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Amantadine hydrochloride

Amantadine hydrochloride [665-66-7] (1-adamantanamine hydrochloride, 41), C qH N HQ., (93) is a good example of a narrow-spectmm agent active only against influenza A vims. It became the first antiviral dmg available for systemic use in the United States when it was approved by the FDA in 1966 for use against Asian influenza. In 1976, FDA approval was extended to the use of amantadine for the reHef of symptoms of all influenza A strains. Amantadine is marketed by Du Pont de Nemours Co., Inc. A stmcturaHy related dmg, rimantadine hydrochloride [1501 -84-4] C 2H2 N HQ, (a-methyl-l-adamantanemethylamine hydrochloride, 42), is widely used in Russia to treat influenza A vims (94). [Pg.309]

Amantadine hydrochloride (Fig. 5.21A) does not prevent adsorphon but inhibits viral penetration. It has a very narrow spectrum and is used prophylachcally against infechon with influenza A vims it has no piophylachc value with other types of influenza... [Pg.124]

Loading dose on first day of 200 mg. Reproduced with permission from Horadam VW, Sharp JG, Smilack JD, et al. Pharmacokinetics of amantadine hydrochloride in subjects with normal and impaired renal function. Ann Intern Med. 1981 94 454-458. [Pg.1309]

King 1-week, single- 5 females Amantadine Amantadine hydrochloride, Four subjects experienced in-... [Pg.574]

B. G., Snape, M., Shernoff, E.W, Williamson, K., and Cook, E.H. (2001) Double-blind, placebo-controlled study of amantadine hydrochloride in the treatment of children with autistic disorder. / Am Acad Child Adolesc Psychiatry 40 658-665. [Pg.577]

FOOD TOXICANTS, NATURALLY OCCURRING] (Vol 11) Amantadine hydrochloride [665-66-7]... [Pg.38]

Kolbe F, Sitar DS, Papaioannou A, Campbell G. An amantadine hydrochloride dosing program adjusted for renal function during an influenza outbreak in elderly institutionalized patients. Canjf Clin Pharmacol. 2003 10 119-122. [Pg.543]

Amantadine hydrochloride Rimantadine hydrochloride Figure 7.17 Examples of host cell penetration inhibitors... [Pg.156]

Infra-red Spectrum. Principal peaks at wavenumbers 1503,1497, 1316,1603,1089,1517 (amantadine hydrochloride, KBrdisk). [Pg.333]

Amalie Acid Test, 129 Amanita, 407 Amantadine, 333 Amantadine hydrochloride, 333 Amantadine sulphate, 333 Amavil, 346 Ambaxin, 369 Ambazone, 334 Amben, 340... [Pg.1190]

SYNS ADAMANTANAMINE HYDROCHLORIDE ADAMANTINE HYDROCHLORIDE ADAMANTYL-AMINE HYDROCHLORIDE 1-ADAMANTYL-AMINE HYDROCHLORIDE AMANTADINE HYDROCHLORIDE AMAZOLON AMINO-ADAMANTANE HYDROCHLORIDE 1-AMNO-ADAMANTENE HYDROCHLORIDE EXP 105-1 MANTADAN NSC-83653 SYMMETREL TRICYCLO(3.3.1.1.07))DECAN-1-AMINE, HYDROCHLORIDE (9CI) VIROFRAL... [Pg.29]

Silver DE, Sahs AL. Livedo reticularis in Parkinson s disease patients treated with amantadine hydrochloride. Neurology 1972 22(7) 665-9. [Pg.107]

Nogaki H, Morimatsu M. Superficial punctate keratitis and corneal abrasion due to amantadine hydrochloride. J Neurol 1993 240(6) 388-9. [Pg.107]

See other pages where Amantadine hydrochloride is mentioned: [Pg.38]    [Pg.492]    [Pg.163]    [Pg.121]    [Pg.1308]    [Pg.1766]    [Pg.45]    [Pg.574]    [Pg.574]    [Pg.616]    [Pg.619]    [Pg.142]    [Pg.163]    [Pg.156]    [Pg.331]    [Pg.333]    [Pg.334]    [Pg.1074]    [Pg.1093]    [Pg.1146]    [Pg.1504]    [Pg.475]    [Pg.483]    [Pg.501]    [Pg.521]    [Pg.383]    [Pg.391]    [Pg.1763]    [Pg.12]    [Pg.12]    [Pg.23]   
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