Acetaldehyde chloro

Chloroacetoaldehyde dimethyl acetal Acetaldehyde, chloro-, dimethyl acetal (8) Ethane, 2-chloro-1,1-dimethoxy- (9) (97-97-2)... 

Thus the condensation of dichloroether or chloroacetone fails to give the parent compound, 2-hydroxythiazole (158a), Rj = R2 = R3 = H (221). However, 2-hydroxythiazole can be obtained in 12% yield from chloro-acetaldehyde (386). The condensation of ammonium thiocarbamate with cf-chloroketones gives the corresponding 2-hydroxy derivatives in 25 to 70% yields (76, 221, 304, 412) (Table 11-24). These compounds condensed with ClP(S)(OEt)2 give the corresponding 2-thiazolyl-thiophosphates (791). 

An aryloxypyrimi done has been described as an anti ulcer agent this activity is of note since the agent does not bear any structural relation to better known anti ulcer drugs. Displacement of halogen on the acetal of chloro-acetaldehyde by alkoxide from m-cresol gives the intermediate This affords enaminoaldehyde when subjected... 

A) The preparation of [H-chloroethoxyjchloromethyl]phosphonic acid Acetaldehyde (1.1 mol) and hydroxymethylphosphonlc acid (1 mol) in 500 ml of benzene are saturated with hydrogen chloride gas at 10°C to 15°C. The mixture is aged at 25°C for 24 hr, the solvent distilled out in vacuo and the residue flushed three times with benzene to remove all traces of hydrogen chloride. The residue is taken up in benzene (500 ml), treated with tert-butyl hypochlorite (0.8 mol) and azobisisobutyronitrile (0.8 mm) at 40°C until titration shows the absence of hypochlorite and the solution is then evaporated to yield [(1-chloro-ethoxy)chloromethyll phosphonic acid in the form of an oil. 

Initial work was carried out with 3,9-bis(methylene-2,4,8,10-tetraoxaspiro[5,5] undecane) where R = H (11). However, this monomer contains two electron donor alkoxy groups on one double bond which is thus highly susceptible to a cationic polymerization. For this reason, the monomer is extremely difficult to handle and cannot be analyzed by gas chromatography since it does not survive passage through the column. It is prepared by the dehydrohalogen-ation reaction of the reaction product of pentaerythritol and chloro-acetaldehyde,... 

The results of the olefin oxidation catalyzed by 19, 57, and 59-62 are summarized in Tables VI-VIII. Table VI shows that linear terminal olefins are selectively oxidized to 2-ketones, whereas cyclic olefins (cyclohexene and norbomene) are selectively oxidized to epoxides. Cyclopentene shows exceptional behavior, it is oxidized exclusively to cyclopentanone without any production of epoxypentane. This exception would be brought about by the more restrained and planar pen-tene ring, compared with other larger cyclic nonplanar olefins in Table VI, but the exact reason is not yet known. Linear inner olefin, 2-octene, is oxidized to both 2- and 3-octanones. 2-Methyl-2-butene is oxidized to 3-methyl-2-butanone, while ethyl vinyl ether is oxidized to acetaldehyde and ethyl alcohol. These products were identified by NMR, but could not be quantitatively determined because of the existence of overlapping small peaks in the GC chart. The last reaction corresponds to oxidative hydrolysis of ethyl vinyl ether. Those olefins having bulky (a-methylstyrene, j8-methylstyrene, and allylbenzene) or electon-withdrawing substituents (1-bromo-l-propene, 1-chloro-l-pro-pene, fumalonitrile, acrylonitrile, and methylacrylate) are not oxidized. 

