumatriptan, eletriptan, naratrip-tan, rizatriptan, and zolmitriptan have only limited bioavailability. Dihydroer-gotamine may be given by i.m. or slow i.v. injection, sumatriptan subcutaneously or by nasal spray. 

Not intended for the prophylactic therapy of migraine or for use in the management of hemiplegic or basilar migraine. Safety and efficacy have not been established for cluster headache, which is present in an older, predominantly male population (almotriptan, eletriptan, frovatriptan, sumatriptan tablets and spray, zolmitriptan). 

ZOLMITRIPTAN Initial recommended dose is up to 2.5 mg (achieved by manually breaking a 2.5 mg tablet in half). If the headache returns, the dose may be repeated after 2 hours, not to exceed 10 mg within a 24-hour period. Response is greater following the 2.5 or 5 mg dose compared with 1.25 mg, with little added benefit and increased side effects associated with the 5 mg dose. 

Nasal spray - Administer 1 dose of 5 mg for the treatment of acute migraine. If the headache returns, the dose may be repeated after 2 hours. Do not exceed a maximum daily dose of 10 mg in any 24-hour period. Individuals may vary in response to zolmitriptan. The pharmacokinetics of a 5 mg nasal spray dose is similar to the 5 mg oral formulations. Doses lower than 5 mg can only be achieved through the use of an oral formulation. Therefore, choose the dose and route of administration on an individual basis. The efficacy of a second dose has not been established in placebo-controlled trials. 

Hepatic function impairment- Administer zolmitriptan with caution in patients with liver disease, generally using doses less than 2.5 mg. Patients with moderate to severe hepatic impairment have decreased clearance of zolmitriptan significant elevation in blood pressure was observed in some patients. 

Pharmacology Naratriptan, rizatriptan, sumatriptan, frovatriptan, almotriptan, eletriptan, and zolmitriptan are selective agonists for a vascular 5-hydroxytryptamine-i(serotonin) receptor subtype. Use of 5-HT- agonists results in... 

Zolmitriptan- Patients with symptomatic Wolff-Parkinson-White syndrome or arrhythmias associated with other cardiac accessory conduction pathway disorders should not receive zolmitriptan. 

Lactation Sumatriptan and eletriptan are excreted in breast milk. Zolmitriptan, naratriptan, almotriptan, frovatriptan, and rizatriptan are excreted in rat milk. Children Safety and efficacy in children have not been established. 5-HT- receptor... 

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