Vibrio cholerae cholera

Listeria Proliferation in cytoplasm of different Vibrio cholerae Cholera toxin - enterotoxin (main dehydrating ... 

Cholera Vibrio cholerae cholera Results in activation of adenylate cyclase which elevates cAMP, leading to changes in intestinal epithelial cells that cause loss of water and Na ions from the cells to the lumen of the intestine... 

The toxins produced by Bordetella pertussis (pertussis toxin) and Vibrio cholerae (cholera toxin) modify functions of certain G proteins to produce their pathoiogicai effects. 

We consider here some pathologies of the G-protein-dependent signal pathways. Let us first consider the mechanism of action of the cholera toxin, secreted by the intestinal bacterium Vibrio cholera. Cholera is an acute diarrheal disease that can be life threatening. It causes voluminous secretion of electrolytes and fluids from the intestines of infected persons. The cholera toxin, choleragen, is a protein composed of two functional units—a B subunit that binds to gangliosides of the intestinal epithelium and a catalytic A subunit that enters the cell. The A subunit... 

Some of the G rroteins are substrates for ADP-ribosylation by bacterial toxins. Specifically, toxins from Vibrio cholera, cholera toxin (CT) or Bordetella pertussis, pertussis toxin (PT), can covalently modify the G roteins by addition of an ADP-ribose... 

In the wider sense, protein toxins localized in the cytoplasm of Gram-negative bacteria are also designated as E., for example, toxins of Vibrio cholerae ( cholera toxin), the bacteriocins (e. g colicins) or the polypeptides y-E. formed by Bacillus thuringiensis which represent up to 30% of the cell weight and are used in plant protection as antifeedants against insect pests. 

Vibrio cholerae Cholera Watery diarrhea, vomiting, fever, dehydration, abdominal cramps Contaminated water and food... 

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