Ulcer drugs

An aryloxypyrimi done has been described as an anti ulcer agent this activity is of note since the agent does not bear any structural relation to better known anti ulcer drugs. Displacement of halogen on the acetal of chloro-acetaldehyde by alkoxide from m-cresol gives the intermediate This affords enaminoaldehyde when subjected... 

Antitussive drugs, 3 (1963) 89 Anti-ulcer drugs, of plant origin, 28 (1991) 201... 

Hospital specialists will readily start to prescribe a new product if they are convinced of its safety and efficacy, provided it is for use in their own specialty. They are much less ready to try a new compound if it is outside their area of expertise. A cardiologist, for example, would be much less likely to try a new anti-ulcer drug than an antihypertensive until first discussing it with a gastroenterologist colleague. 

The combined toxicity of commodation (the active ingredient in the anti-ulcer drug Tagamet) and the insecticide diazinon is being investigated in a study at the National Institute of Environmental Health Sciences in an effort to determine if simultaneous exposure to these two compounds might enhance the toxicity of diazinon. Results of these studies indicate that diazinon is very rapidly metabolized and that simultaneous exposure to commodation has little effect on the half-life of diazinon but does alter the ratio of some metabolites formed. 

Cu chelates of anti-inflammatory and anti-ulcer drugs were often found more active than the free ligands The structure of the Cu(ll) complexes of the anti-... 

Certain drugs can reduce the ability of the liver to clear benzodiazepines from the body. These include ulcer drugs, such as cimetidine (Tagamet), birth control pills, propranolol (used to treat hypertension, heart disorders, and migraines), and disulfuram (Antabuse), which is used for the treatment of alcoholism. 

In 1999, worldwide sales of omeprazole were 5.9 billion. By 2001, sales were 5.7 billion, and the worldwide market for ulcer drugs exceeded 14 billion. There are now five benzimidazole compounds available from a number of companies. Omeprazole went off patent in 2001 and is now available as generic drug. 

Aluminum compounds are also used extensively in the manufacture of cosmetics (e.g., aluminum hexahydrate in deodorants) and in medical treatments (e.g., aluminum hydroxide in antacids to control gastric hyperacidity or aluminum oxide in dental ceramic implants) (Brusewitz 1984 NRC 1982). In addition, antacids and buffered aspirin contain 4-562 mg/kg (ppm) of aluminum (Schenck et al. 1989 Shore and Wyatt 1983). Lione (1985a) reported aluminum content/dose (single tablet or 5 mL liquid) for antacids, internal analgesics (buffered aspirins), antidiarrheals, and anti-ulcerative drugs (Table 5-7). 

Galewitz P. Ulcer drug is world s top seller. Associated Press. February 16, 1999. 

Heterocyclic chemistry is a large and important branch of organic chemistry. Heterocycles occur in nature, for instance in nucleic acids (see Chapter 10) and indole alkaloids (see Chapter 7). Synthetic heterocycles have widespread uses as herbicides (e.g. 1.1), fungicides (e.g. 1.2), insecticides (e.g. 1.3), dyes (e.g. 1.4), organic conductors (e.g. 1.5), and, of course, pharmaceutical products such as the anti-ulcer drug 1.6. 

This anti-ulcer drug has some obvious similarities to Tagamet, and some differences too. Here are the two structures side-by-side. 

The first multi-million pound drug (1970s) was Tagamet, the anti-ulcer drug, and among the most topical of current drugs is Viagra (1997) for treatment of male impotence. 

Anon (2005) H, pylori eradication in NSAID-associated ulcers. Drugs and Therapeutics Bulletin 43 37-40. 

Thiazolidines have been reported to be a core scaffold for antiulcer compounds. La Mattina et al. have evaluated a series of 128 compounds belonging to 4-substituted-2-guanidino thiazoles (Fig. 12) against gastric hydrogen-potassium stimulated adenosine triphosphatase (H K -ATPase), a therapeutic target of anti-ulcer drugs [116]. 

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