PLGA-Based DDS

Various DDSs based on PLGA have been developed in recent times. The developed DDS includes microparticles, nanoparticles, injectables, dry powder for inhalation, 

Brand Name Active Ingredient Company Indication Route Status 

1 Nutropin Depot Human growth hormone Genetech Growth deficiencies SC/IM Marketed 

2 Lupron Depot Leuprolide acetate TAP Prostate cancer Marketed 

3 Suprecur MP Buserelin acetate Aventis Prostate cancer Marketed 

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There are various factors which affect the release of drug from the PLGA-based DDS (Figure 6.1). The drug release from PLGA-based DDS has been beautifully reviewed by Fredenberg et al. [30]. 

Figure 6.1 Various processes taking part in drug release from PLGA-based DDS (Adapted from Elsevier).

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