Cation vinylic

Evidence from a variety of sources however indicates that alkenyl cations (also called vinylic cations) are much less stable than simple alkyl cations and their involve ment m these additions has been questioned Eor example although electrophilic addi tion of hydrogen halides to alkynes occurs more slowly than the corresponding additions... 

Highly unstable vinyl cations, generated in situ from vinyl triflates have also been arylated (the triflate group is replaced by the aromatics) to give vinyl aromatics under Friedel-Crafts conditions (28). 

Acylation of acetylenic compounds provides /ra/ j -P-chlorovinyl ketones (181). Vinyl cations were proposed to be the intermediates in these reactions. 

When aiomatics aie present, they can capture the intermediate vinyl cation to give P-aryl-a,P-unsatutated ketones (182). Thus acylation of alkyl or aryl acetylenes with acyhum salts in the presence of aromatics gives a,P-unsaturated ketones with a trisubstituted double bond. The mild reaction conditions employed do not cause direct acylation of aromatics. 

Increased sensitivity towards acid is observed when protonation occurs on a functional group outside the diazirine ring, giving rise to electron dilution at the carbon atom adjacent to the diazirine carbon. The products isolated are in accord with the proposal (79AHC(24)63) that cation formation at this carbon atom leads to nitrogen extrusion, probably with formation of a vinyl cation. Thus protonated hydroxydiazirine (209) yields acetone, and methylvinyldiazirine (199) on treatment with acids yields butanone (67CB2093). 

Especially sensitive towards acid is the ketodiazirine (200). It decomposes on contact with O.IN acid, forming methylenecyclopentanone (213) and cyclopentanecarboxylic acid (214). The products may be formed from a developing vinyl cation (212) by C—C bond shift either to the double bond (213) or across the double bond (214) (B-67MI50800). 

Both experimental studies on gas-phase ion stability and MO calculations indicate that the two vinyl cations shown below benefit fiom special stabilization. Indicate what stmctural features present in these cations can provide this stabilization. 

The three basic mechanisms that have been considered to be involved in electrophilic additions to alkynes are shown below. The first involves a discrete vinyl cation. In general, it can lead to either of the two stereoisomeric addition products. The second mechanism is a termolecular process which would be expected to lead to stereospecific anti addition. The... 

Alkynes react when heated with trifluoroacetic acid to give addition products. Mixtures of syn and anti addition products are obtained. Similar addition reactions occur with trifluoromethanesulfonic acid. These reactions are analogous to acid-catalyzed hydration and proceed through a vinyl cation intermediate. 

The monosubstituted intermediate does not seem to be effectively bridged, since syn addition predominates. Avery short-lived vinyl cation appears to be the best description of the intermediate in this case. ... 

The stereochemistry of addition is usually anti for alkyl-substituted alkynes, whereas die addition to aryl-substituted compounds is not stereospecific. This suggests a termo-iecular mechanism in the alkyl case, as opposed to an aryl-stabilized vinyl cation mtermediate in the aryl case. Aryl-substituted alkynes can be shifted toward anti addition by including bromide salts in the reaction medium. Under these conditions, a species preceding the vinyl cation must be intercepted by bromide ion. This species can be presented as a complex of molecular bromine with the alkyne. An overall mechanistic summary is shown in the following scheme. 

This scheme represents an alkyne-bromine complex as an intermediate in all alkyne brominations. This is analogous to the case of alkenes. The complex may dissociate to a inyl cation when the cation is sufficiently stable, as is the case when there is an aryl substituent. It may collapse to a bridged bromonium ion or undergo reaction with a nucleophile. The latta is the dominant reaction for alkyl-substituted alkynes and leads to stereospecific anti addition. Reactions proceeding through vinyl cations are expected to be nonstereospecific. 

The allylic carbocation resulting from protonation of the center carbon might seem the obvious choice, but, in fact, the kinetically favored protonation leads to the vinyl cation... 

The kinetic features of this reaction, including the solvent isotope effect, are consistent with a rate-determining protonation to form a vinyl cation. ... 

Vinyl Inflates permit alkylation with vinyl cations [24, 25] Fluorobenzene reacts with 2 methyl 1-phenyl 1 propenyl triflate to form a diaryl alkene [24J (equation 17)... 

