Veterinary drug residues chromatography

E. Martlbauer, R. Dietrich, and E. Usleber, Immunoaffinity chromatography as a tool for the analysis of antibiotics and sulfonamides, in Veterinary Drug Residues, Food Safety, ed. WA. Moats and M.B. Medina, American Chemical Society, Washington, DC, Chapter 13, pp. 121-131 (1995). 

Multiresidue analysis has been carried out using conventional chromatographic methods, such as HPLC, gas chromatography (GC), and capillary electrophoresis. In the special case of veterinary drug residues, conventional microbiological methods can also be performed based on the inhibition of growing of bacteria promoted by the antibiotic. 

An evaluation of the scientific literature reveals that over 500 papers on veterinary drug residue analysis were published in the 5-year period of 2005-2009. Liquid extraction (LE) and liquid-solid extraction (LSE) were found to be very popular sample treatment techniques that were used in 30% and 60% of the reported studies, respectively. Here, LE includes all liquid-based approaches such as liquid-liquid extraction (LLE), extrelut liquid-liquid extraction, liquid-liquid micro-extraction, and pressurized liquid extraction (PLE). LSE includes solid phase extraction (SPE) and all other sorbent-based extraction procedures, such as solid phase micro-extraction (SPME), stir bar sorptive extraction (SBSE), restricted-access materials (RAM), turbulent-flow chromatography (TEC), dispersive SPE (dSPE), and matrix solid phase dispersion... 

Ultra-high-performance liquid chromatography has been increasingly used for the determination of multi-residue or multi-class antibiotics in food (Table 6.1). For example, an UHPLC/ESI-MS/MS method was reported to simultaneously analyze 17 different veterinary drug residues belonging to several classes of antibiotics such as macrolides, tetracyclines, quinolones, and sulfonamides... 

Van der Heeft E, Bolck YJC, Beumer B, Nijrolder AWJM, Stalker AAM, Nielen MWF, Full-scan accurate mass selectivity of ultra performance hquid chromatography combined with time-of-flight and orbitrap mass spectrometry in hormone and veterinary drug residue analysis, J. Am. Soc. Mass Spectrom. 2009 20(3) 451-463. 

Li H, Kijak PJ, Turnipseed SB, Cui W, Analysis of veterinary drug residues in shrimp a multi-class method by liquid chromatography-quadrupole ion trap mass spectrometry, J. Chromatogr. B 2006 836(l-2) 22-38. 

Balizs, G. Hewitt, A. Determination of veterinary drug residues by liquid chromatography and tandem mass spectrometry. Anal. Chim. Acta 2003,492,105 131. 

Aguilera-Luiz, M. M., Romero-Gonzalez, R., Plaza-Bolanos, P, Vidal, J. L. M., and Frenich, A. G. 2013. Rapid and semiautomated method for the analysis of veterinary drug residues in honey based on turbulent-flow hquid chromatography coupled to ultra high-performance hquid chromatography-orbitrap mass spectrometry (TFC-UHPLC-Orbitrap-MS). J. Agr. Food Chem. 61 829—839. 

Kaufmann, A. 2009. Quantitative analysis of veterinary drug residues by sub 2-p,m particulate high-perfromance liquid chromatography columns and time-of-flight mass spectrometry (UPLC-TOF). In Liquid chromatography time-of-flight mass spectrometry principles, tools, and applications for accurate mass analysis, edited by I. Ferrer and E. M. Thurman, pp. 133-1 SOWiley, Hoboken, New Jersey. 

Determination of Veterinary Drug Residues in Foods by Liquid Chromatography—Mass Spectrometry Basic and Cutting-Edge Applications... 

Boscher A, Guignard C, Pellet T, Hoffman L, Bohn T. Development of a multi-class method for the quantification of veterinary drug residues in feedingstuffs by liquid chromatography—tandem mass spectrometry. J Chromatogr A 2010 1217 6394-404. 

Stubbings G, Bigwood T. The development and validation of a multiclass liquid chromatography tandem mass spectrometry procedure for the determination of veterinary drug residues in animal tissue using a QuEChERS (QUick, Easy, CHeap, Effective, Rugged and Safe) approach. Anal Chim Acta 2009 637 68-78. 

Yamada R, Kozono M, Ohmori T, Morimatsu F, Kitayama M, Simultaneous determination of residual veterinary drugs in bovine, porcine, and chicken muscle using hq-uid chromatography coupled with electrospray ionization tandem mass spectrometry, Biosci. Biotech. Biochem. 2006 70 54-65. 

Aguilera-Luiz MM, Vidal JLM, Romero-Gonzalez R, Frenich AG, Multi-residue determination of veterinary drugs in milk by ultra-high-pressure liquid chromatography-tandem mass spectrometry, J. Chromatogr. A 2008 1205 10-16. 

The correct implementation of surveillance and residue monitoring programs involves the development of robust and sensitive analytical methods to provide control authorities with effective tools. Since veterinary drugs are generally quite polar and thermolabile compounds, liquid chromatography coupled to mass spectrometry (LC—MS) has become the predominant methodology for determination of these substances in foods [4]. 

Jemal, M. and Quyang, Z. (2003) Rapid Com-mun. Mass Spectrom., 17, 24—38. Kaklamanos, G., Vincent, U., and von Holst, C. (2013) Multi-residue method for the detection of veterinary drugs in distillers grains by liquid chromatography-Orbitrap high resolution mass spectrometry. /. Chromatogr. A, 1322, 38—48. 

Scopus search veterinary and drugs and determination and chromatography and extraction and food and tissue and residues and cleanup time period 2005-2010 (available at http //WWW.scopus.com). 

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