Tumors, resveratrol suppression

Moon SO, Kim W, Sung MJ, Lee S, Kang KP, Kim DH, Lee SY, So JN, Park SK. 2006. Resveratrol suppresses tumor necrosis factor-alpha-induced fractalkine expression in endothelial cells. Mol Pharmacol 70 112-119. 

Resveratrol (3,5,4-trihydroxystilbene), which occurs naturally in grapes and other foods, has chemopreventive effects in different systems, based on its striking inhibition of diverse cellular events associated with tumor initiation, promotion, and progression (27). We found that resveratrol suppressed tumor-... 

Condensation of coumaric acid with malonic acid yields the basic chalcone and stilbane skeletons (see Fig. 3.6). Stilbenes are found in most vascular plants, where they exhibit fungicidal and to a lesser extent antibiotic properties. They function as both constitutive and inducible defense substances. Some stilbenes inhibit fungal spore germination and hyphal growth, whereas others are toxic to insects and parasitic nematodes (round-worms). They also possess antifeeding and nematicide properties in mammals. For example, resveratrol (a stilbene in red wine) suppresses tumor formation in mammals. 

Resveratrol has been reported to have chemo-preventive activity in a mouse model of carcinogenesis, but there is a concentration-dependent effect, and at the concentrations used in vitro the effect is predominantly antiproliferative. It has also been reported to have mitochondrial-dependent apoptotic activity against a variety of cell lines. Resveratrol has been reported to inhibit the constitutive COX-1, but it is not clear whether it inhibits the inducible COX-2. These cyclo-oxygenases stimulate tumor growth by acting on cell proliferation, angiogenesis, and immuno-suppression.f °° ... 

Several reports indicate that p53 is required in resveratrol-induced apoptosis in different cell systems. It has been shown to suppress tumor promoter-induced cell transformation and to stimulate p53-dependent transcriptional activation [148]. Moreover, resveratrol-induced apoptosis occurred only in fibroblasts expressing wild-type and not in p53-deficient (p5j ) cells [148]. In cultured human... 

Suppressing mechanism This mechanism includes elimination of tumor cells, including growth inhibition by induction of cell-cycle arrest or apoptosis. Apigenin has been shown to induce G2/M arrest in SW480 and Caco-2 human colon carcinoma cells [40], Resveratrol and quercetin are reported to induce the expression of caspase-3 promoting apoptosis, arresting cells in G1 phase of the cell cycle, and decrease tiunor cell invasion [41]. 

Brakenhiehn E, Cao R, Cao Y. Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes. FASEB J 2001 15 1798-1800. 

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