Walter Reed Army Institute of Research

T. R. Sweeney, M Survey of Compoundsfrom the Hntiradiation Drug Development Program of the U.S. Army Medical Research and Development Command Walter Reed Army Institute of Research, Washington, D.C., 1979. 

Dr. David Mackenzie Rioch, a stem-faced, fundamentally benign man with dark bushy eyebrows, seemingly sensed that I might have been cast from a different mold. He was a relentlessly dedicated scientist who supervised my efforts at outpatient therapy for an hour each week. As civilian Chief of the Neuropsychiatry Division of the nearby Walter Reed Army Institute of Research (WRAIR), Rioch had a prestigious and well-earned international reputation. 

In 1969, we recommended long-term reevaluation of our subjects. But it wasn t until 1980 that LTC David McFarling at the Walter Reed Army Institute of Research (WRAIR) published a comprehensive follow-up of Edgewood volunteers who had received LSD. The results, discussed in detail later in this book, failed to demonstrate any clear-cut, long-term adverse medical or psychiatric effects. 

The Army didn t act to shield itself from further criticism until the mid-1970s, when Congress began to feel increasing pressure from critics. Only then, did its members request a systematic search for possible after effects in former LSD volunteers. Lieutenant Colonel David A. McFarling, MD, a psychiatrist assigned to the Walter Reed Army Institute of Research (WRAIR) in DC, accepted the task. He designed a comprehensive follow-up study of all volunteers who had received LSD under Chemical Corps auspices. In October 1980, the US Army Medical Department, US Army Health Services Command, published his report. 

As my time at Stanford was approaching an end, my old boss Joe Blair at Edgewood and my mentor David Rioch at the Walter Reed Army Institute of Research (WRAIR) simultaneously requested my assignment to their installations. Both apparently believed (incorrectly) that my competence had somehow been enhanced by my 24-month sojourn in the magic halls of academe. 

Information provided by the Walter Reed Army Institute of Research, Walter Reed Army Medical Center, U.S. Department of the Army... 

The Walter Reed Army Institute of Research s Department of Behavioral Biology has developed a field-deployable version of a commercial Psychomotor Vigilance Task (PVT) that has been widely used in sleep research. The software runs on handheld PDAs running the Palm Operating System (Palm OS). It is modeled after the simple reaction time task of Wilkinson and Houghton,57 as modified by Dinges and Powell.58 The Palm OS version incorporates additional stimulus, feedback, control, and data options developed by Dr. Thome. In laboratory studies, performance on the PDA task has been shown to be sensitive to time-on-task fatigue effects, sleep deprivation, and circadian variation.18 Field studies have utilized the PVT to measure the efficacy of caffeine gum as a sleep loss countermeasure. 

Walter Reed Army Institute of Research, Silver Spring, Maryland, U.S.A. Selim R. Benbadis... 

We would like to thank Drs. Robert Engle, Jean Karle, Dennis Kyle, Wil Milhous and Robert Miller of the Walter Reed Army Institute of Research for their advice and collaborations in preceding years, members of the Medicinal Chemistry Department (University of Mississippi), and Dr. James D. McChesney (NaPro Biotherapeutics). Support of this work was funded by the Department of Defense USAAMRDC (WRAIR), UNDPAVorld Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), NIAID, and the University of Mississippi Research Institute of Pharmaceutical Sciences. 

C. Canfield, Biol. Systems, Inc., Gaithersburg, Maryland 20879, personal communication on compounds tested at the Walter Reed Army Institute of Research in Washington, D.C. 

Jensen, P., Bain, M., 6c Josephson, A. (n.d. circa 1989). Why Johnny can t sit still Kids ideas on why they take stimulants. Unpublished manuscript, Division of Neuropsychiatry, Walter Reed Army Institute of Research, Washington, DC. 

The test system used by the Walter Reed Army Institute of Research for screening compounds against leishmania infections in golden hamsters has been described, and data were presented on a variety of 6,and 3-aminoqulnollnes. The most active analog, 6, was more than TOO times as active as the meglumine antlmoniate (Glucanttme ) standard. 

To test for in vivo antiplasmodial activities of the methanol extracts, the mouse-infective, the CQ-susceptible (D6) and resistant (W2) clones donated by the Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington DC, were used. To test the in vitro antiplasmodial activities of the plant extracts, the CQ-sensitive P. berghei (strain ANKA), donated by International Livestock Research Institute (ILRI), Kenya was used. 

Therapeutics Program Total U.S. Army (DOD) Walter Reed Army Institute of Research 1963 1,900 389,609... 

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