Types of Regulatory T Cells

Types of Regulatory T Cells Naturally Occurring Treg Cells... 

Thomas D, Zaccone P, Cooke A. 2005. The role of regulatory T cell defects in Type I diabetes and the potential of these cells for therapy. Rev Diabet Stud. 2 9-18. 

Hoffinann KF, Cheever AW, Wynn TA 2000 IL-10 and the dangers of immune polarization excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathol-ogy in murine schistosomiasis. J Immunol 164 6406—6416 Hori S, Nomura T, Sakaguchi S 2003 Control of regulatory T cell development by the transcription factor FOXP3. Science 299 1057—1061... 

Inhibition of human allergic T-helper type 2 immune responses by induced regulatory T cells requires the combination of interleukin- 10-treated dendritic cells and transforming growth factor-p for their induction. Clin Exp Allergy 2006 36 1546-1555. 

Control of Delayed-Type Hypersensitivity by Ocular-Induced CD8+ Regulatory T Cells... 

Cone RE, Li X, Sharafieh R, O Rourke J, Vella AT The suppression of delayed-type hypersensitivity by CD8+ regulatory T cells requires interferon-y. Immunology 2007 120 112-119. 

The nonobese diabetic mouse (NOD), as well as the biobreeding (BB) rats are the two rodent models whose diabetes-related immunopathology is considered to be quite similar to that in humans. Studies in these animal models have revealed that autoreactive T cells that mediate islet 8 cell destruction belong to the Thl subset of T cells (produce IL-2 and IFN-7), whereas regulatory T cells are of the Th2 type (produce IL-4 and IL-10). Because Thl and Th2 cells are mutually inhibitory, there have been many trials using IL-4 and/or IL-10 for the prevention of autoimmune disease, like autoimmune diabetes, rheumatoid arthritis (Evans et al., 1996 Boyle et al., 1999), and inflammatory bowel disease (Rogy et al., 2000). 

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