Two preparation

An important purpose of a designed experiment is to obtain information about interactions among the primary variables. This is accompbshed by varying factors simultaneously rather than one at a time. Thus in Figure 2, each of the two preparations would be mn at both low and high temperatures using, for example, a full factorial experiment. 

Two checks of the accuracy of the determinations of the lattice constants were made. Filings of samples 2 and 3 were placed in capillary tubes of two different diameters, and photographs were made and interpreted. For each sample the same lattice constant was obtained from the two photographs. For samples 11 and 14 filings were prepared from two different portions of the 25 g. sample, and powder photographs were prepared. In the case of specimen 11 the lattice constant determined from the two preparations was the same, whereas for specimen 14 values differing by 0-0055 A were obtained. We believe that the latter variation is due to a small difference in composition, perhaps 0-5 %, in the two samples the lattice constant is very sensitive to composition in this region. 

Bioavailahility studies are used to compare different formulations of the drug product, or different batches of the same formulation and, as discussed in Chapter 8, generic copies of a reference drug. Their comparative value is based on the premise that, if similar amounts of identical active substance are delivered to the site of action at similar rates, then a similar biological response can be expected, which leads to the conclusion that the two preparations are bioequivalent. 

Two preparations of diesters of phosphonous acid have been reported, - One of these, which claims to be the first preparation of these derivatives, involves the reaction of ammonium hypophosphite with triaikylsilylamines to give bis(trialkylsilyl) esters (127) in excellent yield. These compounds are extremely reactive, e.g. they are spontaneously inflammable in air. Dialkyl phosphonites (128) have also been prepared by the reduction of... 

Safety considerations are paramount in any boron hydride synthesis. The energy yield from the oxidations of boron hydrides is too high for any cavalier treatment of boron hydrides. Exclusion of air is the critical consideration in diborane reactions. Decaborane(14) is less reactive, generally, in a kinetic sense, but the thermodynamic potential is comparable. In addition, all volatile boron hydrides are toxic. The procedures described in the latter two preparations are within our experience non-hazardous. These procedures should be followed in every detail improvisation is not recommended. 

To continue this investigation we studied the influence and mechanism of action of two preparations of pristine fullerene C60, namely, the C60/PVP complex and fullerene on the surface (FoS) on the cells in the culture. 

Enol esters are distinct from other esters not because of a particular stability or lability toward hydrolases, but due to their hydrolysis releasing a ghost alcohol (an enol), which may immediately tautomerize to the corresponding aldehyde or ketone. A well-studied example is that of vinyl acetate (CH3-C0-0-CH=CH2), a xenobiotic of great industrial importance that, upon hydrolysis, liberates acetic acid (CH3-CO-OH) and acetaldehyde (CH3-CHO), the stable tautomer of vinyl alcohol [25], The results of two studies are compiled in Table 7.1, and demonstrate that vinyl acetate is a very good substrate of carboxylesterase (EC 3.1.1.1) but not of acetylcholinesterase (EC 3.1.1.7) or cholinesterase (EC 3.1.1.8). The presence of carboxylesterase in rat plasma but not in human plasma explains the difference between these two preparations, although the different experimental conditions in the two studies make further interpretation difficult. 

The similarities in the structure and 3neld of the acids obtained by this degradation from natural spruce lignin and a biosynthetic "spruce lignin copolymer (mixed DHP) made in vitro from a mixture of the three -coumaryl alcohols established the general identity of the two preparations 46, 47). 

Shao et al. [25] prepared Mg Ni from magnesium and nickel nanoparticles produced by hydrogen plasma-metal reaction. Two preparation methods were developed to obtain the compound. One is heating the nanoparticles under 0.10 MPa argon pressure at 430°C and the other is under 3.00 MPa hydrogen pressure at 280°C. No hydrogen storage properties of this material were assessed. 

III, D). This combination has been used to prepare Np metal which is 99.9 at % pure. Analyses of two preparations are given in Table VII 20). A... 

Two preparations of Cm metal by the metallothermic reduction of CmFj with Ba metal (Section II,A) have been reported (29,119). The... 

The applicants are generally advised to have a pre-submission meeting with the EMEA Secretariat. On receipt of a valid application, COMP appoints an EMEA coordinator and a COMP member as a coordinator (Day 0). These two prepare a joint report for discussion at the following... 

Captopril and enalapril are the standard examples of ACE-inhibitors, which have been used on a large scale for almost two decades. The differences between the two preparations are predominantly based on pharmacokinetic parameters. Enalapril is a prodrug, which is converted into its active compound enalaprilate after oral ingestion captopril is active as such. Enalapril can be given once daily, whereas... 

Checkers indicate that product can be easily lost if care is not exercised in removing the solvent. Best results (75 and 80% yields for two preparations) were obtained by removing Et20 at 0°C. 

The azines represent another class of organic compounds which, in principle, should be reducible to azo compounds. The method is attractive since, with the availability of anhydrous hydrazine, azines are readily prepared from a wide variety of ketones and aldehydes. Evidently, introduction of 1 gram-molecule of hydrogen into an azine molecule has only recently been accomplished (see Section 6, Procedure 8) [73], Two preparations involving the 1,4-addition of chlorine to an azine system have been carried out and are illustrated here. 

The following two preparations illustrate the addition of nitrosyl halides to norbornene. In the first one, nitrosyl chloride itself is used in the second, nitrosyl bromide is generated in situ. 

Table II shows the experimental data as well as the maximum overall reaction rates of the monomers studied. All figures are average values of at least two preparations—i.e., four dilatometric measurements. The last column gives the reaction rate relative to that of a comparable styrene emulsion under the same conditions of temperature and dose rate whose reaction rate was accepted as unity.

A hitherto unpublished preparation of diazomethane is given on p. 16. The starting material is the commercially available bis-(N-methyl-N-nitroso)-terephthalamide, and the procedure conveniently affords 0.76 to 0.86 mole of ethereal diazomethane. Ozonization in polar solvents is illustrated by two preparations (pp. 41 and 46). Many other unusual and interesting preparations are included, such as ruthenocene (p. 96), N,N-di thyltri-chlorovinylamine (p. 21), phenyl tert-butyl ether (p. 91), and tetramethylammonium 1,1,2,3,3-pentacyanopropenide (p. 99). 

Current interest in cyclopropanes is reflected by two preparations Norcarane from cyclohexene, methylene iodide, and zinc-copper couple (p. 72) illustrates a new way of adding a methylene... 

Au3CoRu3(CO)12(PPh3)3. The first two preparations are minor modifications of those reported in the literature.6,8... 

Colloids (casein micelles) of two different particle sizes are isolated from skim milk by centrifugation under different conditions. The sedimentation and diffusion coefficients of the two preparations are as follows ... 

Phenylselenoacetaldehyde, OHCCH2ScC6H5 (I), 9, 365 366. Two preparations have been reported (equations I1 and II2). 

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