Naturally Occurring Treg Cells

Types of Regulatory T Cells Naturally Occurring Treg Cells 

The Treg cells have been classified on the basis of their site of origin or mechanism of action (Table 9.1). The site of origin is for the naturally occurring Treg cells in thymus, and the main mechanism of action is via cell-cell interaction. 

Peripheral Treg cells CD4+,CD25+r FoxP3 /FoxP3+ 

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Table 9.2 Phenotypic Markers of Naturally Occurring Treg Cells...

It had been widely accepted that autoimmune T cells in the periphery are normally kept in a state of tolerance by the suppressive activity of naturally occurring regulatory CD4 CD25 T cells (Treg cells) (Thornton and Shevach, 2000), and that elimination or depletion of Treg cells might therefore cause development of an autoimmune disease in susceptible animals (McHugh etal., 2002). 

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