Interaction virus-host

Bendahmane, M., Koo, M., Karrer, E., and Beachy, R.N. (1999). Display of epitopes on the snrface of tobacco mosaic virus impact of charge and isoelectric point of the epitope on virus-host interactions. J. Mol. Biol. 290, 9-20. 

Herpes Simplex. There are two types of herpes simplex virus (HSV) that infect humans. Type I causes orofacial lesions and 30% of the U.S population suffers from recurrent episodes. Type II is responsible for genital disease and anywhere from 3 x 104 — 3 107 cases per year (including recurrent infectionsi occur. The primary source of neonatal herpes infections, which are severe and often fatal, is the mother infected with type II. In addition, there is evidence to suggest that cervical carcinoma may be associated with HSV-II infection. Vaccine development is hampered by die fact that recurrent disease is common. Thus, natural infection does not provide immunity and the best method to induce immunity artificially is not clear. A much better understanding of the pathogenesis of die virus and virus-host interactions are required for the efficient development of the vaccine. 

A much better understanding of the pathogenesis of the vims and virus-host interactions are required for the efficient development of the vaccine. Recendy, DNA immunization is being proposed as a means to stimulate the appropriate Th 1 response which might provide long-term protection (81). 

Environmental factors influencing virus-host interactions... 

Mice have been used extensively to examine virus host interactions, and to examine virus-induced encephalitis. The adaptive immune response plays a crucial role in controlling WNV infections in mice, including encephalitis (Diamond et al., 2003 Shresta and Diamond, 2004 Wang et al., 2003). WNV infection leads to a Toll-like receptor 3-dq3endent inflammatory response, which promotes brain penetration of the virus, neuronal injury, and enhanced encephalitis (Wang et al., 2004). Since Toll-like receptor 3 recognizes double-stranded RNA and promotes an innate immune response, this finding... 

Tsichlis P.N. and Lazo P.A. (1991). Virus-host interactions and the pathogenesis of murine and oncogenic retroviruses. Curr. Top. Microbiol. Immuna 171 95-171. 

Mousepox a model for study of virus-host interactions and smallpox... 

C54okines produced in the brain play an important role in virus-host interaction that may influence viral spread and gene expression and consequently the functioning of neural cells (D Arcangelo et al, 1991 Merrill and Chen, 1991 ... 

The identification of a gene with a role in virus-host interaction is only the first step in understanding virus-host interactions. The specific mode of action must be... 

Both rodent CM Vs provide useful systems to analyse virus-host interactions and hence to discern the role of immune-evasive proteins encoded by their genomes. In the case of MCMV, a wealth of knowledge concerning the importance of host genetic factors and dissection of various compartments of the immune response in... 

All tailed phages have evolved tailspike and fiber proteins for efficient virus-host-interactions. These specialized adhesions mediate the recognition and attachment to the bacterial surface and constitute the key determinants for host specificity. Interestingly, many spikes and fibers are composed of homotrimeric complexes which remain stable even in the presence of sodium dodecyl sulfate (SDS) [12, 14, 30-34], Several phages have developed tailspike proteins with an enzymatic activity in order to penetrate the thick layer of lipopolysaccharides or capsular polysaccharides of many pathogenic bacteria. These capsule-specific depolymerases (hydrolases or lyases) are required to gain access to and to fix the phage at the bacterial outer membrane [13, 14, 35-38]. 

In this chapter, we will explore the importance of proteomics in studying virus-host interactions in several viral systems including HCMV, KSHV, EBV, HSV, HIV-1, HTLV-1, and HCV. We will also describe the methods that have been employed to study viral disease progression using several techniques including 2DE, LC-MS/MS, SELDI, and protein microarrays. 

Marcus, P. I., 1959, Symposium on the biology of cells modified by viruses or antigens. IV. Single-cell techniques in tracing virus-host interactions, Bacteriol. Rev. 23 232. 

Schlesinger, R. W., 1980, Virus-host interactions in natural and experimental infections with alphaviruses and flaviviruses, in The Togaviruses (R. W. Schlesinger, ed.), pp. 83-106, Academic Press, New York. 

Virus-Host Interactions Receptors, Persistence and Neurological Diseases... 

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