Valerian Valeriana officinalis

Valerian Valeriana officinalis Restlessness, sleep disorders Rare if used as directed. May interact with the barbiturates (eg, phenobarbital), the benzodiazepines (eg, diazepam) and the opiates, (eg, morphine). 

Valerian Valeriana officinalis). Reprinted from Culbreth DMR. (1927). Materia Medica and Pharmacognosy, 7th ed. Philadelphia Lea Febiger. 

Valerian (Valeriana officinalis) Reduces nervousness and insomnia... 

Plushner, S.L. (2000) Valerian Valeriana officinalis. Am Health Syst Pharm 57 328-335... 

Valerian Valeriana officinalis (Valeri anaceae) Valeranone... 

Valerian Valeriana officinalis) The roots of this plant are dried to produce a potent extract that induces sleepiness and helps treat insomnia. Like lavender, it depresses the activity of the central nervous system in a fashion similar to stronger prescription tranquilizers such as benzodiazepines and barbiturates, but without the dulling or hangover effects the next day or impairing the ability to drive a car. 

Tea Tree (Melaleuca alternifolia) Uses Rx of superficial wounds (bacterial, viral, fungal, insect bites, minor burns, cold sores, acne Action Broad-spectrum antibiotic activity against E. coli, S. aureus, C. albicans Available forms Topical creams, lotions, oint, oil apply topically PRN Notes/SE Ataxia, contact dermatitis, D, drowsiness, GI mucosal irritation Interactions Effects OF drugs that affect histamine release EMS effects of Benadryl Valerian (Valeriana officinalis) Uses Anxiolytic, antispasmodic, dys-menorrheal, restlessness, sedative Action Inhibits uptake stimulates release of GABA, which T GABA concentration extracellularly causes sedation Available forms Ext 400-900 mg PO 30 min < hs, tea 2-3 g (1 tsp of crude herb) qid, PRN, tine 3-5 mL (1/2-1 tsp) (1 5 ratio) PO qid, PRN Efficacy Probably effective sedative (reduces sleep latency) Notes/SE GI upset, HA, insomnia, N/V, palpitations, restlessness, vision changes Interactions T Effects OF barbiturates, benzodiazepines, opiates, EtOH, catnip, hops, kavakava, passion flower, skullcap effects OF MAOIs, phenytoin, warfarin EMS T Effects of benzodiazepines and opiates abruptly D/C may cause withdrawal symptoms... 

Valerian Valeriana officinalis Root of the valerian plant Sedative-hypnotic and antianxiety effects... 

Valerian Valeriana officinalis (-)-Bornyl acetate (62), 3-methylbutanoic acid 95,105... 

Valerian (Valeriana officinalis) is found in temperate re-giotis of North America. Europe, and Asia. The dried rhizome of valerian contains an unpleasant-smelling volatile oil that is attributed to isovaleric acid. Despite the (xinr. valerian is a safe and effective sleep aid. 

Valerian (Valeriana officinalis) Valerian is a mild sedative and induces sleep similar to benzodiazepines (Benadryl). Valerian has an odor of dirty socks, reducing the risk for an overdose. Valerian may lead to habituation and addiction. 

Valerian A drug consisting of the dried rhizome and roots of the common valerian, Valeriana officinalis, used as a carminative, especially in nervous affections. 

Valerian Valeriana officinalis 1 Valerine alkaloids used as mild tranquilizer... 

An ethanol extract of valerian (Valeriana officinalis) was shown to modestly prolong thiopental anaesthesia in mice, possibly via its effects on the GABA-benzodiazepine receptor."... 

Donovan, J.L., C.L. DeVane, K.D. Chavin, et al. 2004. Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers. Drug Metab. Dispos. 32(12) 1333-1336. 

C,oH,t, Mr 136.24, oil. Isomeric bicyclic raonoter-penes ( SARH-)-a-E, bp. 155-158°C, [a]D-32 (neat) fi-E, bp. 153 °C, [a]D +84.9° (neat). a-F. occurs in the essential oil of leaves of the western red cedar (Thuja plicata, Cupressaceae) and the medicinal valerian (Valeriana officinalis, Valerianaceae) while P-F. occurs in the fruits of common caraway (Carum carvi, Apiaceae). ... 

Camphene, with its slight camphoric odor, is used in perfumery and is derived from the isocamphane skeleton its enantiomers readily undergo racemization and occur as such or as the racemate in bergamot oil, as well as in the oils of citronella and turpentine. (+)-a-Fenchene is found in the ethereal oils of the giant tree of life Thuja plicata (Cupressaceae) and valerian Valeriana officinalis (Valerianaceae), (+)-P-fenchene in the fruits of caraway Carum carvi (Umbellifereae). 

In contrast, valeranes arising from migration of flie methyl group C-15 in eudesmane from C-4 to C-5, in contrast, very rarely occur. Examples include the va-lerenones from the roots of valerian Valeriana officinalis and from Nardostachys jatamansi (Valerianaceae). 

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