Vitamin receptor gene

Osteoporosis Commonly postmenopausal or In other cases Is more gradual and related to age a small number of cases are due to mutations In the COL lA 1 and COL 1A2 genes and possibly In the vitamin D receptor gene (MIM 166710)... 

Zmuda JM, Cauley JA, Ferrell RE. Molecular epidemiology of vitamin D receptor gene variants. Epidemiol Rev 2000 22 203-217. 

Saint J. Van Tomout JM, Loro ML, Sayre J, Roe TF, Gilsanz V. Vitamin D-receptor gene polymorphisms and bone density in prepubertal American girls of Mexican descent. New England Journal of Medicine 1997 337 7782. 

Hormones and vitamins also play a role in regulation of ASBT. Both glucocorticoid receptor ligands and co-expression of the glucocorticoid receptor gene increased activity of ASBT, while there is also evidence that dihydroxy vitamin D binds directly to the vitamin D response element and increases expression of ASBT, leading to increased transport of bile acids into the enterocyte. ... 

Ames, S., Ellis, K., Gurm, S., Copeland, K., and Abrams, S. (1999). Vitamin D receptor gene Fokl polymorphism predicts calcium absorption and bone mineral density in children. JBMR 14, 740-746. 

Canaff, L and Hendy, GN, 2002, Human calcium-sensing receptor gene. Vitamin D response elements in promoters PI and P2 confer transcriptional responsiveness to 1,25-dihydroxyvitamin D, J Biol Chem 277 30337-30350... 

Vitamin D receptor gene localized to chromosome 12ql2-q22 (see 1999) 35... 

Vitamin D receptor gene genomic structure determined 43... 

Hughes MR, Malloy PJ, Kieback DG, Kesterson RA, Pike JW, Feldman D, O Malley BW. Point mutations in the human vitamin D receptor gene associated with hypocalcemic rickets. Science 1988 242(4886) 1702-1705. 

In the context of dmg delivery, certain cell surface receptor and ion-channel families are particularly appealing as dmg delivery targets. Well-characterized examples include the lectin-like receptor gene family as receptors for glycosylated molecules, as well as vitamin- and trace element-uptake systems such as the transferrin-receptor. 

R. A. and Matthews, B.W., Type II restriction endonucleases structural, functional, and evolutionary relationships, Curr. Opin. Chem. Biol. 3, 578-583, 1999 Akar, A., Orkunoglu, F.E., Ozata, M., Sengul, A., and Gur, A.R., Lack of association between vitamin D receptor Fokl polymorphism and alopecia areata, Eur. J. Dermatol. 14, 156-158, 2004 Guy, M., Lowe, L.C., Bretherton-Watt, D. et al., Vitamin D receptor gene polymorphisms and breast cancer risk, Clin. Cancer Res. 10, 5472-5481, 2004 Claassen, M., Nouwen, J., Fang, Y. et al., Staphylococcus aureus nasal carriage is not associated with known polymorphism in the Vitamin D receptor gene, FEMS Immunol. Med. Microbiol. 43,173-176, 2005 Bolu,... 

J. Guardiola, X. Xiol, R. Sallie, et al. Influence of the vitamin D receptor gene polymorphism on bone loss in men after liver transplantation. Annals of Internal Medicine 131,752 (1999). 

Uitterlinden AG, Fang Y, Bergink AP, et al. The role of vitamin D receptor gene polymorphisms in bone biology. Mol Cell Endocrinol 2002 197 15-21. 

Poggi M, Aterini S, Nicastro L, et al. 1999. Lack of association between body weight, bone mineral density and vitamin D receptor gene polymorphism in normal and osteoporotic women. Disease Markers 15(4) 221-227. 

Yamamoto, H., Miyamoto, K., Li, B., Taketani, Y., Kitano, M., Inoue, Y., Morita, K., Pike, J.W., Takeda, E. 1999. The caudal-related homeodomain protein Cdx-2 regulates vitamin D receptor gene expression in the small intestine. J. Bone Min. Res. 14, 240-247. 

E. Bajna, S. Kriwanek el al. (2001). 25-Hydroxyvitamin Dj-la-hydroxylase and vitamin D receptor gene expression in human colonic mucosa is elevated during early cancerogenesis. Steroids 66, 287-292. 

Amyotrophic lateral sclerosis, lead, and genetic susceptibility polymorphism in in test delta-aminolevulinic acid dehydratase and vitamin D receptor genes. Environ. Health Perspect. 2003 111 1335-9. 

N, Aladag, D, Ozkan-Ariksoysal, D, Gezen-Ak, S, Yilmazer, and M, Ozsoz, An electrochemical DNA biosensor for the detection of the Apa I polymorphism in the vitamin D receptor gene using Meldola s blue as a hybridization indicator. Electroanalysis 22(5), 590-598 (2010),... 

Kamel, F., D.M. Umbach, T.A. Lehman, L.P. Park, T.L. Munsat, J.M. Shefner, D.P. Sandler, H. Hu, and J.A. Taylor. 2003. Amyotrophic lateral sclerosis, lead and genetic susceptibility Polymorphisms in the delta-aminolevulinic acid dehydratase and vitamin D receptor genes. Environ. Health Perspect. 111(10) 1335-1339. 

Aihara, K., Azuma, H., Akaike, M., et al. 2004. Disruption of nuclear vitamin D receptor gene causes enhanced thrombogenicity in mice. J Biol Chem, 279 35798-802. 

Maestro, B., Davila, N., Carranza, M. C., Calle, C. 2003. Identification of a vitamin D response element in the human insulin receptor gene promoter. J Steroid Biochem Mol Biol, 84 223-30. 

Crofts LA, Hancock MS, Morrison NA, Eismann JA (1998) Multiple promoters direct the tissue-specific expression of novel N-terminal variant human vitamin D receptor gene transcripts. Proc Natl Acad Sci USA 95 10529... 

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