Wisconsin Alumni Research Foundation

Further work in this area showed that only one of the cou-marin rings was needed for biologic activity. Condensation of the hydroxyacetophenone, 4, with diethyl carbonate affords 4-hydroxycoumarin (2). The reaction may involve the 3-ketoester (5) cyclization of this would afford 2. Alternately, the reagent may first give the 0-acyl derivative cyclization as above will give the same product. Michael condensation of the coumarin with benzalacetone (6) affords the anticoagulant warfarin (named after its place of origin Wisconsin Alumni Research Foundation,... 

Ishikawa, M., Kaneko, C., Suda,T., Yamada, S., Eguchl, Y.,Sugimoto, A, and Saseki, S. U.S. Patent 3,929,770 December 30,1975 assigned to Wisconsin Alumni Research Foundation. 

Stahmann, M.A., Ikawa, M. and Link, K.P. U.S. Patent 2,427,578 September 16, 1947 assigned to Wisconsin Alumni Research Foundation Schroeder, C.H. and Link, K.P. U.S. Patent 2,765,321 October 2, 1956 assigned to Wisconsin Alumni Research Foundation... 

Link, K.P. U.S. Patent 2,777,859 January 15, 1957 assigned to Wisconsin Alumni Research Foundation... 

Received October 8, 1962. Work supported by the National Science Foundation and the Wisconsin Alumni Research Foundation. 

DeLuca H.F., Schnoes H.K. US Patent No. 3,907,843 Sept. 23, 1975 Assigned to Wisconsin Alumni Research Foundation, Madison, Wis. 

I wish to express at this time my appreciation for the substantial support which I have received for my research program from the Wisconsin Alumni Research Foundation and from Charles S. Slichter, Dean Emeritus of the Graduate School of the University of Wisconsin. 

This work was supported in part by a program project grant (no. DK14881) from the National Institutes of Health, a fund from the National Foundation for Cancer Research, and a fund from the Wisconsin Alumni Research Foundation. 

Chemicals that control rats are termed rodenticides. The first effective compound was warfarin. It was developed by the Wisconsin Alumni Research Foundation in 1944. It functions as an anticoagulant in human medicine. However, when used against rats and mice, at high concentrations it is extremely effective, causing death by internal hemorrhaging. 

The coumarins were first discovered in Wisconsin, when bleeding in cattle was found to be due to the consumption of bruised sweet clover in the 1920s (1). The causative agent, dicoumarol, was isolated in 1940, and a range of related compounds was then synthesized, the most popnlar of which proved to be warfarin (named after the Wisconsin Alumni Research Foundation). Other conmarins that have been used are acenocoumarol (nicoumalone), bishydroxycoumarin, dicoumarol, ethyl biscoumacetate, and phenproconmon. 

Propylene glycol (1,2-propanediol) is a commodity chemical. U.S. 6,087,140 (to Wisconsin Alumni Research Foundation) describes a process for fermentation of sugars to propylene glycol using transformed microorganisms. Estimate the maximum price that could be charged for the microorganisms. 

In 1921, during a particularly wet year a large number of cattle died from a hemorrhagic disorder. Investigation by the Wisconsin Alumni Research Foundation (WARF) eventually identified the cause of the disorder in a substance found in the rotting sweet clover used as feed by the cattle. The name warfarin is a combination of the acronym for the original patent holder (WARF) and the suffix from coumarin. 

Cell lines-. HEK 293 stably expressing HERG K+ (University of Wisconsin Alumni Research Foundation, Madison, WI, USA). 

Karl Paul Link [1] from the University of Wisconsin investigated the compounds in spoiled sweet clover, trying to elucidate the causes of hemorrhage in cattle after ingestion. The offending compound isolated in his laboratory was named dicoumarol and used in medical care as an anticoagulant for many years. Subsequent to their synthesis of dicoumarol, scientists in Link s laboratory synthesized many similar compounds, including one believed too toxic to use. Mark Stahmann, with the help of the Wisconsin Alumni Research Foundation (WARF), patented the compound that would later be named warfarin (US Patent 2,427,578) [1]. 

Preparation of (S)-ibuprofen by enzyme-catalyzed enantioselective hydrolysis of racemic ibuprofen esters has been investigated by several companies such as Sepracor [50,51], Rhone-Poulenc [52,53], Gist-Brocades [54,55], and the Wisconsin Alumni Research Foundation [56]. These processes are usually performed under mild reaction conditions, yield highly optically pure product, and can be readily scaled up for industrial production. The disadvantage of these processes for (S)-ibuprofen production is the extra step needed to produce the corresponding ester of racemic ibuprofen, as well as the cost of producing the enzyme and microorganism catalysts. 

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