An interesting class ot covalent Inflates are vin l and ar>/ or heteroaryl Inflates Vinyl inflates are used for the direct solvolytic generation of vinyl cations and for the generation of unsaturated carbenes via the a-elimination process [66] A triflate ester of 2-hydroxypyridine can be used as a catalyst for the acylation of aromatic compounds with carboxylic acids [109] (equation 55)... 

The first step in the addition of an electrophile such as HBr to an alkyne involves protonation and subsequent formation of an intermediate vinyl cation. Where does propyne protonate Compare energies of 1-methylvinyl and 2-methylvinyl cations. Which is more stable Why Measure CC bond distance in the more stable cation. Does the cation incorporate a full triple bond (as in propyne) or a double bond (as in propene). Examine atomic charges and electrostatic potential maps to locate the positive charge in the two cations. Is the more stable ion the one in which the charge is better delocalized Use the charges together with information about the ions geometry to draw Lewis structures (or a series of Lewis structures) for 1-methylvinyl and 2-methylvinyl cations. 

The stage is now set for the crucial polycyclization event. Tertiary carbinol 8, derived from the action of methyllithium on enone 9, is a rather unstable substance, and it was submitted to the polycyclization reaction without purification. When intermediate 8 is treated with trifluoroacetic acid (TFA) and the vinyl cation trapping agent ethylene carbonate in 1,2-dichloroethane at 0°C, the desired... 

Metalated epoxides can react with organometallics to give olefins after elimination of dimetal oxide, a process often referred to as reductive alkylation (Path B, Scheme 5.2). Crandall and Lin first described this reaction in their seminal paper in 1967 treatment of tert-butyloxirane 106 with 3 equiv. of tert-butyllithium, for example, gave trans-di-tert-butylethylene 110 in 64% yield (Scheme 5.23), Stating that this reaction should have some synthetic potential , [36] they proposed a reaction pathway in which tert-butyllithium reacted with a-lithiooxycarbene 108 to generate dianion 109 and thence olefin 110 upon elimination of dilithium oxide. The epoxide has, in effect, acted as a vinyl cation equivalent. 

The vinyl cation (Fig. 40 and III.13) in which the empty p orbital on the positive center is coplanar with the terminal methylene group, is clearly another candidate for hyperconjugative donation. The in-plane orbital readily overlaps with the odd p orbital, with formation of two delocalized orbitals and an energy gain... 

Phenyl 2-(trimethylsilyl)ethynyl sulfone (118) can act as a vinyl cation synthon (equations 93 and 94)78 79. Thus, the reaction of enolates with 118 and subsequent desulfonylation of the adduct gives a-vinyl ketone, such as 119 and 120. 

Evidence for the occurrence of vinyl cations as short-lived intermediates in solvolysis and other reactions has accumulated in the last few years (reviewed by Hanack, 1970, by Richey and Richey, 1970, and by Modena and Tonellato, 1971), but they have not been observed spectroscopically. It has been shown possible to intercept some vinyl cations—prepared in a system of extremely low nucleophilicity (EHSO3—SbEj 1 1-1 10) by protonation of propyne and 2-butyne— by carbon monoxide (Hogeveen and Roobeek, 1971b). The oxocarbo-nium ions formed in these cases are shown in the following scheme ... 

In contrast to the results of the reaction of tertiary and secondary alkyl cations with carbon monoxide (Figs. 1-5), which were obtained under thermodynamically controlled conditions, the results of the carbonylation with the vinyl cations were obtained under kinetically controlled conditions. This presents a difficulty in explaining the occurrence of the 1,2-CH3 shift in the reaction 16->-17, because it involves a strong increase in energy. The exclusive formation of the Z-stereoisomer 18 on carbonylation of the 1,2-dimethylvinyl cation 16 is remarkable, but does not allow an unambiguous conclusion about the detailed structure— linear 19 or bent 20—of the vinyl cation. A non-classical structure 21 can be disregarded, however, because the attack... 

Kinetic data on the carbonylation of vinyl cations have not been obtained so far, but it is likely to be a diffusion-controlled reaction as in the case of primary alkyl cations (Section IV, A). 

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