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Viruses host cell interactions

The strategies just described are in principle also applicable to other viral vectors, and a number of studies describing such approaches have been published, mainly for adeno-associated viruses (AAV) [45-47] and retroviruses [48-50], It can be anticipated that this field will rapidly expand as the mechanisms of virus-host cell interactions are unraveled in detail. [Pg.270]

Dubovi EJ, Geratz JD, Shaver SR, Tidwell RR (1981) Inhibition of respiratory syncytial virus-host cell interactions by mono- and diamidines. Antimicrob Agents Chemother 19 649-656... [Pg.194]

THE VIRUS-HOST CELL INTERACTION—INTRACELLULAR REPRODUCTION... [Pg.176]

Ionizing and ultraviolet radiation (UV) inactivate both free and intracellular virus with high efficiency (178). The inactivation of extracellular virus is considered next inactivation of intracellular virus is the basis of a method for studying virus development described later under Virus-Host Cell Interaction. In general, the sensitivity of viruses to... [Pg.230]

Ebola vims) envelope protein that is pseudotyped with an HI V vector. Pseudotyping was chosen as a strategy since it can allow for efficient gene transfer into specific tissues via a particular cellular domain this is based on the well-known fact that the viral envelope contributes to the tropism of the vims and determines if a virus-host cell interaction will occur. This particular vector has been shown to transduce efficiently intact airway epithelium from the apical sutfece in both in vitro and in vivo model systems (13). [Pg.577]

The endoparasite C. sonorensis has evolved with the ability to generate extrachromosomal genetic elements in the form of multiple double-stranded, superhelical DNA molecules. These DNA molecules are amplified in the calyx cell nucleus, packaged into viruses, and secreted in a complex process of viral maturation, which also provides a complex double viral envelope. One viral envelope is assembled in the cell nucleus, and the other is obtained during budding from the calyx cell surface into the oviduct lumen. Viral envelopes, which are derived from cellular membranes, may mediate species-specific virus host cell and tissue interactions. This could be one important aspect of the species-specific endoparasite-host relationship fundamental to parasite survival. [Pg.88]

The F protein is synthesized as a single polyprotein (Fo) comprising 574 amino acids that is activated to the fusion-competent form by a host cell endoprotease, which produces a disulfide-linked heterodimer designated Fi and F2. The carboxy terminus of F2 is the site of cleavage, a process that reveals the hydrophobic amino acids at the amino terminus of Fi as the fusion peptide (Fig. 3) [65, 66]. The processed peptide assembles on the surface of the virion in an oligomeric form, most probably as a trimeric species, and mediates virus-host cell membrane fusion in a fashion that is not dependent on endocytosis. The F protein has also been shown to interact with the cell surface proteins intercellular adhesion molecule-1 (ICAM-1) and nucleolin, which provide potential avenues for vims entry in the absence of the G or SH proteins [67, 68]. [Pg.170]

Marcus, P. I., and Puck, T. T., 1958, Host-cell interaction of animal viruses. I. Titration of cell-killing by viruses. Virology 6 405. [Pg.59]

Abstract The entry of viruses into target cells involves a complex series of sequential steps, with opportunities for inhibition at every stage. Entry inhibitors exert their biological properties by inhibiting protein-protein interactions either within the viral envelope (Env) glycoproteins or between viral Env and host-cell receptors. The nature of resistance to entry inhibitors also differs from compounds inhibiting enzymatic targets due to their different modes of action and the relative variability in... [Pg.177]


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