Uncontrollable risks

Number of previously uncontrolled risks identified and corrected... 

Uncertainty from the viewpoint of the discovery researcher consists both of controllable and uncontrollable risks [23],... 

Aleatory uncertainty —the roll of the die—describes risks that cannot practicably be predicted within the research process, for example, new failure modes, or modes that can only be detected in late stages of work, for example, humans. An example of aleatory uncertainty is the withdrawal in the UK of Bextra on the basis of two serious adverse events out of 40,000 patients this could only be discovered after launch [2]. This, without hindsight, was an uncontrollable risk. ... 

Provides a 6-level (high level rntemal/extemal low level controllable / partially controUable/uncontrollable) risk classification and identifies up to 25 sources of risk. Ranks them using AHP... 

Accident statistics will be useful in identifying uncontrolled risks as they will present- if properly analysed from a causal viewpoint-data indicative of where control action should have been taken to prevent recurrence. Ideally, an analysis of all injury, damage and near-miss accidents should be undertaken, so that underlying trends may be highlighted and effective control action - both organisational and physical in nature - taken. 

Uncontrolled risk is unacceptable within an organization as the rules and regulations it must legally follow are different. For example, employees may on their own time take extreme risk, such as sky diving, rock climbing, driving a vehicle on weekends without using a seat belt, etc. The concern is that this mindset of risk acceptance may get into the workplace unless a mechaiusm is in place to prevent unacceptable risk. 

If leaks, spills or uncontrolled releases of a hazardous substance could occur, means are required for limiting the extent of health risks and for regaining adequate control as soon as possible. Where appropriate means should include ... 

The enthalpy of decomposition is now replaced by the enthalpy of reaction to analyse the potential danger. Since the danger of a chemical reaction is usually related to a modification in its procedure, which makes it uncontrollable and causes destruction of the molecular groups, it seems to make more sense to write down the most energetic reaction possible. The risk will indicate the maximum potential danger considering the stoichiometry chosen. This approach may be... 

Factors that increase the risk of bleeding must be evaluated before thrombolytic therapy is initiated (i.e., recent surgery, trauma or internal bleeding, uncontrolled hypertension, recent stroke, or intracranial hemorrhage)... 

Psychiatric adverse effects occur frequently and may include irritability, depression, and rarely, suicidal ideation. Individuals with a history of uncontrolled psychiatric disorders must weigh the risk versus benefit of treatment, as interferon may exacerbate or worsen the psychiatric condition. Patients who develop mild to moderate symptoms may require antidepressants or anxiolytics. Those with severe symptoms including suicidal ideation should have the treatment discontinued immediately.43... 

Almost no one dies from opioid withdrawal per se however, underlying medical complications (e.g., hypertension or recent myocardial infarction) increase the risk of death. Therefore, it is important to manage and stabilize any medical issues (i.e., uncontrolled blood pressure or diabetes, among others), and then determine if hospitalization is appropriate. Patients with... 

Because prostheses are the most invasive treatment available, they are only considered in patients who do not respond to medications or external devices, or those who have significant adverse effects from other therapies. Patient satisfaction rates can be as high as 80% to 90% with partner satisfaction rates just slightly lower.9 The primary risks of insertion of prostheses are infection and device failure, although these only happen in 2% to 3% and 2% to 14% of patients, respectively. Higher infection rates have been reported in uncontrolled diabetic patients, paraplegics, and patients undergoing reimplantation or penile reconstruction.14,15 Most prostheses can be expected to last from 7 to 10 years.16... 

Suicide risk even in patients without psychiatric disease Avoid in uncontrolled narrow-angle glaucoma (causes mydriasis) Hepatotoxic avoid in alcoholics even if signs/symptoms of hepatic disease are absent. 

Indomethacin was used traditionally, but its relative cyclooxygenase-1 (COX-1) selectivity theoretically increases its gastropathy risk. Thus other generic NSAIDs may be preferred. Adverse effects of NSAIDs include gastropathy (primarily peptic ulcers), renal dysfunction, and fluid retention. NSAIDs generally should be avoided in patients at risk for peptic ulcers, those taking warfarin, and those with renal insufficiency or uncontrolled hypertension or heart failure. 

Hydrogen chloride and chlorine gases form when chlorinated organic compounds in hazardous wastes are burned. If uncontrolled, this chlorine can become a human health risk and is a large component in the formation of acid rain. U.S. EPA has developed different requirements to control the emissions of chlorine from the different classes of combustion units. 

The reaction between acrylonitrile and formaldehyde (as paraformaldehyde or tri-oxane), under strong acid catalysis (usually sulphuric) and most often in presence of catalytic quantities of acetic anyhydride, to produce triacrylohexahydrotriazine, is inclined to violent exotherm after an induction period. The runaway can be uncontrollable on sub-molar scale. It may be due to acrylate polymerisation or to increasing reactivity of the formaldehyde equivalent due to progressive de-oligomerisation. Procedures claimed to prevent the risk have been described in the literature but do not seem reliable. 

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