Nonsteroidal anti-inflammatory drug-induced ulcers

Agrawal NM, Roth S, Graham DY, White RH, Germain B, Brown JA, Stromatt SC. Misoprostol compared with sucralfate in the prevention of nonsteroidal anti-inflammatory drug-induced gastric ulcer. A randomized, controlled trial. Ann Intern Med 1991 115(3) 195-200. 

Recognize differences between ulcers induced by Helicobacter pylori (HP) and nonsteroidal anti-inflammatory drugs (NSAIDs) in terms of risk factors, pathogenesis, signs and symptoms, clinical course, and prognosis. 

H2 Antagonists and the Treatment of Peptic Ulcers. Treatment of peptic ulcers is a complicated and multilevel therapy in which Hj antagonists are very successful and widely used (and abused). Peptic ulcers may affect either the stomach (gastric ulcers, less common overall but more common in people with iatrogenic [i.e., physician-induced] ulcers from the use of nonsteroidal anti-inflammatory drugs [NSAIDs]) or the duodenum (duodenal ulcers). The lining of the stomach or duodenum is attacked by the digestive juices to such an extent that the protective mucous layer on the surface has... 

Nonsteroidal anti-inflammatory drugs are probably more likely to induce gastric ulceration in older than... 

Wallace JL, Keenan CM, Granger DN. Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process. Am J Physiol 1990 259(3 Pt 1) G462-7. 

GI Injury and Ulcer Models Acute or chronic GI injury models are induced by various compounds or agents in rodents. Intragas trie administrations of concentrated ethanol (50-100%), sodium hydroxide (NaOH), acetic acid, and hydrochloric acid (HCl) have been shown to induce mucosal injury in fasted rats. Of these models, ethanol and HCL models are relevant to humans, mimicking alcohol consumption and overproduction of HCL in the stomach. GI ulcer models include administration of nonsteroidal anti-inflammatory drugs (NSAIDs) such as... 

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