Acetamido-4-amino-6-chloro-s-triazine, see Atrazine Acetanilide, see Aniline, Chlorobenzene, Vinclozolin Acetic acid, see Acenaphthene, Acetaldehyde, Acetic anhydride. Acetone, Acetonitrile, Acrolein, Acrylonitrile, Aldicarb. Amyl acetate, sec-Amyl acetate, Bis(2-ethylhexyl) phthalate. Butyl acetate, sec-Butyl acetate, ferf-Butyl acetate, 2-Chlorophenol, Diazinon. 2,4-Dimethylphenol, 2,4-Dinitrophenol, 2,4-Dinitrotoluene, 1,4-Dioxane, 1,2-Diphenylhydrazine, Esfenvalerate. Ethyl acetate, Flucvthrinate. Formic acid, sec-Hexyl acetate. Isopropyl acetate, Isoamyl acetate. Isobutyl acetate, Methanol. Methyl acetate. 2-Methvl-2-butene. Methyl ferf-butvl ether. Methyl cellosolve acetate. 2-Methvlphenol. Methomvl. 4-Nitrophenol, Pentachlorophenol, Phenol. Propyl acetate. 1,1,1-Trichloroethane, Vinyl acetate. Vinyl chloride Acetoacetic acid, see Mevinphos Acetone, see Acrolein. Acrylonitrile. Atrazine. Butane. 

The one-pot synthesis of 4-azaindole is also initiated by photoirradiation 3-amino-2-chloro-pyridine and acetaldehyde are the starting materials (Fontan et al. 1981 Scheme 7.37). 

The key step in the synthetic routes described in Section 6.4.1 is the DERA-cata-lyzed tandem aldol reaction of chloroacetaldehyde (CIAA) with two equivalents of acetaldehyde (AA) to lactol 1 proceeding via a monoaldol intermediate (S)-4-chloro-3-hydroxybutanal 7 and the open form of lactol 1 6-chloro-(3R,5S)-dihydroxyhex-anal (8) (Scheme 6.4). 

Scheme 6.4 DERA-catalyzed stereoselective tandem aldol reaction, using chloroacetaldehyde and 2 equivalents of acetaldehyde, yielding (3R,5S)-6-chloro-2,4,6-trideoxyhexapyranoside (1).

The amount of DERA that has to be added for the production of (3R,5S)-6-chloro-2,4,6-trideoxyhexapyranoside (1) is significant, which can clearly be attributed to the rapid deactivation of the enzyme during reaction, arising from substrates and the reaction products. The Km value of DERA for CLAA at saturating acetaldehyde... 

Subsequently, a simpler procedure was devised for the preparation of (45) and the methyl derivative, chloro(acetylacetonato)-(ir-propen-2-ol)platinum(II) (48), which involved simply treating (43) with acetaldehyde or acetone in the presence of aqueous potassium hydroxide (45, 46). The respective a complexes are obtained as the potassium salts (46) and (47), most probably via attack by the a carbanion of the acetaldehyde or acetone on the platinum. 

Eq. 5.2 shows the preparation of 3-chloro-4-acetyl-6-methylpyridazine (4) by the treatment of 3-chloro-6-methylpyridazine (3) and acetaldehyde in an aq. acidic solution with the Fenton system. HO formed from the Fenton system, abstracts a formyl hydrogen atom from acetaldehyde to form a nucleophilic acetyl radical. This radical reacts at the electrophilic 4-position of 3-chloro-6-methylpyridazinium salt formed in acidic solution,... 

Condensations of erythritol with benzaldehyde,78,78 o-, wi-andp-chloro-benzaldehyde,18 p-methylbenzaldehyde,18 p-methoxybenzaldehyde,18 o-, m- and p-nitrobenzaldehyde,18,87 3-nitro-4-chlorobenzaldehyde,18 acetaldehyde,74 chloroacetaldehyde,74 acetone,1718 formaldehyde,78 and val-eraldehyde76 have been reported, but in no case has the structure of the product been determined. The physical constants of these acetals and ketals are recorded in Table VII. The photo-sensitivity of o-nitrobenzyl-idene-erythritols has been discussed on page 149. 

Chloral chloretoxyfos, chloralose, DDT, dichlorvos, dicofol, methoxychlor, naled, plifenate, trichlamide, trichlorfon, triforine Chlordane heptachlor Chlordene chlordane Chlorine cyanide see cyanogen chloride Chloro acetaldehyde nipyraclofen, oxabetrinil Chloro acetone pymetrozine Chloro acetonitrile thicyofen... 

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