Z-resveratrol

Z)-resveratrol 3,5-0-y8-diglucoside Vitis vinifera cell cultures 24... 

Many natural stilbene glycosides have also been reported to have significant antioxidant activities, for example, (Z)-astringin and ( )-and (Z)-resveratrol-4 -0-6-D-glucopyranoside [478], astringin [479], 2,3,4, 5-tetrahydroxy stilbene-2-0-6-D-glucopyranoside [20], compounds 51 [28], 53 [11], 61 and 62 [500]. 

Huang C, Ma WY, Goranson A, Dong Z. Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway. Carcinogenesis 1999 20 237-242. 

Of the 18 stilbenoids identified in various wines, 13 have been quantified. These molecules include E- and Z-resveratrol, E- and Z-piceid, E- and Z-piceatannol, and E- and Z-astringin, hopeaphenol, pallidol, parthenocissin A, - -viniferin, and -5-viniferm. 

Basly JP, Mane-Foumier F, Le Bail JC, Habrioux G, Chulia AJ (2000) Estrogenic/ antiestrogenic and scavenging properties of (E)- and (Z)-resveratrol. Life Sci 66 769-777... 

She QB, Bode AM, Ma WY, Chen NY, Dong Z. Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase. Cancer Res 2001 61 1604-1610. 

Huang H, Zhang J, Chen G, Lu Z, Wang X, Sha N, Shao B, Li P, Guo DA. 2008. High performance liquid chromatographic method for the determination and pharmacokinetic studies of oxyresveratrol and resveratrol in rat plasma after oral administration of Smilax china extract. Biomed Chromatogr 22 421-427. 

Murias M, Jager W, Handler N, Erker T, Horvath Z, Szekeres T, Nohl H, Gille L. 2005. Antioxidant, prooxidant and cytotoxic activity of hydroxylated resveratrol analogues Structure-activity relationship, Biochem Pharmacol 69 903-912. 

Estrov Z, Shishodia S, Faderl S, Harris D, Van Q, Kantarjian HM, Talpaz M, Aggarwal BB. 2003. Resveratrol blocks interleukin-1 beta-induced activation of the nuclear transcription factor NF-kB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells. Blood 102 987-995. 

Hsieh TC, Lu X, Wang Z, Wu JM. 2006. Induction of quinone reductase NQOl by resveratrol in human K562 cells involves the antioxidant response element ARE and is accompanied by nuclear translocation of transcription factor Nrf2. Med Chem 2 275-285. 

She QB, Ma WY, Wang M, Kaji A, Ho CT, Dong Z. 2003. Inhibition of cell transformation by resveratrol and its derivatives Differential effects and mechanisms involved. Oncogene 22 2143-2150. 

She QB, Huang C, Zhang Y, Dong Z. 2002. Involvement of c-jun NH(2)-terminal kinases in resveratrol-induced activation of p53 and apoptosis. Mol Carcinog 33 244—250. 

Yu H, Pan C, Zhao S, Wang Z, Zhang H, Wu W. 2008. Resveratrol inhibits tumor necrosis factor-alpha-mediated matrix metalloproteinase-9 expression and invasion of human hepatocellular carcinoma cells. Biomed Pharmacother. 62 366-372. 

Regev-Shoshani G, Shoseyov O, Bilkis I, Kerem Z. 2003. Glycosylation of resveratrol protects it from enzymic oxidation. Biochem J 374 157-163. 

Zhang Y, Li S-Z, Pan X, Cahoon RE, Jaworski JG, Wang X, Jez JM, Chen F, Yu O. 2006. Using unnatural protein fusion to engineer resveratrol biosynthesis in yeast and mammalian cells. J Am Chem Soc 128 13030-13031. 

Xia, L., Wang, X.X., Hu, X.S., Guo, X.G., Shang, Y.P., Chen, H.J., Zeng, C.L., Zhang, F.R., Chen, J.Z. (2008). Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms. Br. J. Pharmacol. June 30. (Epub ahead of print)... 

Hsieh, T.C., Juan, G.L., Darzynkiewicz, Z., and Wu, J.M., Resveratrol increases nitric oxide synthase, induces accumulation of p53 and p21 wafi/cipi suppresses cultured bovine pulmonary artery endothelial cell proliferation by perturbing progression through S and Gj, Cancer Res., 59, 2596, 1999. 

Mattivi, R, Solid phase extraction of trans-resveratrol from wines for HPLC analysis, Z. Lebensm. Unters. Forsch., 196, 522, 1993. 

Resveratrol (1) could be biotransformed by Botrytis cinerea (a fungal grapevine pathogen) into resveratrol ( )-dehydrodimer (553), resveratrol (Z)-dehydrodimer (556), pallidol, leachianol F (515), and restrytisols A-C (547-549) [249,250]. It has been proved that intestinal bacteria in animals could reductively metabolize stilbene oxide to the corresponding alkenes [380]. 

Wang J, Santa-Maria I, Ho L, Ksiezak-Reding H, Ono K, Teplow DB et al (2010) Grape derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer s disease. J Alzheimers Dis 22 653-661. Zhao YN, Li WF, Li F, Zhang Z, Dai YD, Xu AL et al (2013) Resveratrol improves learning... 

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