Wound contraction

When collagen-GAG matrices which can significantly delay the onset of wound contraction are seeded with a minimum density of easily separable skin cells (basal cells) from the same animal, and the cell-seeded matrices are then grafted, wound healing is affected in an even more profound way In this case,... 

Fig. 12. The kinetics of contraction of full-thickness guinea pig skin wounds separate collagen-GAG matrices into three classes. The wound half-life t,/2 is the number of days necessary to reduce the original wound area to 50%. An inactive matrix does not delay wound contraction significantly relative to the ungrafted control and eventually allows formation of a linear scar. An active, cell-free matrix delays wound contraction by about 20 days but eventually allows lull contraction to occur. An active matrix, which has been seeded with a minimal number of skin cells, delays contraction significantly, later arrests it, and eventually induces synthesis of a new dermis and epidermis within an expanding wound perimeter...

Table 3 Course of wound contraction with respect to the wound area at day 0 using different dressing materials for induction of the wound healing in sheep [150]...

Skin wound healing was investigated in a riboflavin-deficient rat model epithelialization was prolonged, wound contraction slowed and total collagen content reduced by 25%.114... 

Aberrant Collagen Production (TVpes VI, VIII) Wound Contraction... 

Significant delay in onset of wound contraction occurred with wounds grafted with Stage 1 membranes compared to the ungrafted controls. We observed a delay in half-life of the 3 X 1.5-cm wound (the time necessary for the wound area to contract to 50% of the original area) from about 13 days with the ungrafted controls to about 28 days with grafted wounds. 

Shafritz TA, Rosenberg LC, Yannas IV. Specific effects of glycosaminogly-cans in an analog of extracellular matrix that delays wound contraction and induces regeneration. Wound Repair Regen 1994 2 270-276. 

H.M. Powell, D.M. Supp, S.T. Boyce, Influence of electrospun collagen on wound contraction of engineered skin substitutes, Biomaterials 29 (2008) 834-843. 

S.T. Boyce, M.C. Glafkides, T.J. Foreman, J.F. Hansbrough, Reduced wound contraction after grafting of full-thickness burns with a collagen and chondroitin-6-sulfate (GAG) dermal skin substitute and coverage with biobrane, J. Burn Care Res. 9 (4) (1988) 364-370. 

Ishihara, M., K. Ono, F. Sato, K. Nakanishi, I. Saito, H. Yura, T. Matsui, H. Hattori, M. Fujita, M. Kikuchi, and A. Kurita. 2001. Acceleration of wound contraction and healing with a photocrosshnkable chitosan hydrogel. Wound Repair and Regeneration 9 (6) 513-521. 

When fibroblasts are cultured in three-dimensional collagen gels, fibroblasts contract the gels. This phenomenon has been considered to be an in vitro model of wound contraction and connective... 

Mean wound area assessment of the treatment groups showed that immediate skin graft alone contracted less (7.12% surface area contraction) than both the immediate and the delayed graft over polymer treatment groups (21.63% and 37.57%, respectively). Examination of the curve over time suggests that for the delayed group, wound contraction appreciably stopped on application of the skin graft. 

To address this issue of wound contraction, a 30-nm-thick biodegradable, nucroporous polyurethane membrane was bonded to the superficial surface of a new 2 mm-thick foam matrix. This was intended to seal the foam, acting as a barrier to the development of linear collagen fibers on the surface before application of the skin graft, which... 

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