Zolmitriptan Quinolones

ZOLMITRIPTAN QUINOLONES Possible 1 plasma concentrations of zolmitriptan, with risk of inadequate therapeutic efficacy Possibly induced metabolism of zolmitriptan Be aware of possibility of 1 response to triptan, and consider t of dose if considered to be due to interaction. 

The UK manufacturer recommends a dose reduction of zolmitriptan to a maximum of S mg in 24 hours in patients taking quinolone antibacterials such as ciprofloxacin. This is because these antibacterials are predicted to increase levels of zolmitriptan by inhibiting the cytochrome P450 isoenzyme CYP1A2, an enzyme involved in the metabolism of zolmitriptan. This is based on the known interaction with cimetidine , (above). However, the US manufacturer makes no comment on this theoretical interaction. ... 

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See also in sourсe #XX -- [ ]

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