Virustatics

Virustat (Delagrange) wfm Infermine (Hokuriku) Vilusron (Kanto)... 

Virustatic antimetabolites are false DNA building blocks (B) or nucleosides. A nucleoside (e.g., thymidine) consists of a nucleobase (e.g., thymine) and the sugar deoxyribose. In antimetabolites, one of the components is defective. In the body, the abnormal nucleosides undergo bioactivation by attachment of three phosphate residues (p.287). 

Among virustatic antimetabolites, acyclovir (A) has both specificity of the highest degree and optimal tolerability, 2000 Thieme... 

Inhibition of viral DNA polymerase B. Chemical structure of virustatic antimetabolites... 

Mecfianism of Action A synthetic nucleoside that converts to acyclovir triphosphate, becoming part of the DNA chain. Therapeutic Effect interferes with DNA synthesis and viral replication. Virustatic. 

Stahlmann R, Klug S, Foerster M, Neubert D (1993) Significance of embryoculture methods for studying the prenatal toxicity of virustatic agents. Reprod Toxlcol, 7(Suppl 1) 129-143. 

Leflunomide has anti-inflammatory, immunosuppressive, and virustatic effects. Its efficacy has been demonstrated in patients with rheumatoid arthritis and psoriatic arthritis and other conditions in randomized, double-blind, placebo-controlled trials and other studies (8-32), and it was approved for treatment of adult rheumatoid arthritis in August 1998 (Table 1) (33). In three large phase III trials (US301, n = 482 MN301, n = 358 MN302, n = 999), leflunomide was as effective and well tolerated as methotrexate and sulfasalazine and superior to placebo (34). These data were confirmed by a meta-analysis (35,36). Leflunomide is therefore indicated for patients with rheumatoid arthritis who have failed first-line disease modifying anti-rheumatic drug therapy on the basis of efficacy, safety, and costs (36). It is effective as monotherapy and in combination with methotrexate or infliximab (6). 

Ocular antiviral chemotherapy in the horse is adapted from that used in herpes simplex virus (HSV) and varicella zoster keratitis in humans. The agents used are nucleotide analogs capable of inhibiting viral replication by competitive inhibition of the uptake of the nucleotide into the viral genome. These agents are virustatic and require an intact immune system to suppress or eliminate the virus from the eye. They probably do not eradicate any latent infection. The antiviral drugs available currently do not penetrate intact comeal epithelium and are poorly disseminated within the comeal stroma. The availability of these dmgs will vary in different countries and some may only be obtained from hospital pharmacies. 

Antiparkinsonism because of increased release of dopamine. Virustatic. 

Ribavirin is a virustatic agent approved for administration as an aerosol for the treatment of lower respiratory tract infections caused by respiratory syncytial virus [93,94]. However, its therapeutic efficacy in this disease has come into question of late [95]. A newer group of antiviral agents have been developed that... 

Rimantadine hydrochloride (a-methyl-1-adamantanemethylamine hydrochloride) is a synthetic adamatane derivative that is structurally and pharmacologically related to amantadine (21,22). It appears to be more effective than amantadine hydrochloride against influenza A, with fewer CNS side effects. Rimantadine hydrochloride is thought to interfere with virus uncoating by inhibiting the release of specific proteins. It may act by inhibiting RT or the synthesis of virus-specific RNA, but it does not inhibit virus adsorption or penetration. It appears to produce a virustatic effect early in the virus replication. It is used widely in Russia and Europe. 

Sage reportedly has antibacterial, fungistatic, virustatic, astringent, secretion-stimulating, and perspiration-inhibiting effects. ... 

Kreutzberger, A. Schroeders, H.H. Antiviral agents. 4. Aromatically substituted carbonic acid amide structure in potentically Virustatic compounds. Arzneimittel-Forsch., 1975 vol 25, N° 7,994-997. 

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