Walter Reed

T. R. Sweeney, M Survey of Compoundsfrom the Hntiradiation Drug Development Program of the U.S. Army Medical Research and Development Command Walter Reed Army Institute of Research, Washington, D.C., 1979. 

Walter Reed-Wistar and Charles River male adult rats were exposed to oral doses of turpentine or to turpentine vapors, which consisted of a- and p-pinene. These exposures were followed by oral administration of heptachlor epoxide or of one of three pesticides, paraoxon, heptachlor, or parathion, or by an intraperitoneal injection of hexobarbital. The studies revealed that pretreatment with turpentine reduced hexobarbital sleeping time, reduced the parathion LDso, and increased the heptachlor LDso. The paraoxon and heptachlor epoxide LOo values were unchanged. a-Pinene and P-pinene vaporized from turpentine had no effect on either hexobarbital sleeping time or parathion, paraoxon, or heptachlor epoxide mortality but did increase the heptachlor LDso (Sperling et al. 1972). The authors speculated that increases in hepatic microsomal enzyme activity are responsible for these differences. 

Texas, learning to be a proper Regular Army Officer followed thereafter by a hoped-for transfer to Walter Reed Army Hospital in Washington,... 

Dr. David Mackenzie Rioch, a stem-faced, fundamentally benign man with dark bushy eyebrows, seemingly sensed that I might have been cast from a different mold. He was a relentlessly dedicated scientist who supervised my efforts at outpatient therapy for an hour each week. As civilian Chief of the Neuropsychiatry Division of the nearby Walter Reed Army Institute of Research (WRAIR), Rioch had a prestigious and well-earned international reputation. 

Colonel Roy Clausen, M.D. Chief of Psychiatry at Walter Reed Army Hospital during my residency (1958). 

My apartment on Georgia Avenue during residency - 3 blocks from Walter Reed Army Hospital (1959)... 

In 1969, we recommended long-term reevaluation of our subjects. But it wasn t until 1980 that LTC David McFarling at the Walter Reed Army Institute of Research (WRAIR) published a comprehensive follow-up of Edgewood volunteers who had received LSD. The results, discussed in detail later in this book, failed to demonstrate any clear-cut, long-term adverse medical or psychiatric effects. 

The Army didn t act to shield itself from further criticism until the mid-1970s, when Congress began to feel increasing pressure from critics. Only then, did its members request a systematic search for possible after effects in former LSD volunteers. Lieutenant Colonel David A. McFarling, MD, a psychiatrist assigned to the Walter Reed Army Institute of Research (WRAIR) in DC, accepted the task. He designed a comprehensive follow-up study of all volunteers who had received LSD under Chemical Corps auspices. In October 1980, the US Army Medical Department, US Army Health Services Command, published his report. 

T s accident occurred before we had fully established the effectiveness of physostigmine as an antidote, but we did have tetrahydroaminoacridine (TELA) and used it over several days to minimize his delirious behavior. We housed him in our newly constmcted padded ward, and watched him closely for two weeks as he gradually returned to an ostensibly normal mental state. I discussed the problem with Dr. Rioch at Walter Reed, who advised me to provide supportive counseling for as long as necessary to ensure full recovery. 

Okay, I said. It looks like maybe you should be in the hospital for a bit, until things get sorted out. I picked up the phone, called one of the Walter Reed residents, told him I was sending him a patient for evaluation, and advised the delighted MP s to whisk the recalcitrant trooper to the hospital. 

As my time at Stanford was approaching an end, my old boss Joe Blair at Edgewood and my mentor David Rioch at the Walter Reed Army Institute of Research (WRAIR) simultaneously requested my assignment to their installations. Both apparently believed (incorrectly) that my competence had somehow been enhanced by my 24-month sojourn in the magic halls of academe. 

James S. Ketchum, M.D. is a Board Certified psychiatrist and Assistant Clinical Professor at UCLA, who received his education at Dartmouth and Columbia colleges, Cornell Medical School, Letterman and Walter Reed Hospitals, and Stanford University. 

Meanwhile, the wee bit of private practice I had engaged in, starting in late 1969, rekindled my interest in patient care. While cramming for Board exams, I immersed myself in clinical re-education. This fired me up even further. I began to recall my residency in psychiatry at Walter Reed Hospital with great fondness and remembered the satisfaction I had felt when patients under my care showed signs of recovery from a psychotic episode. 

Information provided by the Walter Reed Army Institute of Research, Walter Reed Army Medical Center, U.S. Department of the Army... 

A second subject (6849) experienced a grand mal seizure 3 h after receiving 300 mg of 2-PAM (chloride form) intramuscularly. He regained consciousness within 5 min he had bitten his tongue. He was initially lethargic, but felt well 10 h later. He was transferred to Walter Reed Hospital, but followup records are not available. He had received 300 mg of 2-PAM intramuscularly 5 and 8 d before the episode. The only symptom on those occasions was local pain at the injection site. 

Submitted by JAMES E. HUTCHISON, EVAN W. FOSTER, MARVIN G. WARNER, SCOTT M. REED, and WALTER W. WEARE Checked by WILLIAM BUHRO and HENG YU ... 

Walter Reed Army Institute Performance Assessment Battery... 

The Walter Reed Army Institute of Research s Department of Behavioral Biology has developed a field-deployable version of a commercial Psychomotor Vigilance Task (PVT) that has been widely used in sleep research. The software runs on handheld PDAs running the Palm Operating System (Palm OS). It is modeled after the simple reaction time task of Wilkinson and Houghton,57 as modified by Dinges and Powell.58 The Palm OS version incorporates additional stimulus, feedback, control, and data options developed by Dr. Thome. In laboratory studies, performance on the PDA task has been shown to be sensitive to time-on-task fatigue effects, sleep deprivation, and circadian variation.18 Field studies have utilized the PVT to measure the efficacy of caffeine gum as a sleep loss countermeasure. 

Thome, D.R. et al., The Walter Reed Palm-held Psychomotor Vigilance Test, Sleep, 26(Suppl.), 182,... 

Thome, D. et al., The Walter Reed Performance Assessment Battery, Neurobehav. Toxicol. Teratol., 7, 415, 1985. 

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