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Receptor calcium-sensing

Calcium receptor Extracellular calcium-sensing receptor (CaSR)... [Pg.300]

Tfelt-Hansen J, Brown EM (2005) The calcium-sensing receptor in normal physiology and pathophysiology a review. Crit Rev Clin Lab Sci 42(1 ) 3 5-70... [Pg.305]

Extracellular Calcium-sensing Receptor (CaSR) Extracellular Matrix (ECM)... [Pg.1492]

Cinacalcet reduces PTH secretion by increasing the sensitivity of the calcium-sensing receptor. The most common adverse events are nausea and vomiting. [Pg.883]

The mGluRs belong to family C of the GPCR superfamily, which also includes a calcium-sensing receptor (CaR), two y-aminobutyric acid type B (GABAb) receptors,... [Pg.47]

Pace, A. J., Gama, L and Breitwieser, G. E. (1999) Dimerization of the calcium-sensing receptor occurs within the extracellular domain and is eliminated by Cys— Ser mutations at Cys101 and Cys236. J. Biol. Chem. 274,11629-11634. [Pg.75]

Brauner-Osbome, H., Jensen, A. A., Sheppard, P. O., O Hara, P., and Krogsgaard-Larsen, P. (1999) The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain. J. Biol. Chem. 274,18382-18386. [Pg.76]

Zhang, Z., Sun, S., Quinn, S. J., Brown, E. M., and Bai, M. (2001) The extracellular calcium-sensing receptor dimerizes through multiple types of intermolecular interactions../. [Pg.77]

Jensen, A. A., Spalding, T. A., Burstein, E. S., et al. (2000) Functional importance of the Ala116-Pro136 region in the calcium-sensing receptor constitutive activity and inverse ago-nism in a family C G protein coupled receptor../. Biol. Chem. 275,29547-29555. [Pg.77]

Calcium-Sensing Receptor Mutations and Hypercalcemia/ Hypocalcemia... [Pg.116]

Fig. 7.1 Localization of some mutations and polymorphisms reported for the calcium-sensing receptor (CASK). The relationship between the CASK gene exons (II to Vll) and the modular domains of the 1078-amino acid protein are indicated. The 610-amino acid exctracellular domain (BCD) is encoded by exons II to VI. The beginning of exon VII encodes the BCD. The remainder of exon VII encodes the transmembrane domain (TMD) of approx. 250 amino acids that includes the membrane-spanning helices TM1-TM7 (indicated by the hatched boxes), the extracellular and intracellular... Fig. 7.1 Localization of some mutations and polymorphisms reported for the calcium-sensing receptor (CASK). The relationship between the CASK gene exons (II to Vll) and the modular domains of the 1078-amino acid protein are indicated. The 610-amino acid exctracellular domain (BCD) is encoded by exons II to VI. The beginning of exon VII encodes the BCD. The remainder of exon VII encodes the transmembrane domain (TMD) of approx. 250 amino acids that includes the membrane-spanning helices TM1-TM7 (indicated by the hatched boxes), the extracellular and intracellular...
Yun, F. H., Wong, B. Y., Chase, M., et al. (2007) Genetic variation at the calcium-sensing receptor (CASR) locus Implications for clinical molecular diagnostics. Clin. Biochem. Biochem. 40, 551-556... [Pg.132]

Pidasheva, S., D Souza-Li, L., Canaff, L., Cole, D. E. C., and Hendy, G. N. (2004) CASRdb Calcium-sensing receptor locus-specific database for mutations causing familial (benign) hypocalciuiic hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant... [Pg.132]

Hendy, G. N., Minutti, C., Canaff, L., et al. (2003) Recurrent familial hypocalcemia due to germline mosaicism for an activating mutation of the calcium-sensing receptor gene. J. Clin. Endocrinol. Metab. 88, 3674-3681. [Pg.132]

Gunn, I. R., and Gaffney, D. (2004) Clinical and laboratory features of calcium-sensing receptor disorders a systematic review. Ann. Clin. Biochem. 41, 441 58. [Pg.132]

Leech, C., Lohse, P., Stanojevic, V., Lechner, A., Goke, B., and Spitzweg, C. (2006) Identification of a novel inactivating R465Q mutation of the calcium-sensing receptor. Biochem. Biophys. Res. Commun. 342, 996-1002. [Pg.132]

Hough, T. A., Bogani, D., Cheeseman, M. T., Favor, J., Nesbit, M. A., Thakker R. V., Lyon, M. F. 2004. Activating calcium-sensing receptor mutation in the mouse is associated with cataracts and ectopic calcification. Proc. Natl. Acad. Sci. U. S. A. 101(37) 13566-71. [Pg.133]

The Calcium-Sensing Receptor GPCR Variability in the Population... [Pg.141]

From the pharmacogenomic point of view, the calcium-sensing receptor (CASR) receptor differs from the majority GPCRs discussed in this chapter because it is not a family A receptor it is a member of family C. However, study of the vast number of CASR variants provides useful insight into the pharmacogenetic principles that... [Pg.141]

Chattopadhyay, N., Mithal, A., and Brown, E. M. (1996) The calcium-sensing receptor a window into the physiology and pathophysiology of mineral ion metabolism. Endocr. Rev. 17, 289-307. [Pg.169]

Lorentzon, M., Lorentzon, R., Lerner, U. H., and Nordstrom, P. (2001) Calcium sensing receptor gene polymorphism, circulating calcium concentrations and bone mineral density in healthy adolescent girls. Eur. J. Endocrinol. 144, 257-261. [Pg.169]

Miedlich, S., Lamesch, P., Mueller, A., and Paschke, R. (2001) Frequency of the calcium-sensing receptor variant A986S in patients with primary hyperparathyroidism. Eur. J. Endocrinol. 145,421 27. [Pg.169]

Donath, J., Speer, G., Poor, G., Gergely, P., Tabak, A., and Lakatos, P. (2004) Vitamin D receptor, oestrogen receptor-alpha and calcium-sensing receptor genotypes, bone mineral density and biochemical markers in Paget s disease of bone. Rheumatology. 43, 692-695. [Pg.169]

Vezzoli, G., Tanini, A., Ferrucci, L., et al. (2002) Influence of calcium-sensing receptor gene on urinary calcium excretion in stone-forming patients. J. Am. Soc. Nephrol. 13, 2517-2523. [Pg.169]

See other pages where Receptor calcium-sensing is mentioned: [Pg.491]    [Pg.75]    [Pg.132]    [Pg.133]    [Pg.247]    [Pg.261]    [Pg.109]    [Pg.133]    [Pg.139]    [Pg.167]    [Pg.169]    [Pg.169]    [Pg.184]    [Pg.331]   
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See also in sourсe #XX -- [ Pg.139 , Pg.140 , Pg.144 , Pg.544 ]

See also in sourсe #XX -- [ Pg.122 , Pg.155 , Pg.158 , Pg.161 , Pg.162 , Pg.163 , Pg.164 , Pg.165 , Pg.166 , Pg.182 , Pg.192 , Pg.193 , Pg.200 , Pg.201 , Pg.223 , Pg.224 , Pg.335 ]



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Calcium-sensing receptor Metabotropic glutamate receptors

Calcium-sensing receptor transduction

Extracellular Calcium-sensing Receptor

Sense receptor

Sensing calcium

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