Zolmitriptan Citalopram

Clinically important, potentially hazardous interactions with amitriptyline, amoxapine, bupropion, citalopram, clomipramine, desipramine, doxepin, fluoxetine, fluvoxamine, imipramine, meperidine, nefazodone, nortriptyline, paroxetine, pizotifen, protriptyline, rizatriptan, sertraline, sibutramine, sumatriptan, trimipramine, tryptophan, venlafaxine, zolmitriptan... 

A two-period crossover, double-blind study in 20 subjects given fluoxetine 20 mg or a placebo daily for 28 days, with zolmitriptan 10 mg on day 28, found that the pharmacokinetics of zolmitriptan were unaffected by fluoxetine. Only very slight changes were seen in the pharmacokinetics of its active metabolite. Sertraline, paroxetine, and citalopram are also not expected to alter the pharmacokinetics of zolmitriptan. However, fluvoxamine, a CYP1A2 inhibitor, is predicted to increase levels of zolmitriptan, based on the known interaction with cimetidine (see Triptans Zolmitriptan + Cimetidine , p.608). 

A 48-year-old woman who had taken zolmitriptan 5 mg/day for migraine for 5 years developed Prinzmetal-variant angina 2 weeks after starting to take citalopram 20 mg/day for newly diagnosed depression. 

Acikel S, Dogan M, Sari M, Kilic H, Akdemir R. Prinzmetal-variant angina in a patient using zolmitriptan and citalopram. Am J Emerg Med 2010 28(2) 257.e3-6. 

---