Unscheduled DNA Synthesis test

Hoechst. 1988d. Evaluation of endosulfan - substance technical (code HOE 02671 OI ZD95 0005) in the unscheduled DNA synthesis test in mammalian cells in vitro. Hoechst Aktiengesellschaft, Frankfurt, Germany. Study no. 88.0106. [unpublished study]... 

Unscheduled DNA Synthesis Test Using Primary Rat Hepatocytes. 307... 

TETA was mutagenic in bacterial assays and was positive in sister chromatid exchanges and unscheduled DNA synthesis tests in vitro It was not clastogenic in the mouse micronucleus test in vivo after oral or intraperitoneal administration. 

Unscheduled DNA synthesis test with mammalian liver cells in vitro UDS in vitro DNA repair DNA repair synthesis... 

Unscheduled DNA Synthesis Test with Mammalian Liver Cells in vitro... 

Sister chromatid exchange analysis in spermatogonia Unscheduled DNA synthesis test (UDS) in testicular cells... 

Alosetron was not genotoxic in the Ames tests, the mouse lymphoma cell (L5178Y/TK +) forward gene mutation test, the human lymphocyte chromosome aberration test, and the rat hepatocyte unscheduled DNA synthesis test. Nonmutagenic in the rat micronucleus assay. 

Using the Ames Salmonella test, prometryn was not mutagenic when tested up to the cytotoxic solubility limits. Prometryn was negative for bacterial DNA repair and gene mutation in an unscheduled DNA synthesis test using rat hepatocytes. 

Quercetin, a flavonoid component of St. John s wort and several other medicinal plants, has been implicated as a mutagen. However, St. John s Wort aqueous ethanolic extract showed no mutagenic effects in mammalian cells. Tests used included the HGPRT (hypoxanthine guanidine phosphoribosyl transferase) test, the UDS (unscheduled DNA synthesis) test, the cell transformation test uring Syrian hamster embryo cells, the mouse fur spot test, and the chromosome aberration test using Chinese hamster bone marrow cells (Okpanyi et al., 1990). 

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