Vibrio cholerae toxin production

Bordetellapertussis, Corynehacterium diphtheriae, Vibrio cholerae). This is, to a large extent, a reflection of their inability to combat that host s deeper defences. Survival at these sites is largely due to firm attachment to the epithelial cells. Such organisms manifest disease through the production and release of toxins (see below). 

Mechanism of action of cholera toxin. The steps consist of cholera toxin (CT) binding to GMi receptors anchored by its ceramide moiety internalization of CT in endosomes the release of A1-subunit of CT from the trans-Golgi network and endoplasmic reticulum (ER) ADP ribosylation of the a-subunit of stimulatory G-protein by At activation of adenylyl cyclase and production of cAMP activation of protein kinase A phosphorylation of the regulatory (R) subunit of CFTR and finally opening of the chloride channel. Vibrio cholerae also produces a zona occludens toxin (ZOT) which increases the ionic permeability of the zona occludens. 

Vibrio cholerae 16-72 Water Toxin production (in vivo) 2-12 day Supportive, antibiotics... 

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