Ulcer drugs cimetidine

For example, researchers from Smith Kline, French Laboratories has described (Ref. 36) a new facile synthesis of the anti-ulcer drug Cimetidine ( Tagamet ) depicted on scheme 39 ... 

The development of the anti-peptic ulcer drug cimetidine gives a fascinating insight into the important role of pfCa in chemistry. Peptic ulcers are a localized erosion of the mucous membrane, resulting from overproduction of gastric acid in the stomach. One of the compoimds that controls the produc-... 

In more modern times, the first successful anti-ulcer drug, cimetidine 3, with its ability to block histamine synthesis in the stomach, is an imidazole and the classical anti-depressant valium 4 has a seven-membered ring heterocycle that is not (quite) aromatic. 

Certain drugs can reduce the ability of the liver to clear benzodiazepines from the body. These include ulcer drugs, such as cimetidine (Tagamet), birth control pills, propranolol (used to treat hypertension, heart disorders, and migraines), and disulfuram (Antabuse), which is used for the treatment of alcoholism. 

The Pioneer Drug, Cimetidine A Breakthrough for Treating Peptic Ulcer Disease... 

The discovery and development of cimetidine and ranitidine provided a revolution in the medical treatment and management of peptic ulcer disease. Subsequently, many pharmaceutical companies became involved in research programs to discover additional compounds as H2-receptor histamine antagonists. As a result, a very wide range of chemical structures now exists for this class of drug (for a review, see Cooper et al. [19]). Many of these compounds have been investigated in human studies, but only the above-mentioned five drugs - cimetidine, ranitidine, nizatidine, famotidine, and roxatidine - are marketed as medicines. 

Tn Chapter 43 we mentioned the role of histamine in promoting acid secretion in the stomach, and its role in causing gastric ulcers. The drug cimetidine was designed to counteract the effect of histamine. Histamine is produced in the body by decarboxylation of histidine using the mechanism you have just seen. 

Garcia Rodriguez LA, Wallander MA, Strieker BH. The risk of acute liver injury associated with cimetidine and other acid-suppressing anti-ulcer drugs. Br J Qin Pharmacol 1997 43(2) 183-8. 

Moller H, Nissen A, Mosbech J. Use of cimetidine and other peptic ulcer drugs in Denmark 1977-1990 with analysis of the risk of gastric cancer among cimetidine users. Gut 1992 33(9) 1166-9. 

Diuretics, by increasing kidney output, deplete calcium, magnesium, potassium, and zinc. This, in turn, depletes energy and lowers immune function. Over-the-counter antacids, as well as the peptic ulcer medication cimetidine, reduce iron and calcium assimilation, vitamin Bj , and intrinsic factor (without which Bi2 can t be absorbed). Drugs prescribed for heart disease reduce libido, and some of them render men impotent. 

Sample Urine sample (1 mL), add 25 pL of 14.8 M NH4OH and mix. Solutes Cimetidine, an ulcer drug. 

A series of anti-ulcer drugs such as cimetidine and ranitidine were the most successful drugs of all time when they first appeared. They work by inhibiting histamine action in the stomach. We shall look at a more modern version, a drug from what was then SmithKline Beecham, another H2 receptor histamine antagonist24 202. It is particularly appropriate for this chapter as it contains three heterocyclic rings with two heteroatoms each an imidazole, a pyrimidone, and a thiazole and it allows us to revise material from other chapters as well as this. 

Several drugs act on exocrine and endocrine glands. Histamine brings about secretion of hydrochloric acid into the stomach, and the great success of the drug cimetidine (9.58) is that it relieves peptic ulcer by preventing this. 

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